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Planta Med 2000; 66(1): 91-93
DOI: 10.1055/s-0029-1243121
Letter

© Georg Thieme Verlag Stuttgart · New York

Interaction of Flavones from the Roots of Scutellaria baicalensis with the Benzodiazepine Site

Kwok Min Hui1 , Xi Hong Wang1 , 2 , Hong Xue1 ,*
  • 1Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
  • 2National Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, Beijing, P. R. China
Further Information

Publication History

Received: April 21, 1999

Accepted: June 27, 1999

Publication Date:
24 November 2009 (online)

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Abstract

A radioreceptor binding assay was used to guide the isolation of four chemical constituents in the organic solvent extracts of Scutellaria baicalensis Georgi capable of binding to the benzodiazepine site (BZD-S) of the GABAA receptor: wogonin (Ki = 2.03 ± 0.24µM), baicalin (Ki = 77.10 ± 4.79µM), baicalein (Ki = 5.69 ± 0.95µM), and scutellarein (Ki = 12.00 ± 1.27µM). All four compounds contain the flavonoid phenylbenzopyrone nucleus. Based on BZD-S binding, the order of affinity among these four compounds was wogonin > baicalein > scutellarein > baicalin.

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Dr. Hong Xue

Department of Biochemistry

Hong Kong University of Science and Technology

Clear Water Bay

Kowloon

Hong Kong

Email: hxue@ust.hk

Phone: +852-2358-8707

Fax: +852-2358-1552