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Synthesis
DOI: 10.1055/a-2359-8967
DOI: 10.1055/a-2359-8967
paper
Silver-Catalyzed Dearomative [3+2] Spiroannulation of Aryl Oxamic Acids with Alkynes
We are grateful for the financial support from the National Natural Science Foundation of China (22371255, 22371254, and 22071217), Natural Science Foundation of Zhejiang Province (LY22B020008, LZ23B020006), and the Fundamental Research Funds for the Provincial Universities of Zhejiang (RF-B2023003).
Abstract
A silver-catalyzed dearomative decarboxylative [3+2] spiroannulation of aryl oxamic acids with alkynes is described. The reaction provides reliable access to a range of azaspiro[4,5]trienones in moderate yields in aqueous media. In addition, the reaction exhibits a broad substrate scope and good functional group compatibility.
Key words
silver-catalyzed - dearomative - [3+2] spiroannulation - oxamic acid - alkyne - azaspiro[4,5]trienoneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2359-8967.
- Supporting Information
Publication History
Received: 03 June 2024
Accepted after revision: 03 July 2024
Accepted Manuscript online:
03 July 2024
Article published online:
24 July 2024
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