Synfacts 2009(6): 0643-0643  
DOI: 10.1055/s-0029-1216781
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective, Copper-Catalyzed Three-Component Reaction

Contributor(s): Mark Lautens, Jacki Kitching
Z. Shao*, X. Pu, X. Li, B. Fan, A. S. C. Chan*
The Hong Kong Polytechnic University and Yunnan University, Kunming, P. R. of China
Further Information

Publication History

Publication Date:
25 May 2009 (online)

Significance

As an extension on previous research concerning the asymmetric synthesis of ­aliphatic alkynyl α-amino acid derivatives (Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 11196), the ­authors now describe the copper-catalyzed three-component reaction between ethyl glyoxylate, 4-anisidine and alkynes. The β,γ-alkynyl α-amino acid derivatives are obtained in good yield and enantioselectivity.