Endoscopy 2009; 41(10): 855-860
DOI: 10.1055/s-0029-1215089
DDW highlights

© Georg Thieme Verlag KG Stuttgart · New York

Reflux disease and Barrett’s esophagus

A.  M.  Panossian1 , H.  C.  Wolfsen1
  • 1Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, Florida, USA
Further Information

Publication History

Publication Date:
11 September 2009 (online)

Introduction

Digestive Disease Week (DDW) 2009 in Chicago featured several important presentations regarding the improved diagnosis of, detection of dysplasia in, and endoscopic therapy for Barrett’s disease. Among the 322 abstracts concerning gastroesophageal reflux disease (GERD) and Barrett’s esophagus (BE), there were several describing outstanding multicenter, controlled, randomized trials that were presented at plenary sessions.

References

  • 1 Wolfsen H C, Crook J E, Krishna M. et al . Prospective, controlled tandem endoscopy study of narrow band imaging for dysplasia detection in Barrett’s esophagus.  Gastroenterology. 2008;  135 24-31
  • 2 Sharma P, Bansal A, Hawes R H. et al . Detection of metaplasia (IM) and neoplasia in patients with Barrett’s esophagus (BE) using high-definition white light endoscopy (HD-WLE) versus narrow band imaging (NBI): a prospective, multi-center, randomized, crossover trial.  Gastrointest Endosc. 2009;  69 AB135
  • 3 Meining A, Vieth M, Rosch T. et al . Probe-based confocal endomicroscopy is equivalent to standard four-quadrant-stepwise biopsy technique for diagnosis of neoplasia arising from Barrett’s esophagus.  Gastroenterology. 2009;  136 A-130
  • 4 Wallace M B, Abrams J A, Bajbouj M. et al . Accuracy and inter-observer agreement of experts for probe-based confocal laser endomicroscopy detection of dysplasia in barrett’s esophagus.  Gastrointest Endosc. 2009;  69 AB351
  • 5 Wax A, Zhu Y, Terry N G. et al . Label-free nuclear morphology measurements of dysplasia in the EGDA rat model using angle-resolved low coherence interferometry.  Gastroenterology. 2009;  136 A-122
  • 6 DeVault K R, Leemis J D, Coe S G. et al . T1889 Short segment Barrett’s esophagus: variability of approach and diagnostic yield.  Gastroenterology. 2009;  136 A-594
  • 7 Shaheen N J, Sharma P, Overholt B F. et al . Radiofrequency ablation in Barrett’s esophagus with dysplasia.  N Engl J Med. 2009;  360 2277-2288
  • 8 Van Vilsteren F G, Pouw R E, Seewald S. et al . A multi-centered randomized trial comparing stepwise radical endoscopic resection versus radiofrequency ablation for Barrett esophagus containing high-grade dysplasia and/or early cancer.  Gastrointest Endosc. 2009;  69 AB133-AB134
  • 9 Thomas T, Ayaru L, Lee E Y. et al . Extensive endomucosal resection (EMR) of Barrett’s esophagus (BE) with high-grade intraepithelial neoplasia (HGIN) or intramucosal carcinoma (IMC): efficacy, safety and factors predicting complete eradication.  Gastrointest Endosc. 2009;  69 AB340
  • 10 Canto M I, Gorospe E C, Shin E J. et al . Carbon dioxide (CO2) cryotherapy is a safe and effective treatment of Barrett’s esophagus (BE) with HGD/intramucosal carcinoma.  Gastrointest Endosc. 2009;  69 AB341
  • 11 Shaheen N J, Greenwald B D, Dumot J A. et al . Safety and efficacy of endoscopic spray cryotherapy for Barrett’s esophagus with high-grade dysplasia.  Gastrointest Endosc. 2009;  69 AB357
  • 12 Greenwald B D, Dumot J A, Abrams J A. et al . Endoscopic spray cryotherapy for esophageal cancer: safety and efficacy.  Gastrointest Endosc. 2009;  69 AB349
  • 13 Herrero L A, Pouw R E, Van Vilsteren F G. et al . What are the outcomes of endoscopic radiofrequency ablation for very long segments of Barrett esophagus containing neoplasia?.  Gastrointest Endosc. 2009;  69 AB116
  • 14 Panjehpour M, Overholt B F, Phan-Brooks M N. et al . Photodynamic therapy (PDT) for Barrett’s esophagus with dysplasia: long-term follow-up of gastroesophageal junction area is recommended.  Gastrointest Endosc. 2009;  69 AB339-AB340
  • 15 Shaheen N J, Bright S D, Madanick R D. et al . What is the efficacy of high-dose acid suppression in chronic cough? A randomized, double-blind, placebo-controlled trial.  Gastroenterology. 2009;  136 A-79
  • 16 Vaezi M F, Hagaman D D, Slaughter J C. et al . A randomized double-blind placebo-controlled study of acid suppression for isolated chronic postnasal drip.  Gastroenterology. 2009;  136 (5 Suppl 1) A-107
  • 17 Rosati R, Fumagalli U, Barbera R. et al . 456 Endoluminal fundoplication (ELF) for GERD – 12 month follow up.  Gastroenterology. 2009;  136 A-872
  • 18 Schreinemakers R, Smout A J, Schwartz M P. Four-year open-label follow-up of a randomized, placebo-controlled trial of endoscopic gastroplication (Endocinch) for the treatment of gastro-esophageal reflux disease (GERD). ASGE esophagus session.  Gastrointestinal Endosc. 2009;  69 AB342
  • 19 Almansa C, Cano S, DeVault K R. et al . S1862 Overlapping features between eosinophilic esophagitis and gastroesophageal reflux.  Gastroenterology. 2009;  136 A-280
  • 20 Wang K K, Fritcher E B, Halling K C. et al . The use of FISH in a multi-center blinded study to predict development of neoplasia in Barrett’s esophagus.  Gastroenterology. 2009;  136 A-157
  • 21 Kumaravel A, Lopez R, Brainard J. et al . Brush cytology versus endoscopic biopsy for surveillance of Barrett’s esophagus.  Gastroenterology. 2009;  136 A-157
  • 22 Wax A, Terry N G, Zhu Y. et al . T1881 Detection of dysplasia in Barrett’s esophagus with angle-resolved low coherence interferometry.  Gastroenterology. 2009;  136 A-592
  • 23 Westra W, Prasad G A, Halling K C. et al . Detection of high-grade dysplasia and esophageal adenocarcinoma using endoscopic mucosal resection in combination with fluorescence in situ hybridization.  Gastroenterology. 2009;  136 A-593
  • 24 Coco D, Goldblum J R, Hornick J L. et al . Interobserver variability in the diagnosis of crypt dysplasia in Barrett’s esophagus.  Gastroenterology. 2009;  136 A-593
  • 25 Doherty G A, Cheriyan D, Leyden J E. et al . Image recognition in the endoscopic diagnosis of Barrett’s oesophagus; a study of interobserver agreement and the impact of endoscopy experience.  Gastroenterology. 2009;  136 A-594
  • 26 Li Y, Dryden G W, Liu Q. et al . Endoscopic visualization of esophageal disease in rats after esophagoduodenal anastomosis.  Gastroenterology. 2009;  136 A-604
  • 27 Wani S B, Mathur S C, Curvers W L. et al . Inter-observer agreement among pathologists in the diagnosis of dysplasia in Barrett’s esophagus (BE): comparison between biopsy and EMR Specimens.  Gastroenterology. 2009;  136 A-732
  • 28 Longcroft-Wheaton G R, Duku M, Mead R. et al . Results from a large prospective series of acetic acid enhanced chromoendoscopy in evaluation of Barrett’s neoplasia: Is it time to change our practice?.  Gastrointest Endosc. 2009;  69 AB115
  • 29 Chaurand-Lara M, Sobrino-Cossio S R, Hernandez-Guerrero A. et al . Narrow band imaging to identify short and ultra-short segment Barrett’s esophagus in the presence of an irregular squamocolumnar junction.  Gastrointest Endosc. 2009;  69 AB354
  • 30 Wang K K, Badreddine R J, Tomizawa Y. et al . Endoscopic confocal laser microscopy with the probe system in Barretts esophagus.  Gastrointest Endosc. 2009;  69 AB349
  • 31 Wang K K, Brankley S M, Prasad G A. et al . Prospective randomized controlled trial of biomarkers to predict response to ablation therapy in Barrett’s esophagus (BE) with high grade dysplasia (HGD).  Gastroenterology. 2009;  136 A-157
  • 32 Lord R VN, Freeman A, Botelho N K. et al . Effect of Barryx halo radiofrequency ablation treatment on mRNA gene expression in Barrett’s esophagus with dysplasia.  Gastroenterology. 2009;  136 A-593
  • 33 Pouw R E, Van Vilsteren F G, Alvarez H errero. et al . Radiofrequency ablation for eradication of Barrett esophagus containing high-grade dysplasia or early cancer: a prospective series of 73 patients.  Gastrointest Endosc. 2009;  69 AB345-AB346
  • 34 Iizuku T, Kikuchi D, Hoteya S, Yahagi N. Outcomes of endoscopic submucosal dissection with flex knife for esophageal tumor in more than 300 consecutive cases.  Gastrointest Endosc. 2009;  69 AB341-AB342
  • 35 Shaheen N J, Sharma P, Overholt B F. et al . How durable is the reversion to neosquamous epithelium in subjects undergoing radiofrequency ablation for dysplastic Barrett’s esophagus? Two year follow-up of the AIM-dysplasia randomized sham-controlled trial.  Gastroenterology. 2009;  136 A-158
  • 36 Adler D C, Zhou C, Tsai T H. et al . Endoscopic three-dimensional optical coherence tomography confirms squamous epithelialization following radiofrequency ablation for Barrett’s esophagus.  Gastroenterology. 2009;  136 A-595
  • 37 Dunn J M, Mackenzie G D, Oukrif D. et al . DNA ploidy as a prognostic biomarker after ala photodynamic therapy for high grade dysplasia in Barrett’s oesophagus.  Gastroenterology. 2009;  136 A-49
  • 38 Lyday W, Corbett F S, Kuperman D A. et al . Endoscopic radiofrequency ablation of Barrett’s esophagus: safety and efficacy outcomes in 429 patients treated in a multi-center community practice registry.  Gastrointest Endosc. 2009;  69 AB114
  • 39 Pech O, Manner H, May A. et al . Endoscopic therapy in 1059 patients with high grade dysplasia and early adenocarcinoma in Barrett’s esophagus – lessons we have learned.  Gastrointest Endosc. 2009;  69 AB114-AB115
  • 40 Allison H, Banchs M A, Guelrud M. Barrett’s esophagus ablation with multipolar electrocoagulation; long term follow-up.  Gastrointest Endosc. 2009;  69 AB115
  • 41 Haringsma J, van Heel N C, Kuipers E J. Endoscopic ablation of early cancer in Barrett’s esophagus: long-term results of mucosal resection followed by photodynamic therapy.  Gastrointest Endosc. 2009;  69 AB345
  • 42 Singh M, Wani S B, Rastogi A. et al . Is proton pump inhibitor (PPI) use associated with a lower prevalence of Barrett’s esophagus (BE) in patients with chronic GERD?.  Gastroenterology. 2009;  136 A-595
  • 43 Razjouyan H, Nasseri-Moghaddam S, Ardekani B A. et al . Prevalence of columnar lined esophagus among Iranian GERD patients and the clinical correlations.  Gastroenterology. 2009;  136 A-594
  • 44 Ganz R A, Bonavina L, DeMeester T R. et al . Magnetic sphincter augmentation is safe and effective for the long-term treatment of gastroesophageal reflux disease (GERD).  Gastroenterology. 2009;  136 A-739
  • 45 Broeders J A, Rijnhart-de J ong, Draaisma W A. et al . Ten-year outcome of laparoscopic and conventional nissen fundoplication: randomized clinical trial.  Gastroenterology. 2009;  136 A-740
  • 46 Liu J J, Stenson T H, Thiesen A. Augmenting lower esophageal sphincter function and anatomy with a novel intraluminal therapy.  Gastroenterology. 2009;  136 A-740
  • 47 Boeckxstaens G E, Denison H, Ruth M. et al . Effect of AZD3355, a novel GABAB agonist, on reflux and lower esophageal sphincter function in patients with GERD with symptoms despite proton pump inhibitor treatment.  Gastroenterology. 2009;  136 A-433
  • 48 Bafutto M, Leite N V, Filho J R. Effects of combined therapy with esomeprazol and tegaserod in patients with extra-esophageal GERD not responsive to esomeprazol.  Gastroenterology. 2009;  136 A-434
  • 49 Cobell W J, Gleich G J, Thomas K. et al . Eosinophil degranulation differentiates eosinophilic esophagitis (EoE), possible EoE and GERD patients.  Gastroenterology. 2009;  136 A-279
  • 50 Poh C H, Gasiorowska A, Navarro-Rodriguez T. et al . Eosinophilic esophagitis is uncommon in male-enriched patient population with refractory heartburn.  Gastroenterology. 2009;  136 A-281
  • 51 Sá C C, Moraes-Filho J P, Eisig J N. et al . Low prevalence of eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease. a prospective study.  Gastroenterology. 2009;  136 A-282
  • 52 Kovalak M, Teman C J, Thomas K. et al . Histologic differences between eosinophilic esophagitis and reflux: something to hang your hat on.  Gastroenterology. 2009;  136 A-284
  • 53 Foltz C, Gerson L B. Effect of intravenous sedation on Bravo pH monitoring.  Gastrointest Endosc. 2009;  69 AB340-AB341

H. C. WolfsenMD 

Mayo Clinic Florida

4500 San Pablo Road
Jacksonville, Florida 32224
USA

Fax: +1-904-953-7260

Email: wolfsen.herbert@mayo.edu