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Synfacts 2009(3): 0244-0244  
DOI: 10.1055/s-0028-1087691
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ()-2-O-Methylneovibsanin H

Contributor(s): Philip Kocienski, Indu Dager
A. P.-J. Chen, C. M. Williams*
University of Queensland, Brisbane, Australia
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

This concise total synthesis of 2-O-methylneovibsanin features an acid-catalyzed four-step cascade (E → I) involving deprotection, Michael addition, solvolysis and Fischer esterification in one pot. This paper supports the biosynthesis route proposed by Fukuyama.