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Dtsch Med Wochenschr 2010; 135(6): 256-259
DOI: 10.1055/s-0030-1247864
DOI: 10.1055/s-0030-1247864
Arzneimittel & Pharmakotherapie | Review
article
Angiologie
© Georg Thieme Verlag KG Stuttgart · New York
Dabigatran: eine neue Option zur Therapie und Prophylaxe thrombembolischer Erkrankungen?
Dabigatran: a new therapeutic option for therapy and prophylaxis of thromboembolic diseases?Further Information
Publication History
eingereicht: 27.8.2009
akzeptiert: 26.11.2009
Publication Date:
26 January 2010 (online)
![](https://www.thieme-connect.de/media/dmw/201006/lookinside/thumbnails/10.1055-s-0030-1247864-1.jpg)
Schlüsselwörter
Dabigatran - Thrombose - direkter Thrombininhibitor
Keywords
dabigatran - thrombosis - direct thrombin inhibitor
Literatur
- 1 Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos. 2008; 36 386-399
- 2 Cohen A T, Tapson V F, Bergmann J F, Goldhaber S Z, Kakkar A K, Deslandes B, Huang W, Zayaruzny M, Emery L, Anderson Jr F A. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet. 2008; 371 387-394
- 3 Connolly S J, Ezekowitz M D, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly P A, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis B S, Darius H, Diener H C, Joyner C D, Wallentin L. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009; 361 1139-1151
- 4 Di Nisio M, Middeldorp S, Buller H R. Direct thrombin inhibitors. N Engl J Med. 2005; 353 1028-1040
- 5 Eriksson B I, Dahl O E, Rosencher N, Kurth A A, van Dijk C N, Frostick S P, Kalebo P, Christiansen A V, Hantel S, Hettiarachchi R, Schnee J, Buller H R. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost. 2007; 5 2178-2185
- 6 Eriksson B I, Dahl O E, Rosencher N, Kurth A A, van Dijk C N, Frostick S P, Prins M H, Hettiarachchi R, Hantel S, Schnee J, Buller H R. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet. 2007; 370 949-956
- 7 Hirsh J, Dalen J, Anderson D R, Poller L, Bussey H, Ansell J, Deykin D. Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest. 2001; 119 8S-21S
- 8 Hirsh J, Dalen J E, Deykin D, Poller L, Bussey H. Oral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest. 1995; 108 231S-246S
- 9 Kubitza D, Haas S. Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases. Expert Opin Investig Drugs. 2006; 15 843-855
- 10 Liesenfeld K H, Schafer H G, Troconiz I F, Tillmann C, Eriksson B I, Stangier J. Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis. Br J Clin Pharmacol. 2006; 62 527-537
- 11 Stangier J, Eriksson B I, Dahl O E, Ahnfelt L, Nehmiz G, Stahle H, Rathgen K, Svard R. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol. 2005; 45 555-563
- 12 Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol. 2007; 64 292-303
Dr. Natig Gassanov
Herzzentrum Köln, Klinik III für
Innere Medizin
Kerpener Str. 62
50924 Köln
Phone: 0221/47832544
Email: Natig.Gassanov@uk-koeln.de