Risk factors for pulmonary complications after spine surgery

Table of Contents

ABSTRACT

 

Study design: Registry study with prospectively collected data

Objective: To determine risk factors for pulmonary complications in spine surgery.

Methods: The Spine End Results Registry 2003–2004 is an exhaustive database of 1,592 patients who underwent spine surgery at the University of Washington Medical Center or Harborview Medical Center. Detailed information regarding patient demographic, medical comorbidity, and comorbidities, surgical invasiveness and adverse outcomes were prospectively recorded. The primary outcome measure was the occurrence of a pulmonary complication following surgery. Univariate relative risks and 95 % confidence intervals for each of the risk factors were determined. Multivariate log binomial regression analysis was performed to investigate the association between each risk factor and a pulmonary complication, while controlling for other important risk factors.

Results: Altogether, there were 199 pulmonary complications after spine surgery. The cumulative incidence of a respiratory complication after spine surgery was 9 % (144 patients). Multivariate analysis suggested gender, chronic obstructive pulmonary disease, congestive heart failure, diabetes, age, diagnosis, surgical invasiveness and surgery in the thoracic spine are significant risk factors for pulmonary complications after spinal surgery.

Conclusions: The results of the present study suggest numerous statistically significant risk factors for pulmonary complications after spine surgery. These results may aid the clinician with preoperative risk stratification and patient counseling.

STUDY RATIONALE

While multiple studies have examined complication rates after spinal surgery, few studies have focused on risk factors for pulmonary complications after spine surgery. The rates of pulmonary complications after spine surgery has been reported to range from 0.9 % to 5 %, but methodology and definitions vary from study to study [1], [2], [3], [4].

OBJECTIVE

The objective of this study is to identify risk factors for pulmonary complications after spine surgery.

Figure 1 Patient selection and sampling

 

METHODS

Study design:

Registry study

Inclusion criteria:

All patients who underwent spinal surgery from January 1, 2003 to December 31, 2004 at Harborview Medical Center and the University of Washington Medical Center.

Exclusion criteria:

• Patients younger than 18 years of age

• Patients with incompletely recorded surgical invasiveness scores.

• Patients with surgical invasiveness scores of 0, as these included patients who did not undergo spinal surgery (Risser casting or closed reduction under general anesthesia).

Patient population:

The Spine End Results Registry at the University of Washington Medical Center is a prospectively recorded database of patients who underwent spinal surgery from January 1, 2003 to December 31, 2004 at Harborview Medical Center or the University of Washington Medical Center in Seattle WA. Detailed information with 2-year follow up regarding patient demographic, medical comorbidity, disease severity, surgical invasiveness and adverse outcomes were prospectively recorded as described by Mirza et al [5] (Table [1]). All patients were followed for at least 2 years prospectively for adverse occurrences.

Outcome:

The primary outcome measure was the occurrence of a pulmonary complication in the 2-year period after spinal surgery. A detailed list of all pulmonary complications with definitions used is summarized in Table [2].

Analysis:

• Categorical data were presented as number of events and percentages.

• Continuous data were presented as mean ± standard deviation.

• Univariate analysis evaluating the association between each categorical variable and a pulmonary complication was performed using Pearson’s Chi-square test or Fisher’s exact tests (where cell counts were low).

• Univariate analysis evaluating the association between each continuous variable and a pulmonary complication was performed using unpaired t-tests.

• Multivariate log-binomial regression was used to determine the association between each risk factor and a pulmonary complication, while controlling for other predictive factors.

• Risk factors were included in the multivariate log-binomial regression model if they were deemed of clinical importance by the study investigators or if their univariate association had a P-value < .10.

• We examined congestive heart failure, asthma, chronic obstructive pulmonary disease, and diabetes as individual risk factors and subsequently examined and adjusted the Charlson comorbidity score minus these two components to avoid conflagration of our risk calculation [7].

Table 1 Cohort characteristics

 

RESULTS

• Of the 1,745 patients, 38 were excluded because they were younger than 18 years of age and 100 were excluded for surgical invasiveness scores of 0 (Risser casting or closed reduction under general anesthesia). Fifteen had missing invasiveness scores, leaving 1,592 patients for analyses (Figure [1]).

• The mean age of the study population was 49.6 years. Thirty two percent smoked, 12 % were illicit drug users and 11 % had diabetes and 13 % had a defined past cardiac health history. We found degenerative cases to comprise 62 % of our study cohort, with 23 % to be traumatic. Posterior only surgery was performed in 59 % of patients, anterior only in 18 % of patients and revision surgery constituted 18 % of our patients (Table [1]).

• The cumulative incidence of pulmonary complication after spine surgery was 9 %. The incidence rate of pulmonary complications was 3.28 per 100 persons per year. There were 199 pulmonary complications after spine surgery (Table [2]).

• The mortality rate from pulmonary complications was 3.61 per 1,000 persons per year.

• In the univariate analysis, age older than 65, presence of smoking, diabetes, COPD, CHF, elevated Charlson comorbidity score, indication for surgery of nondegenerative nature (ie, trauma, tumors), cervical and thoracic level surgery compared to lumbar surgery, and increased surgical invasiveness were all statistically significant risk factors for pulmonary complication after spine surgery (Table [3]).

• In the multivariate analysis, male gender, COPD, CHF, Diabetes mellitus, age greater than 65 years, diagnosis (nondegenerative), thoracic level surgery and surgical invasiveness were statistically significant risk factors for pulmonary complication (Table [4]).

Table 2 Pulmonary adverse occurrence (AO)

 

Table 3 Univariate analysis of relative risk for pulmonary adverse occurrence (AO) following spine surgery

 

Table 4 Multivariate analysis of relative risk for pulmonary adverse occurrence

 

DISCUSSION

• We observed a cumulative incidence of pulmonary complications after spine surgery to be 9 %. Reported incidences after spine surgery range from 0.9 % to 5 %, but definitions of pulmonary complications and study populations vary from study to study [1] [2] [3] [4]. Our reported rate of pulmonary complications is nearly triple that of the highest previously reported incidence. A number of factors may contribute to this. Firstly, we recorded all pulmonary complications that occurred within two years after spine surgery. This inclusive approach likely contributes to the elevated rate of pulmonary complications that may not necessarily be related to the index spine procedure. The large patient population in our study reflects a very diverse patient population, including individuals with serious spinal disorders and major comorbidities who typically seek care in a tertiary care center like ours. This creates a negative selection bias from which tertiary care institutions like ours frequently experience when compared to institutions with very selective care approaches. In addition, the closer one looks at complications the more they appear to occur. As in any such study, identification of the amount of pulmonary complications led to the creation of care teams including perioperative medicine consult services and spine surgery anesthesia care teams to standardize care protocols and improve consistency of implementation of medical treatment recommendations.

• While many of these risk factors are intuitive, these data allow for quantification of these risks and may aid the clinician in decision making and counseling of patients.

• Strengths: Our large sample size and the quality of our data on several possible predictive variables for a pulmonary complication make this a very exhaustive analysis. Our analysis methods using multivariate regression allowed us estimate the effect of several risk factors on the probability of a pulmonary complication, while controlling for other possible predictive factors.

• Limitations: When groups are not randomized, selection bias comparing groups or risk factors may lead to a distortion of the findings based on confounding. Our data were collected prospectively using an ongoing spine registry created for enhanced quality assurance with monitoring and recording of all surgical activity, recording of preoperative baseline data and postoperative follow-up visits at defined intervals. We also identified several potential risk factors that may influence pulmonary complications and carefully controlled for them in a regression analysis. We feel this limits concerns regarding potential confounding.

• Future research should involve building prediction models whereby the probability of a complication can be predicted for each patient who undergoes spine surgery based on their composite of risk factors. This prediction model would need to be externally validated in another population of spine surgery patients.

SUMMARY AND CONCLUSIONS

• In this study, the cumulative incidence of pulmonary complication after spine surgery was 9 %.

• Risk factors for pulmonary complications after spine surgery include age greater than 65 years, diabetes, previous cardiac history, revision surgery, elevated Charlson morbidity score, greater surgical invasiveness.

REFERENCES

• 1 Carreon L Y, Puno R M, Dimar 2nd J R. et al . Perioperative complications of posterior lumbar decompression and arthrodesis in older adults.  J Bone Joint Surg Am. 2003;  85-A(11) 2089-2092
• 2 Deyo R A, Cherkin D C, Loeser J D. et al . Morbidity and mortality in association with operations on the lumbar spine. The influence of age, diagnosis, and procedure.  J Bone Joint Surg Am. 1992;  74(4) 536-543
• 3 Kalanithi P S, Patil C G, Boakye M. National complication rates and disposition after posterior lumbar fusion for acquired spondylolisthesis.  Spine. 2009;  34(18) 1963-1969
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• 5 Mirza S K, Deyo R A, Heagerty P J. et al . Towards standardized measurement of adverse events in spine surgery: conceptual model and pilot evaluation.  BMC Musculoskelet Disord. 2006;  7 53
• 6 Mirza S K, Deyo R A, Heagerty P J. et al . Development of an index to characterize the „invasiveness” of spine surgery: validation by comparison to blood loss and operative time.  Spine. 2008;  33(24) 2651-2661; discussion 2662
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EDITORIAL STAFF PERSPECTIVE

This is an excellent study regarding complications in spine surgery. We are unaware of a similar undertaking. Of course an interesting follow-up study would be to see if any specific care measures that have been changed by the investigators have reduced the incidence of pulmonary complications. This would require a prospective follow-up study.

The other point not directly addressed in this study is the influence of antibiotics, application of a standardized postoperative respiratory care protocol for known at-risk patients, and intraoperative anesthesiologic management of patients. For instance, presence of intraoperative hypotension, requiring resuscitation, the number of blood transfusions, fresh frozen plasma or colloids as well as type and duration of intravenous antibiotic prophylaxis may be variables to consider. These are variables which usually can not readily be gathered from a retrospective study.

 The value of a study like this, is that a potentially underestimated clinical problem can now be studied prospectively in a more detailed fashion. No doubt this study advances our awareness of pulmonary problems and more invasive spine surgery in an ill population.