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Planta Med 2010; 76(2): 146-151
DOI: 10.1055/s-0029-1186031
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

New Carvotanacetone Derivatives from Sphaeranthus africanus

Consolacion Y. Ragasa1 , Po-Wei Tsai1 , Cecilia T. Galvez2 , Chien-Chang Shen3
  • 1Chemistry Department, De La Salle University and Center for Natural Sciences and Ecological Research, De La Salle University, Manila, Phillipines
  • 2Department of Biological Sciences, Central Luzon State University, Munoz Science City, Nueva Ecija, Philippines
  • 3National Research Institute of Chinese Medicine, Taipei, Taiwan
Further Information

Publication History

received March 10, 2009 revised July 8, 2009

accepted July 10, 2009

Publication Date:
10 August 2009 (online)

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Abstract

The dichloromethane extract of the air-dried leaves of Sphaeranthus africanus afforded four new carvotanacetone derivatives (1, 2, 3a, and 3b). Their structures were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1–3 exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Trichophyton mentagrophytes and Aspergillus niger.

Key words

Sphaeranthus africanus - Asteraceae - carvotanacetone derivatives - antimicrobial

References

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Prof. Dr. Consolacion Y. Ragasa

Chemistry Department and Center for Natural Sciences and Ecological Research
De La Salle University

2401 Taft Avenue

1004 Manila

Phillipines

Phone: + 63 25 36 02 30

Email: ragasac@dlsu.edu.ph