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Synthesis 2009(7): 1113-1122  
DOI: 10.1055/s-0028-1088002
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Dendrimeric Tumor-Associated Mucin-Type Glycopeptide Antigens

Torsten Becker, Anton Kaiser, Horst Kunz*
Institut für Organische Chemie, Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany
Fax: +49(6131)3924786; e-Mail: hokunz@uni-mainz.de;
Further Information

Publication History

Received 1 October 2008
Publication Date:
06 March 2009 (online)

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Abstract

Tetravalent tumor-associated peptide and glycopeptide antigens representing partial sequences of the tandem repeat of mucin MUC4 and carrying the tumor-associated Tn saccharide side chain were synthesized on a di-lysyl-lysine core linked to the solid phase. The methodology was extended to the synthesis of an octameric tandem repeat glycopeptide of the particularly relevant tumor-associated mucin MUC1.

Key words

glycopeptides - multiple antigen presentation - solid-phase synthesis - dendrimers - tumor-associated antigens

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Novabiochem, Catalogue 2002-2003, p 204, Product-Nr. 05-24-0150, Calbiochem-Novabiochem (now Merck Biosciences), Schwalbach a. T., Germany.