Platelet NO/ROS Equilibrium—A Novel Mechanism for COVID-19 Related Thrombotic Events?

Thromb Haemost
DOI: 10.1055/a-2570-9093

Invited T&H Insights

Eli Israel Lev

¹Assuta Ashdod Medical Center and the Ben-Gurion University of the Negev, Ashdod, Israel

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¹Assuta Ashdod Medical Center and the Ben-Gurion University of the Negev, Ashdod, Israel

References
1 Bikdeli B, Madhavan MV, Jimenez D. et al; Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. J Am Coll Cardiol 2020; 75 (23) 2950-2973
2 Violi F, Harenberg J, Pignatelli P, Cammisotto V. COVID-19 and long-COVID thrombosis: from clinical and basic science to therapeutics. Thromb Haemost 2024; 124 (04) 286-296
3 Sevilya Z, Kuzmina A, Cipok M. et al. Differential platelet activation through an interaction with spike proteins of different SARS-CoV-2 variants. J Thromb Thrombolysis 2023; 56 (04) 538-547
4 Petito E, Guglielmini G, De Robertis D. et al. Platelets from COVID-19 show an altered nitric oxide/reactive oxygen species production balance. Thromb Haemost 2025