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Synfacts 2010(3): 0281-0281
DOI: 10.1055/s-0029-1219426
DOI: 10.1055/s-0029-1219426
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Synthesis of Quinazolines From 2-Bromobenzonitriles
X. Yang, H. Liu, H. Fu*, R. Qiao*, Y. Jiang, Y. Zhao
Tsinghua University, Beijing, Beijing University of Chemical Technology and Tsinghua University, Shenzhen, P. R. of China
Further Information
Publication History
Publication Date:
18 February 2010 (online)
Significance
Reported is the formation of quinazolines using sequential Ullmann coupling and nucleophilic addition reactions. Although the mechanism is only briefly discussed in this publication, the postulation of an Ullmann-type cross-coupling reaction, followed by nucleophilic attack of the free amine on the nitrile is entirely reasonable.