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DOI: 10.1055/a-2446-3557
Dearomative Carbonylations of Arenes via Bifunctional Coordination to Cr(CO)3
Autor*innen
We gratefully acknowledge the financial support from the National Natural Science Foundation of China (22271251 and 22471238), and the Fundamental Research Funds for the Central Universities (226-2023-00016 and 226-2024-00003).
Abstract
Carbonylation reactions serve as powerful tools to construct useful carbonyl compounds with high efficiency and atom economy. Compared with the well-developed carbonylation chemistry for alkenes, the dearomative carbonylation of arenes is largely underexplored, possibly owing to the severe challenge in overcoming resonance stabilization of arene π-systems. Bifunctional coordination to tricarbonylchromium not only offers a reliable strategy to activate inert benzene π-bonds towards dearomatizations but also provides the CO source for the carbonylation process. Herein, we highlight the recent progress in dearomative carbonylations of chromium-bound arenes through either the conventional nucleophile-electrophile addition mode or the newly-developed umpolung-enabled nucleophile-nucleophile addition mode under mild CO-gas-free conditions. Given the great abundance and diversity of arene substrates, we hope this review will attract more attention to this new direction of carbonylation chemistry.
1 Introduction
2 Dearomative Carbonylations of Arenes via Nucleophile-Electrophile Addition
3 Dearomative Carbonylations of Arenes via Nucleophile-Nucleophile Addition
4 Conclusion
Key words
arene - carbonylation - dearomatization - η6-coordination - chromium - aminocarbonylation - alkoxycarbonylation - carbamoylationPublikationsverlauf
Eingereicht: 25. September 2024
Angenommen: 21. Oktober 2024
Accepted Manuscript online:
21. Oktober 2024
Artikel online veröffentlicht:
12. November 2024
© 2024. Thieme. All rights reserved
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