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Planta Med 2010; 76(3): 284-290
DOI: 10.1055/s-0029-1186056
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

A Phenylpropanoid, a Slovenolide, Two Sulphur-Containing Germacranes and Ca2+-ATPase Inhibitors from Thapsia villosa

Juan J. Rubal1 , F. Javier Moreno-Dorado1 , Francisco M. Guerra1 , Zacarías D. Jorge1 , María del Carmen Galán2 , Ginés M. Salido2 , Søren B. Christensen3 , Helmer Søhoel3 , Guillermo M. Massanet1
  • 1Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Puerto Real, Cádiz, Spain
  • 2Department of Physiology (Cell Physiology Research Group), University of Extremadura, Cáceres, Spain
  • 3Department of Medicinal Chemistry, the Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
Further Information

Publication History

received April 22, 2009 revised June 18, 2009

accepted July 27, 2009

Publication Date:
25 August 2009 (online)

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Abstract

A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca2+]c) in human platelets in a concentration-dependent manner.

Key words

Thapsia villosa - Apiaceae - germacranes - phenylpropanoids - slovenolides - thapsigargins - transtaganolides - Ca2+‐ATPase inhibitors

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Prof. Dr. Guillermo M. Massanet

Departamento de Química Orgánica
Facultad de Ciencias
Universidad de Cádiz

Polígono Río San Pedro s/n

11510 Puerto Real

Cádiz

Spain

Phone: + 34 9 56 01 63 66

Fax: + 34 9 56 01 61 93

Email: g.martinez@uca.es

    www.thieme-connect.de/ejournals/toc/plantamedica