Planta Med 2009; 75(4): 378-380
DOI: 10.1055/s-0028-1112223
Natural Products Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antimicrobial Hasubanalactam Alkaloid from Stephania glabra

Deepak Kumar Semwal1 , Usha Rawat1
  • 1Department of Chemistry, University of Garhwal, Srinagar, Uttarakhand 246174, India
Further Information

Publication History

Received: June 30, 2008 Revised: November 15, 2008

Accepted: November 25, 2008

Publication Date:
15 January 2009 (online)

Abstract

A novel hasubanalactam alkaloid, named glabradine, has been isolated from the tubers of Stephania glabra, together with three known quaternary protoberberine alkaloids, palmatine, dehydrocorydalmine and stepharanine. The structure of glabradine was assigned as 7-O-demethyl-N,O-dimethyloxostephinine, by means of rigorous spectroscopic analysis including 2 D NMR measurements. It was evaluated for antimicrobial activity against Staphylococcus aureus, S. mutans, Microsporum gypseum, M. canis and Trichophyton rubrum and displayed potent antimicrobial activity superior to those of novobiocin and erythromycin used as positive controls.

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Dr. Deepak K. Semwal

Department of Chemistry

University of Garhwal

Srinagar

Uttarakhand 246174

India

Phone: +91-941-294-7995

Email: dr_dks.1983@yahoo.co.in