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Synfacts 2009(3): 0242-0242  
DOI: 10.1055/s-0028-1087687
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Dehydroaltenuene B

Contributor(s): Philip Kocienski, Zofia Komsta
D. Soorukram, T. Qu, A. G. M. Barrett*
Imperial College London, UK
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

Dehydroaltenuene B is a marine natural product which possesses some antibacterial activity. The focal step of this concise synthesis is the formation of the tricyclic core via a one-pot four-component benzyne coupling reaction (A → E).