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Synlett
DOI: 10.1055/a-2738-8420
DOI: 10.1055/a-2738-8420
Account
Selective Construction of Diverse Polycyclic Compounds by Electrophilic Cyclizations of Biaryl-Embedded 1,7-Enynes
Authors
Supported by: Instituto de Salud Carlos III RICORS2040 (RD24/0004/0008)
Supported by: Universidad de Alcalá predoctoral contract for L.S.-J.
We are grateful to MCIN/AEI/10.13039/501100011033 and European Union NextGeneration EU/PRTR for grant PID2023-146343NB-I00, to Instituto de Salud Carlos III (ISCIII) for grant RICORS2040 (RD24/0004/0008) co-funded by the European Union and to the University of Alcalá (predoctoral contract for L.S.-J.).
Abstract
Electrophilic cyclizations of biaryl-embedded 1,7-enynes enable the selective synthesis of dibenzofused polycycles with diverse topologies. The outcome strongly depends on the promoter—gold(I) complexes, Brønsted acids, or electrophilic boron reagents—as well as the substitution pattern of the enyne. This Account highlights recent advances and establishes a basis for future developments through the controlled design of substrates and activation modes.
Keywords
Biaryls - Boron - Brønsted acid - Electrophilic cyclizations - Enynes - Gold - Polycyclic compoundsPublication History
Received: 30 September 2025
Accepted after revision: 04 November 2025
Article published online:
18 November 2025
© 2025. Thieme. All rights reserved.
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For revisions, see:
For selected recent metal-catalyzed references, see:
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