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DOI: 10.1055/a-2161-9689
A Simple and Powerful tert-Butylation of Carboxylic Acids and Alcohols
Abstract
A simple and safe tert-butylation reaction was developed. Treatment of various free amino acids with 1.1 equivalents of bis(trifluoromethanesulfonyl)imide in tert-butyl acetate directly afforded tert-butyl esters with free amino groups quickly and in good yields. In addition, various carboxylic acids and alcohols without amino groups were converted into tert-butyl esters and ethers, respectively, in high yields in the presence of small catalytic amounts of bis(trifluoromethanesulfonyl)imide. All tert-butylation reactions of free amino acids, carboxylic acids, and alcohols proceeded much faster and in higher yields compared with conventional methods.
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Key words
tert-butylation - amino acids - tert-butyl esters - tert-butyl ethers - bis(trifluoromethanesulfonyl)imideThe tert-butyl ester group is widely used as a protecting group for carboxylic acids due to its excellent stability against various nucleophiles and reducing agents, as well as its convenient deprotection under acidic conditions.[1] It is therefore frequently used as a protecting group for the carboxylic acid functionality of amino acids.[2] Common methods for the formation of tert-butyl esters include the condensation of carboxylic acids with tert-butanol[3] or with bubbling isobutene gas in the presence of concd H2SO4.[4] In addition, the use of various tert-butylating agents, including di-tert-butyl dicarbonate (Boc2O),[5] tert-butylisourea,[6] tert-butyl trichloroacetimidate,[7] N,N-dimethylformamide di-tert-butyl acetal,[8] 2-tert-butoxypyridine,[9] and tert-butyl acetoacetate,[10] as well as transesterification reactions[11] have been reported. However, these methods basically have to be conducted in organic solvents, and their applications to free amino acids that are insoluble in organic solvents are limited. There have been several examples of the direct formation of tert-butyl esters of free amino acids,[12] and the use of perchloric acid (HClO4) in tert-butyl acetate (t-BuOAc) is an often-used condition.[12a] [13] However, perchloric acid is a potentially hazardous reagent. Moreover, the reaction sometimes prematurely terminates, and yields and reaction rates also need to be improved. To proceed with the reaction efficiently, we considered it necessary to increase the solubility of free amino acids in organic solvents. The use of suitable organic acids to form salts was expected to increase solubility while also serving as an acid catalyst for tert-butylation reactions (Scheme [1]). Here, we report our investigations of various acids for the direct tert-butylation reaction of free amino acids.
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As a substrate for the tert-butylation reaction, we chose 2-hydroxy-4-aminobutyric acid (HABA) (5) because the tert-butyl-protected HABA (6) was required for our synthetic investigations involving natural phytosiderophore mugineic acid analogues. First, hydrophobic acids to increase the solubility of the salt of 5 were examined in the reaction using t-BuOAc as both the solvent and the tert-butylating reagent. The addition of diphenyl phosphate or p-toluenesulfonic acid (TsOH) did not result in dissolution of 5 in t-BuOAc, and the desired 6 was not obtained at all (Table [1], entries 1 and 2). Because fluorinated acids increase the solubility of salts, trifluoroacetic acid (TFA) was next examined. The addition of 50 equivalents of TFA resulted in the dissolution of 5 in t-BuOAc, but the yield of 6 was only 7% (entry 3), suggesting that the acidity of TFA was insufficient for the generation of a tert-butyl cation from t-BuOAc. Therefore, to increase acidity and solubility, the acid was changed to bis(trifluoromethanesulfonyl)imide (Tf2NH). Treatment with 2.0 equivalents of Tf2NH readily dissolved 5, and the reactivity was dramatically enhanced to complete the reaction within two hours, giving the desired di-tert-butylated product 6 in 68% isolated yield as its Tf2NH salt (entry 4). The Tf2NH was readily removed from the salt by washing with 10% aqueous ammonia solution to give the free amine. To address the potential issue of the formation of a five-membered lactam, compound 6 was purified and stored in the form of its Tf2NH salt and desalinated prior to its use. In addition, decreasing the number of equivalents of Tf2NH to 1.1 improved the yield to 86% (entry 5), and it was confirmed that the reaction was actually applicable on a gram scale. On the other hand, increasing the concentration in t-BuOAc (0.2 M) decreased the yield to 64% (entry 6). Furthermore, a similar reaction did not proceed at –20 °C (entry 7), and 6 was not obtained in other tert-butylating solvents such as t-BuOH or t-BuOMe (entries 8 and 9). On the other hand, Tf2NH did not dissolve 5 in dichloromethane (CH2Cl2), and bubbling isobutene gas through the CH2Cl2 solvent did not give 6 (entry 10). A similar fluorinated strong acid, trifluoromethanesulfonic acid (TfOH), also dissolved 5, although the resulting solution was slightly turbid, and 6 was obtained in 80% yield (entry 11). The conventional acid HClO4 also gave the desired 6, but the reaction was very slow and terminated prematurely; moreover, the yield was 61%, which is lower than that with Tf2NH or TfOH (entry 12). Other acids, such as H2SO4, HNO3, and CH3SO3H, did not give 6 (entries 13–15), suggesting that super-strong acidity is required in this reaction. The resulting 6 was used for the synthesis of mugineic acids and it was confirmed that racemization was not induced.
a Isolated yield.
b NMR yield using pyrazine as an internal standard.
c The reaction was performed at –20 °C.
d Isobutene gas was bubbled through CH2Cl2.
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With the optimized conditions established, the reaction was applied to various free amino acids. In this investigation, the resulting tert-butyl esters of amino acids were successfully converted back into free amino groups, as there were no concerns regarding lactam formations (Scheme [2]). The similar tert-butylation reactions of d-valine, l-leucine, and l-phenylalanine proceeded smoothly to give the desired tert-butyl esters 7, 8, and 9 with free amino groups in yields of 81, 74, and 86%, respectively. l-Phenylalanine tert-butyl ester 9 was converted into (+)- and (–)-Mosher amides, confirming that racemization had not occurred. Tert-butyl groups were easily introduced into free amino acids containing alcohol functionalities, resulting in the tert-butylation of both the carboxylic acid and alcohol groups. As a result, di-tert-butylated l-serine 10 was obtained in quantitative yield, whereas di-tert-butylated l-threonine 11 was obtained in 73% yield. In the case of amino acids possessing two carboxylic acid groups, such as l-aspartic acid and l-glutamic acid, both carboxylic acid groups were converted into their tert-butyl esters to give 12 and 13 in 77% yield and a modest yield, respectively. l-Cysteine, possessing a thiol group, also smoothly dissolved and reacted, and the analogue 14, in which the thiol group was also tert-butylated, was obtained in high yield. In the case of l-tyrosine which possesses a phenol group, product 15, in which only the carboxylic acid was tert-butylated, was obtained as the major product in 68% yield, and 16, in which both the phenol and the carboxylic acid group were tert-butylated, was also obtained as a minor product in 33% yield. On the other hand, the reaction of l-methionine was slow, and the desired tert-butyl ester 17 was obtained in only 7% yield as a Tf2NH salt. This substrate-scope investigation revealed that the tert-butylation reaction was applicable to various amino acids[14] other than l-methionine, due to the presence of the sulfide group.
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In the tert-butylation reaction of free amino acids, 1.0 equivalent of Tf2NH was used for the soluble salt formation with amino groups, and the remaining 0.1 equivalent of Tf2NH made the reaction proceed. Therefore, a small catalytic amount of Tf2NH is considered sufficient for the tert-butylation reaction of carboxylic acids that do not have free amino groups. Thus, the Tf2NH-catalyzed tert-butylation reaction was applied to various carboxylic acids (Scheme [3]). The conversion of hydrocinnamic acid, a simple carboxylic acid, into its tert-butyl ester 18 was achieved with just 2 mol% of Tf2NH, resulting in a 76% yield. A carboxylic acid possessing a ketone group was also converted into tert-butyl ester 19 in 79% yield by 5 mol% of Tf2NH, without affecting the ketone group. A bromo group also tolerated the reaction condition, and the tert-butyl ester 20 was obtained by treatment with 10 mol% of Tf2NH in 66% yield. A tertiary carboxylic acid and benzoic acid were also tert-butylated under catalytic conditions to give 21 and 22, respectively, in modest yields. The catalytic conditions were applicable to N-Cbz-protected amino acids, and the tert-butylation reactions of N-Cbz-l-serine and N-Cbz-l-azetidine-2-carboxylic acid were catalyzed by 5 mol% of Tf2NH to afford 23 and 24 in yields of 89 and 81%, respectively. Thus, the Tf2H-catalyzed reaction was found to be applicable to various carboxylic acids that do not possess functional groups that could quench Tf2NH, such as amino groups.[15]
Next, the catalytic conditions for the tert-butylation reaction were applied to alcohols. Although there have been several examples of the tert-butylation of alcohols,[16] the present reaction was expected to reduce both the catalyst loading and reaction time due to the high activity of Tf2NH. As the tert-butyl ethers of small alcohols are volatile and difficult to handle, high-molecular-weight alcohols were investigated this time (Scheme [4]). The Tf2NH-catalyzed reaction of alcohols proceeded much faster than occurred with carboxylic acids. The reaction of decanol in the presence of only 2 mol% of Tf2NH proceeded smoothly to afford tert-butyl ether 25 in 94% yield. In the presence of 1 mol% Tf2NH, benzyl alcohol underwent conversion to tert-butyl ether 26 with a yield of 75%. Importantly, no significant decomposition occurred due to the generation of the benzyl cation. Treatment by 1 mol% of Tf2NH of a propargyl alcohol afforded 27 in quantitative yield. In the case of diols, both alcohol groups were converted into tert-butyl ethers regardless of whether they were alkyl or propargyl alcohols, and di-tert-butyl ethers 28 and 29 were obtained in yields of 90 and 93%, respectively. The reaction of allylic alcohols also proceeded smoothly, and the allylic tert-butyl ether 30 was obtained in 88% yield. On the other hand, the reaction of phenol analogues stopped prematurely, as in the case of tyrosine 16, and the tert-butyl ether 31 was obtained in only 34% yield. Thus, it was revealed that the tert-butylation reaction of alcohols other than phenols proceeded smoothly and in high yields with very small amounts of Tf2OH (1–2 mol%).[17]
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Finally, the Tf2NH-catalyzed tert-butylation reaction was compared with the conventional method (Scheme [5]). Previously, we prepared 34 from l-malic acid for the synthesis of natural phytosiderophoric mugineic acids[18] and the modified mugineic acid, proline deoxymugineic acid (PDMA), as fertilizers for desert soils.[16] The acetonide 32 derived from l-malic acid was heated to reflux in acetic acid and H2O to remove the acetonide group, and the solution was directly evaporated to give crude 33. Isobutene gas was bubbled through the dichloromethane solution of the resultant 33 in the presence of H2SO4 to give 34 in 64% yield.[19] This method actually gave 34 on a gram scale, but repeated bubbling of isobutene gas was required and the reaction needed a very long time (7 days).[16] When we repeated the previous tert-butylation reaction and quenched at six days, 34 was obtained in 59% yield. On the other hand, the Tf2NH-catalyzed tert-butylation reaction of 33 proceeded much faster to give 34 in a very short time (3 h) with a higher (78%) yield (Scheme [5]) (see the Supplementary Information, Scheme S1, for the time course of these reactions).
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In conclusion, a simple and safe tert-butylation reaction has been developed. The reaction employs Tf2NH as a reagent to generate soluble salts by reacting with the amino groups of amino acids in an organic solvent. Tf2NH also acted as a strong acid in this process. Additionally, tert-butyl acetate was used as both the solvent and the tert-butylation agent. The reaction enabled the direct conversion of free amino acids into tert-butyl esters. In addition, in the case of various carboxylic acids and alcohols without amino groups, a small catalytic amount of Tf2NH was sufficient to convert them into tert-butyl esters and ethers in high yields. All tert-butylation reactions of free amino acids, carboxylic acids, and alcohols proceeded much faster and in higher yields than did the conventional methods. The method developed in this study is a potential alternative to the conventional use of perchloric acid, simply by replacing it with bis(trifluoromethanesulfonyl)imide. However, this simple replacement dramatically increased the reaction rates and yields while providing safe conversions. Therefore, the authors consider that this information should be shared with a wide range of synthetic organic chemists.
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Conflict of Interest
2-Hydroxy-4-aminobutyric acid (HABA) (5) was provided by Aichi Steel Corporation, which is conducting cooperative research on the development of fertilizers for alkaline soils based on phytosiderophore mugineic acid analogues.
Acknowledgment
We thank to Drs. M. Suzuki and A. Mera of Aichi Steel Corporation for providing 2-hydroxy-4-amino butyric acid (HABA) (5).
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a- 2161-9689.
- Supporting Information
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References and Notes
- 1a Wuts PG. M. Greene’s Protective Groups in Organic Synthesis, 5th ed. Wiley; New York: 2014
- 1b Isidro-Llobet A, Álvarez M, Albericio F. Chem. Rev. 2009; 109: 2455
- 2a Fukase K, Kitazawa M, Sano A, Shimbo K, Horimoto S, Fujita H, Kubo A, Wakamiya T, Shiba T. Bull. Chem. Soc. Jpn. 1992; 65: 2227
- 2b Boger DL, Borzilleri RM, Nukui S. J. Org. Chem. 1996; 61: 3561
- 2c Fiore PJ, Puls TP, Walker JC. Org. Process Res. Dev. 1998; 2: 151
- 2d Huang H, Martásek P, Roman LJ, Silverman RB. J. Med. Chem. 2000; 43: 2938
- 2e Smith AB. III, Cho YS, Ishiyama H. Org. Lett. 2001; 3: 3971
- 2f Namba K, Kobayashi K, Murata Y, Hirakawa H, Yamagaki T, Iwashita T, Nishizawa M, Kusumoto S, Tanino K. Angew. Chem. Int. Ed. 2010; 49: 9956
- 2g Muramatsu W, Yamamoto H. J. Am. Chem. Soc. 2019; 141: 18926
- 2h Muramatsu M, Yamamoto H. J. Am. Chem. Soc. 2021; 143: 6792
- 3a Murphy CF, Koehler RE. J. Org. Chem. 1970; 35: 2429
- 3b Inanaga J, Hirata K, Saeki H, Katsuki T, Yamaguchi M. Bull. Chem. Soc. Jpn. 1979; 52: 1989
- 3c Fujisawa T, Mori T, Fukumoto K, Sato T. Chem. Lett. 1982; 11: 1891
- 3d Ohta S, Shimabayashi A, Aona M, Okamoto M. Synthesis 1982; 833
- 3e Dhaon MK, Olsen RK, Ramasamy K. J. Org. Chem. 1982; 47: 1962
- 3f Crowther GP, Kaiser EM, Woodruff RA, Hauser CR. Org. Synth. Coll. Vol. VI 1988; 259
- 4a Anderson GW, Callahan FM. J. Am. Chem. Soc. 1960; 82: 3359
- 4b McCloskey AL, Fonken GS, Kluiber RW, Johnson WS. Org. Synth. Coll. Vol. IV . Wiley; London: 1963: 261
- 4c Valerio RM, Alewood PF, Johns RB. Synthesis 1988; 786
- 5a Takeda K, Akiyama A, Nakamura H, Takizawa S, Mizuno Y, Takayanagi H, Harigaya Y. Synthesis 1994; 1063
- 5b Kaur A, Pannu A, Brar DS, Mehta SK. Salunke D. B. ACS Omega 2020; 5: 21007
- 6 Burk RM, Berger GD, Buginanesi RL, Girotra NN, Parsons WH, Ponpipom MM. Tetrahedron Lett. 1993; 34: 975
- 7 Armstrong A, Brackenridge I, Jackson RF, Kirk JM. Tetrahedron Lett. 1988; 29: 2483
- 8 Widmer U. Synthesis 1983; 135
- 9 La MT, Kim H.-K. Tetrahedron 2018; 74: 3748
- 10 Taber DF, Gerstenhaber DA, Zhao X. Tetrahedron Lett. 2006; 47: 3065
- 11a Chavan SP, Zubaidha PK, Dantale SW, Keshavaraja A, Ramaswamy AV, Ravindranathan T. Tetrahedron Lett. 1996; 37: 233
- 11b Vasin VA, Razin VV. Synlett 2001; 658
- 11c Horikawa R, Fujimoto C, Yazaki R, Ohshima T. Chem. Eur. J. 2016; 22: 12278
- 12a Taschner E, Chimiak A, Bator B, Sokołowska T. Liebigs Ann. Chem. 1961; 646: 134
- 12b Roeske R. J. Org. Chem. 1963; 28: 1251
- 12c Mangia A, Scandroglio A, Del Buttero P. Org. Prep. Proced. Int. 1986; 18: 13
- 12d Mallesha N, Rao SP, Suhas R, Gowda C. Tetrahedron Lett. 2012; 53: 641
- 13a Liu L, Tanke RS, Miller MJ. J. Org. Chem. 1986; 51: 5332
- 13b Whitten JP, Muench D, Cube RV, Nyce PL, Baron BM, McDonald IA. Bioorg. Med. Chem. Lett. 1991; 1: 441
- 13c Hu J, Miller MJ. J. Am. Chem. Soc. 1997; 119: 3462
- 13d Jang JH, Lee H, Sharma A, Lee SM, Lee TH, Kang C, Kim JS. Chem. Commun. 2016; 52: 9965
- 13e Zemskov I, Altaner S, Dietrich DR, Wittmann V. J. Org. Chem. 2017; 82: 3680
- 13f Leygue N, Enel M, Diallo A, Mestre-Voegtlé B, Galaup C, Picard C. Eur. J. Org. Chem. 2019; 2899
- 14 tert-Butyl 4-Amino-2-tert-butoxybutanoate (6); Typical Procedure A suspension of 2-hydroxy-4-aminobutyric acid (HABA; 5; 2.15 g, 18.0 mmol) in t-BuOAc (180 mL, 0.1 M) was cooled to 0 °C. and a solution of Tf2NH (5.58 g, 19.8 mmol) in CH2Cl2 (27 mL) at 0 °C was added to the suspension. The resulting mixture was stirred at 0 °C for 2.5 h and then slowly added to sat. aq NaHCO3 (350 mL) at 0 °C (reverse addition). The mixture was extracted with CH2Cl2 (3 × 500 mL), and the combined organic layers were dried (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography [silica gel, hexane–EtOAc (5:1, 2:1, to 0:1)] to give a white deliquescent Tf2NH salt; yield: 8.1 g (86%). IR (KBr): 3187, 2980, 1721, 1621, 1350, 1229, 1197 cm–1. 1H NMR (500 MHz, CD3OD): δ = 4.15 (dd, J = 7.3, 4.4 Hz, 1 H), 3.01 (td, J = 6.4, 1.5 Hz, 2 H), 2.03–1.85 (m, 2 H), 1.49 (s, 9 H), 1.21 (s, 9 H). 13C NMR (125 MHz, CD3OD): δ = 174.6, 125.0 (q), 122.5 (q), 119.9 (q), 117.4 (q), 83.2, 76.9, 71.0, 37.9, 32.3, 28.1, 28.0. HRMS-ESI: m/z [M + H]+ calcd for C14H27F6N2O7S2: 513.1164; found: 513.1155. For the procedure to give 6 with a free amino group, see the Supporting Information.
- 15 tert-Butyl 3-Phenylpropanoate (18); Typical Procedure A solution of Tf2NH (3.3 mg, 0.012 mmol) in CH2Cl2 (0.15 mL) at 0 °C was added to a solution of hydrocinnamic acid (88.1 mg, 0.587 mmol) in t-BuOAc (5.9mL, 0.1 M). The mixture was stirred at 0 °C for 16 h, then slowly added to sat. aq NaHCO3 (7 mL) at 0 °C. The mixture was extracted with CH2Cl2 (3 × 20 mL), and the combined organic layers were dried (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography [silica gel, hexane–EtOAc (1:0, 20:1, to 10:1)] to give a colorless oil; yield: 92 mg (76%). IR (KBr): 2978, 1732, 1367, 1147 cm–1. 1H NMR (500 MHz, CDCl3): δ = 7.34–7.28 (m, 2 H), 7.23–7.16 (m, 3 H), 2.91 (t, J = 7.6 Hz, 2 H), 2.54 (t, J = 7.6 Hz, 2 H), 1.41 (s, 9 H). 13C NMR (125 MHz, CDCl3): δ = 172.4, 140.9, 128.5, 128.4, 126.2, 80.4, 37.2, 31.2, 28.2. HRMS-ESI: m/z [M + H]+ calcd for C13H19O2: 207.1385; found: 207.1393.
- 16a Barge A, Occhiato EG, Prandi C, Scarpi D, Tabasso S, Venturello P. Synlett 2010; 0812
- 16b Salvati A, Hubley CT, Albiniak PA. Tetrahedron Lett. 2014; 55: 7133
- 16c Yamada K, Hayakawa N, Fujita H, Kitamura M, Kunishima M. Eur. J. Org. Chem. 2016; 4093
- 16d Fandrick KR, Patel ND, Radomkit S, Chatterjee A, Braith S, Fandrick DR, Busacca CA, Senanayake CH. J. Org. Chem. 2021; 86: 4877
- 17 1,6-Di-tert-butoxyhexane (29); Typical Procedure A solution of Tf2NH (6.6 mg, 0.023 mmol) in CH2Cl2 (0.15 mL) at 0 °C was added to a solution of hexane-1,6-diol (139 mg, 1.17 mmol) in t-BuOAc (11.7 mL, 0.1 M). The mixture was stirred at 0 °C for 16 and then slowly added to sat. aq NaHCO3 (20 mL) at 0 °C. The mixture was extracted with CH2Cl2 (3 × 30 mL), and the combined organic layers were dried (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography [silica gel, hexane–EtOAc (0:1, 20:1, to 10:1)] to give a colorless oil; yield: 250 mg (93%). IR (KBr): 2974, 1361, 1199, 1083 cm–1. 1H NMR (500 MHz, CD3OD): δ = 3.32 (t, J = 6.8 Hz, 4 H), 1.56–1.47 (m, 4 H), 1.38–1.30 (m, 4 H), 1.18 (s, 18 H). 13C NMR (125 MHz, CDCl3): δ = 72.4, 61.6, 30.8, 27.7, 26.2. HRMS-ESI: m/z [M + H]+ calcd for C14H31O2: 231.2324; found: 231.2315.
- 18 Namba K, Murata Y, Horikawa M, Iwashita T, Kusumoto S. Angew. Chem. Int. Ed. 2007; 46: 7060
- 19 Suzuki M, Urabe A, Sasaki S, Tsugawa R, Nishio S, Mukaiyama H, Murata Y, Masuda H, Aung MS, Mera A, Takeuchi M, Fukushima K, Kanaki M, Kobayashi K, Chiba Y, Shrestha BB, Nakanishi H, Watanabe T, Nakayama A, Fujino H, Kobayashi T, Tanino K, Nishizawa NK, Namba K. Nat. Commun. 2021; 12: 1558
For selected examples, see:
For selected examples, see:
For selected examples, see:
Corresponding Author
Publication History
Received: 08 August 2023
Accepted after revision: 29 August 2023
Accepted Manuscript online:
29 August 2023
Article published online:
09 October 2023
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References and Notes
- 1a Wuts PG. M. Greene’s Protective Groups in Organic Synthesis, 5th ed. Wiley; New York: 2014
- 1b Isidro-Llobet A, Álvarez M, Albericio F. Chem. Rev. 2009; 109: 2455
- 2a Fukase K, Kitazawa M, Sano A, Shimbo K, Horimoto S, Fujita H, Kubo A, Wakamiya T, Shiba T. Bull. Chem. Soc. Jpn. 1992; 65: 2227
- 2b Boger DL, Borzilleri RM, Nukui S. J. Org. Chem. 1996; 61: 3561
- 2c Fiore PJ, Puls TP, Walker JC. Org. Process Res. Dev. 1998; 2: 151
- 2d Huang H, Martásek P, Roman LJ, Silverman RB. J. Med. Chem. 2000; 43: 2938
- 2e Smith AB. III, Cho YS, Ishiyama H. Org. Lett. 2001; 3: 3971
- 2f Namba K, Kobayashi K, Murata Y, Hirakawa H, Yamagaki T, Iwashita T, Nishizawa M, Kusumoto S, Tanino K. Angew. Chem. Int. Ed. 2010; 49: 9956
- 2g Muramatsu W, Yamamoto H. J. Am. Chem. Soc. 2019; 141: 18926
- 2h Muramatsu M, Yamamoto H. J. Am. Chem. Soc. 2021; 143: 6792
- 3a Murphy CF, Koehler RE. J. Org. Chem. 1970; 35: 2429
- 3b Inanaga J, Hirata K, Saeki H, Katsuki T, Yamaguchi M. Bull. Chem. Soc. Jpn. 1979; 52: 1989
- 3c Fujisawa T, Mori T, Fukumoto K, Sato T. Chem. Lett. 1982; 11: 1891
- 3d Ohta S, Shimabayashi A, Aona M, Okamoto M. Synthesis 1982; 833
- 3e Dhaon MK, Olsen RK, Ramasamy K. J. Org. Chem. 1982; 47: 1962
- 3f Crowther GP, Kaiser EM, Woodruff RA, Hauser CR. Org. Synth. Coll. Vol. VI 1988; 259
- 4a Anderson GW, Callahan FM. J. Am. Chem. Soc. 1960; 82: 3359
- 4b McCloskey AL, Fonken GS, Kluiber RW, Johnson WS. Org. Synth. Coll. Vol. IV . Wiley; London: 1963: 261
- 4c Valerio RM, Alewood PF, Johns RB. Synthesis 1988; 786
- 5a Takeda K, Akiyama A, Nakamura H, Takizawa S, Mizuno Y, Takayanagi H, Harigaya Y. Synthesis 1994; 1063
- 5b Kaur A, Pannu A, Brar DS, Mehta SK. Salunke D. B. ACS Omega 2020; 5: 21007
- 6 Burk RM, Berger GD, Buginanesi RL, Girotra NN, Parsons WH, Ponpipom MM. Tetrahedron Lett. 1993; 34: 975
- 7 Armstrong A, Brackenridge I, Jackson RF, Kirk JM. Tetrahedron Lett. 1988; 29: 2483
- 8 Widmer U. Synthesis 1983; 135
- 9 La MT, Kim H.-K. Tetrahedron 2018; 74: 3748
- 10 Taber DF, Gerstenhaber DA, Zhao X. Tetrahedron Lett. 2006; 47: 3065
- 11a Chavan SP, Zubaidha PK, Dantale SW, Keshavaraja A, Ramaswamy AV, Ravindranathan T. Tetrahedron Lett. 1996; 37: 233
- 11b Vasin VA, Razin VV. Synlett 2001; 658
- 11c Horikawa R, Fujimoto C, Yazaki R, Ohshima T. Chem. Eur. J. 2016; 22: 12278
- 12a Taschner E, Chimiak A, Bator B, Sokołowska T. Liebigs Ann. Chem. 1961; 646: 134
- 12b Roeske R. J. Org. Chem. 1963; 28: 1251
- 12c Mangia A, Scandroglio A, Del Buttero P. Org. Prep. Proced. Int. 1986; 18: 13
- 12d Mallesha N, Rao SP, Suhas R, Gowda C. Tetrahedron Lett. 2012; 53: 641
- 13a Liu L, Tanke RS, Miller MJ. J. Org. Chem. 1986; 51: 5332
- 13b Whitten JP, Muench D, Cube RV, Nyce PL, Baron BM, McDonald IA. Bioorg. Med. Chem. Lett. 1991; 1: 441
- 13c Hu J, Miller MJ. J. Am. Chem. Soc. 1997; 119: 3462
- 13d Jang JH, Lee H, Sharma A, Lee SM, Lee TH, Kang C, Kim JS. Chem. Commun. 2016; 52: 9965
- 13e Zemskov I, Altaner S, Dietrich DR, Wittmann V. J. Org. Chem. 2017; 82: 3680
- 13f Leygue N, Enel M, Diallo A, Mestre-Voegtlé B, Galaup C, Picard C. Eur. J. Org. Chem. 2019; 2899
- 14 tert-Butyl 4-Amino-2-tert-butoxybutanoate (6); Typical Procedure A suspension of 2-hydroxy-4-aminobutyric acid (HABA; 5; 2.15 g, 18.0 mmol) in t-BuOAc (180 mL, 0.1 M) was cooled to 0 °C. and a solution of Tf2NH (5.58 g, 19.8 mmol) in CH2Cl2 (27 mL) at 0 °C was added to the suspension. The resulting mixture was stirred at 0 °C for 2.5 h and then slowly added to sat. aq NaHCO3 (350 mL) at 0 °C (reverse addition). The mixture was extracted with CH2Cl2 (3 × 500 mL), and the combined organic layers were dried (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography [silica gel, hexane–EtOAc (5:1, 2:1, to 0:1)] to give a white deliquescent Tf2NH salt; yield: 8.1 g (86%). IR (KBr): 3187, 2980, 1721, 1621, 1350, 1229, 1197 cm–1. 1H NMR (500 MHz, CD3OD): δ = 4.15 (dd, J = 7.3, 4.4 Hz, 1 H), 3.01 (td, J = 6.4, 1.5 Hz, 2 H), 2.03–1.85 (m, 2 H), 1.49 (s, 9 H), 1.21 (s, 9 H). 13C NMR (125 MHz, CD3OD): δ = 174.6, 125.0 (q), 122.5 (q), 119.9 (q), 117.4 (q), 83.2, 76.9, 71.0, 37.9, 32.3, 28.1, 28.0. HRMS-ESI: m/z [M + H]+ calcd for C14H27F6N2O7S2: 513.1164; found: 513.1155. For the procedure to give 6 with a free amino group, see the Supporting Information.
- 15 tert-Butyl 3-Phenylpropanoate (18); Typical Procedure A solution of Tf2NH (3.3 mg, 0.012 mmol) in CH2Cl2 (0.15 mL) at 0 °C was added to a solution of hydrocinnamic acid (88.1 mg, 0.587 mmol) in t-BuOAc (5.9mL, 0.1 M). The mixture was stirred at 0 °C for 16 h, then slowly added to sat. aq NaHCO3 (7 mL) at 0 °C. The mixture was extracted with CH2Cl2 (3 × 20 mL), and the combined organic layers were dried (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography [silica gel, hexane–EtOAc (1:0, 20:1, to 10:1)] to give a colorless oil; yield: 92 mg (76%). IR (KBr): 2978, 1732, 1367, 1147 cm–1. 1H NMR (500 MHz, CDCl3): δ = 7.34–7.28 (m, 2 H), 7.23–7.16 (m, 3 H), 2.91 (t, J = 7.6 Hz, 2 H), 2.54 (t, J = 7.6 Hz, 2 H), 1.41 (s, 9 H). 13C NMR (125 MHz, CDCl3): δ = 172.4, 140.9, 128.5, 128.4, 126.2, 80.4, 37.2, 31.2, 28.2. HRMS-ESI: m/z [M + H]+ calcd for C13H19O2: 207.1385; found: 207.1393.
- 16a Barge A, Occhiato EG, Prandi C, Scarpi D, Tabasso S, Venturello P. Synlett 2010; 0812
- 16b Salvati A, Hubley CT, Albiniak PA. Tetrahedron Lett. 2014; 55: 7133
- 16c Yamada K, Hayakawa N, Fujita H, Kitamura M, Kunishima M. Eur. J. Org. Chem. 2016; 4093
- 16d Fandrick KR, Patel ND, Radomkit S, Chatterjee A, Braith S, Fandrick DR, Busacca CA, Senanayake CH. J. Org. Chem. 2021; 86: 4877
- 17 1,6-Di-tert-butoxyhexane (29); Typical Procedure A solution of Tf2NH (6.6 mg, 0.023 mmol) in CH2Cl2 (0.15 mL) at 0 °C was added to a solution of hexane-1,6-diol (139 mg, 1.17 mmol) in t-BuOAc (11.7 mL, 0.1 M). The mixture was stirred at 0 °C for 16 and then slowly added to sat. aq NaHCO3 (20 mL) at 0 °C. The mixture was extracted with CH2Cl2 (3 × 30 mL), and the combined organic layers were dried (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography [silica gel, hexane–EtOAc (0:1, 20:1, to 10:1)] to give a colorless oil; yield: 250 mg (93%). IR (KBr): 2974, 1361, 1199, 1083 cm–1. 1H NMR (500 MHz, CD3OD): δ = 3.32 (t, J = 6.8 Hz, 4 H), 1.56–1.47 (m, 4 H), 1.38–1.30 (m, 4 H), 1.18 (s, 18 H). 13C NMR (125 MHz, CDCl3): δ = 72.4, 61.6, 30.8, 27.7, 26.2. HRMS-ESI: m/z [M + H]+ calcd for C14H31O2: 231.2324; found: 231.2315.
- 18 Namba K, Murata Y, Horikawa M, Iwashita T, Kusumoto S. Angew. Chem. Int. Ed. 2007; 46: 7060
- 19 Suzuki M, Urabe A, Sasaki S, Tsugawa R, Nishio S, Mukaiyama H, Murata Y, Masuda H, Aung MS, Mera A, Takeuchi M, Fukushima K, Kanaki M, Kobayashi K, Chiba Y, Shrestha BB, Nakanishi H, Watanabe T, Nakayama A, Fujino H, Kobayashi T, Tanino K, Nishizawa NK, Namba K. Nat. Commun. 2021; 12: 1558
For selected examples, see:
For selected examples, see:
For selected examples, see:
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