Direct Accessing γ-Pyridyl Tertiary Alcohols through Metal-Free Three-Component Reactions

Abstract

Herein, we introduce a novel method for synthesizing γ-pyridyl alcohols from readily accessible alcohols. This process is a metal-free, three-component reaction that elegantly combines alcohols, vinylarenes, and 4-cyanopyridine. The versatility of this reaction is showcased through its successful application in the late-stage functionalization of pharmaceutical molecules.

Key words

alcohols hydrogen atom transfer - metal-free - multicomponent reaction - benzophenone

Publikationsverlauf

Eingereicht: 25. Oktober 2024

Angenommen nach Revision: 11. Dezember 2024

Accepted Manuscript online:
11. Dezember 2024

Artikel online veröffentlicht:
31. Januar 2025

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