Planta Med 2000; 66(3): 279-281
DOI: 10.1055/s-0029-1243137
Letter

© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity of Coumarins from Decatropis bicolor on TPA Ear Mice Model

Aída N. García-Argáez1 , Teresa O. Ramírez Apan2 , Hortensia Parra Delgado2 , Guillermo Velázquez2 , Mariano Martínez-Vázquez2 ,*
  • 1Laboratorio de Química, Facultad de Ciencias, Universidad Nacional Autónoma de México, México
  • 2Instituto de Química, Universidad Nacional Autónoma de México, México
Further Information

Publication History

Received: June 16, 1999

Accepted: July 11, 1999

Publication Date:
25 November 2009 (online)

Abstract

From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1–6 were examined against the ear edema in mice produced by TPA. The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.

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Dr. Mariano Martínez-Vázquez

Instituto de Química

Universidad Nacional Autónoma de México

Circuito Exterior, Ciudad Universitaria

Coyoacán 04510

México, D. F.

México

Email: marvaz@servidor.unam.mx

Fax: +525-6-16-22-03