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Synfacts 2009(3): 0303-0303  
DOI: 10.1055/s-0028-1087774
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides

Contributor(s): Hisashi Yamamoto, Pingfan Li
C.-J. Wang*, G. Liang, Z.-Y. Xue, F. Gao
Wuhan University, P. R. of China
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

A novel N,P-ligand is employed in the copper-catalyzed 1,3-dipolar cycloaddition of azomethine ylides giving the substituted pyrrolidine products in high yields and excellent enantio­selectivity. Significant improvement of substrate scope over previous studies is realized in this work.