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Synthesis 2009(16): 2725-2728  
DOI: 10.1055/s-0029-1216878
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Assisted Silver(I)-Mediated Selective O-Alkylation of Aromatic Imidate Systems

Brajendra K. Singha,b, Claudia Cavalluzzoa, Marc De Maeyerc, Zeger Debyserd, Virinder S. Parmarb, Erik Van der Eycken*a
a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium
Fax: +3216327990; e-Mail: erik.vandereycken@chem.kuleuven.be;
b Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India
c Laboratory for Biomolecular Modelling, Katholieke Universiteit Leuven, Celestijnenlaan 200G, 3001 Leuven, Belgium
d Molecular Medicine, Katholieke Universiteit Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
Further Information

Publication History

Received 8 April 2009
Publication Date:
26 June 2009 (online)

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Abstract

A novel microwave-assisted protocol has been developed for the selective O-alkylation of aromatic imidate systems with various halides under microwave irradiation using silver carbonate as the base. Products were obtained in short reaction time and in excellent yields.

Key words

O-alkylation - silver carbonate - microwave - 2-pyridones - 2-(1H)-pyrazinones

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