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DOI: 10.1055/a-2125-0025
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients
TRIAL REGISTRATION: Registration number (trial ID): NCT05174845, Trial registry: ClinicalTrials.gov (http://www.clinicaltrials.gov/), Type of Study: observational, retrospective, multicenter
Abstract
Background and study aims Effective bowel cleansing is critical for detecting lesions during colonoscopy, highlighting the importance of bowel preparations. 1L polyethylene glycol (PEG) + ascorbate (Asc) is the only recommended 1L PEG product in Europe and the United States. Its efficacy was demonstrated in large-scale controlled trials and confirmed in smaller-scale real-world studies. However, no large-scale real-world data exist.
Patients and methods This observational, retrospective, multicenter study, used outpatient follow-up data from medical records from 10 centers in Spain and two in Portugal. Outpatients aged ≥18 years using 1L PEG + Asc as bowel preparation were included. The main outcome measures were overall adequate colon cleansing (Boston Bowel Preparation Scale [BBPS] score ≥6 with BBPS score ≥2 in each segment) and high-quality cleansing of the right colon (BBPS score=3).
Results Data from 13169 eligible patients were included. Overall cleansing success was achieved in 89.3% (95%CI 88.7%-89.8%) and high-quality cleansing in the right colon in 49.3% (95%CI 48.4%–50.2%) of patients. For the overnight split-dose and same-day regimens, overall adequate quality cleansing success rate was 94.7% and 86.7% (P<0.0001) and high-quality cleansing of the right colon rate was 65.4% and 41.4% (P<0.0001), respectively. Colonoscopy was completed in 97.3% of patients, with non-completion due to poor preparation in only 0.8%; 2.3% of patients experienced at least one adverse event (AE).
Conclusions This large-scale, real-world study demonstrates the effectiveness of 1L PEG + Asc in the total and right colon, with a low percentage of patients with AEs in routine clinical practice.
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Introduction
Effective bowel preparation is critical for a successful colonoscopy. High standards of cleansing improve diagnostic accuracy, resulting in a faster, less technically difficult procedure, which decreases the need for repeat colonoscopy and reduces the cost burden [1] [2] [3] [4] [5]. Two essential quality indicators for colonoscopy, the adenoma detection rate (ADR) and the cecal intubation rate (CIR), are strongly influenced by bowel preparation quality, and high levels of cleansing are necessary for optimal detection of sessile serrated adenomas [2] [6] [7]. A retrospective study assessing the ADR in patients who underwent a repeat colonoscopy owing to inadequate cleansing found that 33.8% of individuals had at least one adenoma that was missed in the initial screening, highlighting the clinical necessity of achieving high levels of bowel cleansing [8].
Traditional polyethylene glycol (PEG)-based bowel preparations are effective at delivering successful bowel cleansing but, with poor palatability and the consumption of up to 4 L of solution required, there is potential for reduced compliance and cleansing performance [9] [10] [11]. The introduction of the asymmetrically dosed 1-L PEG and ascorbate bowel preparation (1L PEG + Asc) (PLENVU, Norgine, Harefield, UK) in Portugal in 2017 and Spain in 2018 provided the first 1L PEG-based formulation that was specifically designed for effective bowel preparation at an ultra-low volume. This is done by delivering two doses with different formulations, with a high ascorbate content in the second dose.
1L PEG + Asc is currently the only approved and recommended 1L PEG product in Europe and the United States, thanks to three large-scale Phase 3 randomized controlled trials (RCTs) [12] [13] [14]. Across the trials, 1L PEG + Asc demonstrated at least non-inferior cleansing of the overall colon compared with comparator preparations, and superior high-quality cleansing of the right colon was observed compared with 2L PEG + Asc (MORA study) [13]. High-quality cleansing in the right colon was a co-primary endpoint in all the trials and is an important factor when determining cleansing performance for screening colonoscopy, due to the higher proportions of missed and flat adenomas in this anatomical location [15]. A recent Phase 4 study also confirmed that cleansing with 1L PEG + Asc was non-inferior to 4L PEG and associated with improved compliance [16].
Real-world study reports indicate that the performance of 1L PEG + Asc in clinical trials is replicated in the less well-controlled setting of clinical practice, where patients may have more co-morbidities associated with reduced bowel cleansing efficacy or safety [17] [18] [19]. Over 2020 and 2021, four studies reported on 1L PEG + Asc in a real-world setting on a relatively small scale and showed good efficacy, safety, and adherence rates [20] [21] [22] [23].
Our objective was to evaluate the effectiveness and safety of 1L PEG + Asc bowel preparation for colonoscopy in routine clinical practice in a large number of patients. We conducted an observational, multicenter, retrospective study across 12 sites in Spain and Portugal, evaluating >13000 patients who received 1L PEG + Asc as part of a routine colonoscopy procedure.
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Patients and methods
Study design
This observational, retrospective, multicenter study was based on a review of outpatient follow-up data from existing medical records. The study was approved by the Hospital Clínico San Carlos Ethical Review Committee and registered in an international clinical trials registry (ClinicalTrials.gov). Data were anonymized by center to minimize the risk of individual patient data being identified.
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Study population
Outpatients ≥18 years of age who underwent a screening, follow-up or diagnostic colonoscopy between June 1, 2019 and September 1, 2021, who used 1L PEG + Asc as preparation for the colonoscopy were included. Data were taken from 12 centers in Spain and Portugal. 1L PEG + Asc preparation was taken as recommended in the Summary of Product Characteristics, either in an overnight split-dose regimen (i.e. the first dose taken in the evening before the clinical procedure and the second dose in the morning of the day of the clinical procedure, approximately 12 hours after the start of the first dose) or in a same-day regimen (i.e. both doses taken in the morning of the day of the clinical procedure, with the second dose being taken a minimum of 2 hours after the start of the first dose). Although split dose is generally recommended, a same-day bowel preparation may represent an acceptable alternative to split dosing, especially for afternoon colonoscopies, based on previous results [24]. All patients were instructed to follow a fiber-free diet for at least 24 hours prior to the colonoscopy preparation. Written instructions on how to consume the bowel preparation were provided by each hospital.
Patients were excluded if they had a history of colorectal cancer or colectomy before the first colonoscopy, or if any of the following mandatory data were not available: sex; age; indication for colonoscopy; dosing regimen; complete colonoscopy; Boston Bowel Preparation Scale (BBPS) of the right colon (includes cecum and ascending colon); BBPS score of transverse colon (including hepatic and splenic flexure); BBPS score of the left colon (descending colon, sigmoid, and rectum); and number of polyps in each segment.
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Outcome measures
The two main endpoints were the overall adequate colon cleansing and high-quality cleansing of the right colon in routine clinical practice. Adequate overall colon cleansing was defined as a BBPS score of ≥6 with a BBPS score ≥2 in each segment. A BBPS score of 3 was considered high-quality cleansing in the right colon, and a score ≥8 was considered high quality for the total colon.
The main exploratory endpoints were polyp detection rates (PDRs) in the total colon and right colon, defined as the proportion of colonoscopies where at least one polyp was found and removed; ADR in the total colon and right colon, defined as the proportion of colonoscopies where at least one adenoma was found as determined by histological analysis; CIR; cecal intubation time and colonoscopy withdrawal time; and safety from recorded adverse events (AEs). The effectiveness and safety of 1L PEG + Asc in patients aged ≥65 versus <65 years were also assessed. Details of the evaluation criteria for the exploratory endpoints are provided in Table 1s.
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Statistical analysis
Descriptive statistics were used to present all quantitative and categorical variables. Mean values, standard deviations (SD), medians, and minimum and maximum values were calculated for quantitative variables. For categorical variables, the frequency and percentage were calculated and for proportion values, 95% confidence intervals (CIs) were calculated using the Wilcoxon method. The Chi-square test was used to compare outcomes in the subgroups of patients treated using overnight split versus same-day dosing, and aged ≥65 versus <65 years, but if the proportion of expected values less than 5 was higher than 20%, Fisher’s exact test was applied. Statistical Analysis Software (SAS; SAS Inc., Cary, North Carolina, United States) for Windows, version 9.4 or higher, was used to perform the analyses. Because this study was descriptive, no sample size calculations were performed. However, assuming a sample of 10,000 patients and an ineligible proportion of 10%, the expected proportions of total or right colon cleansing from 70% can be estimated with a precision of ±0.95% [22].
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Results
Patient characteristics
A total of 13169 eligible patients with mandatory data were identified across 10 centers in Spain and two centers in Portugal ([Table 1], [Fig. 1], Table 2s). Of those, 48.6% were male and 51.4% were female, and the average age of the total population was 57.0 ± 13.1 years ([Table 1]). Overall, 29.8% of patients (3929/13169) were ≥65 years of age (mean ± SD, 72.0 ± 5.6; median 71.0; range 65–95), of whom 50.6% were male. The main indications for colonoscopy were screening for colorectal cancer (41.9%), diagnostic (29.4%), follow-up (26.2%), or other (2.6%). Of those patients with available body mass index (BMI) data, 23.2% (255/1098) had a BMI >30 kg/m2. Where data were available, the following comorbidities were present in the population: hypertension 8.1% of patients (1065/13169); diabetes mellitus 3.3% (440/13169); constipation 2.9% (375/13169); inflammatory bowel disease 1.5% (203/13169); mild kidney impairment 0.8% (108/13169); and moderate kidney impairment 0.2% (25/13169) ([Table 1]). Same-day dosing was administered in 67.2% of patients (8853/13169) and overnight split dosing in 32.8% (4316/13169); no patient received 1-day dosing on the day before the colonoscopy ([Table 1]). Among the 8853 patients who underwent same-day dosing, the interval between the last dose of laxative and colonoscopy was recorded for 6649 patients: the interval was ≥5 hours in 94.3% of these patients and <5 hours in 5.7%.
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Bowel cleansing effectiveness
In the clinical setting, 1L PEG + Asc yielded high rates of overall bowel cleansing success, with 89.3% of patients (95%CI 88.7%–89.8%) achieving overall adequate colon cleansing and 53.0% (95%CI 52.1%–53.8%) achieving high-quality cleansing (BBPS score ≥8) ([Fig. 2] a). The rate of high-quality cleansing in the right colon was 49.3% (95%CI 48.4%–50.2%) ([Fig. 2] b). The mean (SD) BBPS score was 7.31 (1.84) for the total colon ([Fig. 3]), and 2.38 (0.71) for the right colon.
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Bowel cleansing effectiveness in subgroups
Colonoscopy indication
Overall adequate colon cleansing success was attained in 89.6% of patients (4937/5513) who underwent a screening colonoscopy, 89.3% (3459/3872) of those who had a diagnostic colonoscopy, and 88.8% (3061/3446) of those in the follow-up colonoscopy subgroup. Overall high-quality cleansing was achieved in 51.0% (2813/5513), 55.9% (2166/3872), and 52.0% (1791/3446) of those undergoing screening, diagnostic, and follow-up colonoscopies, respectively. High-quality cleansing of the right colon was achieved in 48.6% (2681/5513), 49.6% (1921/3872) and 49.5% (1706/3446) of those undergoing screening, diagnostic and follow-up colonoscopies, respectively.
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Dosing regimen
Adequate colon cleansing success rate was 94.7% with the overnight split-dose regimen and 86.7% with the same-day dosing regimen (P <0.0001). High-quality cleansing in the total colon was achieved in 72.0% of patients in the overnight split-dose subgroup and 43.7% of patients in the in the same-day dosing group (P <0.0001), and high-quality cleansing in the right colon was achieved in 65.4% and 41.4% of patients (P <0.0001) in the two respective groups ([Fig. 2]). Mean BBPS score was higher in the overnight split-dose regimen subgroup compared with same-day dosing in the total colon (8.02 [1.46] vs. 6.96 [1.91]; P <0.0001) and in all individual segments (P <0.0001) ([Fig. 3]).
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Age
Overall, 88.3% of patients (3468/3929) aged ≥65 years achieved overall adequate colon cleansing vs. 89.7% (8289/9240) of patients aged < 65 years (P=0.0145). Overall high-quality cleansing was achieved in 52.2% of patients (2050/3929) ≥65 years old, and in 53.3% of patients (4927/9240) <65 years (P=0.2278). The high-quality cleansing rate in the right colon was 47.1% (1850/3929) in patients aged ≥65 years vs. 50.2% (4642/9240) in patients <65 years old (P <0.0001) (Fig. 1s).
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Polyp and adenoma detection rates
At least one polyp was detected and removed in half of those undergoing a colonoscopy (PDR 49.2% [6478/13169] [95%CI 48.3%–50.1%]) ([Fig. 4] a). In the right colon, the PDR was 22.7% (95%CI 22.3%–23.7%). The mean PDR in the total colon was 1.17 (SD 2.09), and 0.36 (SD 0.89) in the right colon ([Fig. 4] b). The ADR was 42.5% (3953/9310) (95%CI 41.5%–43.5%) in the total colon and 24.3% (2054/8457) (95%CI 23.4%–25.2%) in the right colon.
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Other quality performance outcomes for colonoscopy
Colonoscopy was completed in 97.3% of patients (12809/13169) (95%CI 96.97%-97.53%). Of the 2.7% of patients in whom colonoscopy was incomplete, this was due to poor preparation in only 0.8% (Table 3s). Of 6325 patients assessed, 97.6% had a complete cecal intubation. The mean intubation time was 6.0 minutes, and the mean withdrawal time was 8.4 minutes ([Table 2]).
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Safety
In total, 2.3% of patients (95%CI 2.0%-2.5%) experienced at least one AE (n=13169). The most common AE was nausea (n=155; 1.2%), followed by vomiting (n=104; 0.8%) and abdominal pain (n=23; 0.2%) ([Table 3]). Among the 104 patients reporting vomiting, the rate of adequate bowel cleansing was 91.4%. There were no significant differences in the incidence of AEs by patient age or colonoscopy indication. However, AE incidence was higher with overnight split-dose than with same-day dosing (3.94% vs. 1.43%, respectively; P<0.0001), although the overall rates remained low in both regimens (<5% of patients).
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Discussion
This is the largest study on the use of a 1L PEG-based bowel preparation in real-world practice to date, providing robust data demonstrating that 1L PEG + Asc routinely delivers effective bowel cleansing in real-world settings across multiple centers in Spain and Portugal. Our results on overall cleansing success and right colon high-quality cleansing with both dosing regimens were similar to those seen in three Phase 3 clinical trials, despite this study being a real-world study [13] [14].
Our results confirm the effectiveness of 1L PEG + Asc previously demonstrated in smaller-scale real-world studies. Maida et al. reported that 1L PEG + Asc outperformed 2L and 4L PEG preparations. Multiple regression models showed that 1L PEG + Asc was an independent predictor of overall cleansing success, high-quality cleansing of the right colon, and tolerability [22]. Several other real-world evidence studies across Europe and the United States comparing 1L PEG + Asc with various other preparations reported improved cleansing, as well as high rates of adherence and patient satisfaction [16] [20] [21] [23]. A recent publication by Bednarska et al. comparing 1L PEG + Asc with a 2L PEG-based preparation with ascorbic acid (2L PEG-Asc) and 4L PEGs showed that all segmental BBPS scores were significantly greater for 1L PEG + Asc. Smell, taste, and total experience were better with 1L PEG + Asc than 4L PEG, and similar to 2L PEG-ASC [23]. In a prospective real-world trial of seven bowel preparations in more than 4000 patients, Gu et al. [25] reported that the best performing preparation had a mean overall BBPS score of 7.30 with an overnight split-dose regimen, compared with 8.02 in our study of over 13000 individuals. However, differences remain between the two studies, including the prospective study design and a multi-variable regression analysis performed by Gu et al. These data contribute to a growing body of evidence showing that 1L PEG + Asc delivers high effectiveness and good tolerability in both clinical trials and real-world settings.
In our dataset, adoption of the overnight split-dosing regimen was relatively low (32.8%). Differences in dosing administration were primarily due to differences in clinical practice between countries. While hospitals in Portugal tend to adopt a same-day dosing regimen because colonoscopy procedures are often carried out in the afternoon, this practice is less common in hospitals in Spain. Arieira et al. reported that overnight split dosing was associated with low adherence among patients for cultural and social reasons; consequently, same-day dosing is frequently used in certain hospitals [21].
Same-day dosing on the day of colonoscopy has been shown to be as effective as overnight split dosing [26] [27]. In the current study, high rates of overall colon cleansing success and high-quality cleansing in the right colon were attained with both the same-day and the overnight split-dosing regimens, although results were greater for the overnight split-dosing regimen. This difference may be due to the long interval (≥5 hours) between the last dose of the preparation and the start of the colonoscopy in the majority of the patients in the same-day dosing subgroup (94.3%). The European Society of Gastrointestinal Endoscopy (ESGE) guidelines recommend overnight split-dosing due to its proven superior efficacy compared with day-before dosing, and a same-day bowel preparation as an acceptable alternative to split-dosing, for patients undergoing afternoon colonoscopy [24]. However, it is also strongly recommended to start the last dose of bowel preparation within 5 hours of colonoscopy [24].
Consequently, to improve quality of bowel cleansing, it is important to consider not only the dosing regimen but also the interval between last dose of bowel preparation and the start of the colonoscopy, mainly when scheduling an afternoon procedure.
The colonoscopy completion rate in our study, another measure of quality performance, was high (97.3%). Incomplete colonoscopies were due to poor preparation in a very small proportion of cases (0.7%), even lower than the rate of 2.1% reported by Bednarska et al. (n=523) [23]. Both results represent a considerable improvement over previous reports from the USA, the UK, and Italy, which found that 17% to 25% of incomplete colonoscopies using various bowel preparations were due to poor preparation [28] [29] [30]. The CIR of 97.6% (6176/6325) exceeded the minimum and target ESGE guideline of 90% and 95%, respectively. In this study, the mean withdrawal time was 8.4 minutes for all patients: according to ESGE guidelines the minimum mean time is 6 minutes, and the target standard mean time is 10 minutes. The ADR of 42.5% (3953/9310) also surpassed the minimum ESGE target of 25%. As reported by Hassan et al. ADR is a clinically relevant measure as it is linked to future colorectal cancer disease risk and mortality rates, with patients with high-quality cleansing achieving better colorectal cancer prevention [31]. These data support the capabilities of 1L PEG + Asc to consistently deliver robust colonoscopy outcomes owing to effective cleansing. It should be noted that in this real-world study, information on complete cecal intubation was not recorded for approximately 50% of patients despite there being clear guidance on the importance of recording this quality indicator [32], suggesting a gap in documentation in real-world clinical practice, in line with the findings of a European survey which identified areas requiring quality improvement and the need to promote quality monitoring throughout the colonoscopy procedure [33]. In the current study, incidence of AEs was low (2.3%) with only 1.2% of patients reporting nausea and 0.8% reporting vomiting. Overall, incidence of AEs was consistently low across all subgroups per indication and per comorbidity. We found no difference in the occurrence of AEs in those aged over 65 compared with those under 65 years of age. In agreement with our results, previous studies have demonstrated the safety of low-volume preparations compared with traditional higher-volume preparations [34], including recent evidence from the real-world setting, which showed no differences in AEs or ADRs with 1L PEG + Asc compared with 4L PEGs [16] [22]. Together, these results show that reported AEs were substantially lower in the real world than in clinical trials, where they reached rates of up to 15% [13] [14]. This could also be explained by AEs being solicited in trials, whereas in clinical practice they are spontaneously reported by patients, so AEs perceived as less important may not be reported.
This study has several strengths. A broad cross-section of patients was captured due to the large number of participants and wide inclusion criteria, with a variety of ages and co-morbidities. Thus, it provides a representative overview of cleansing results within the general population. It included 12 centers across Spain and Portugal, representing a range of practices, procedures, and healthcare professionals. Importantly, the naturalistic, retrospective study design allowed us to determine the performance of 1L PEG + Asc in clinical practice, without the participant altering their behavior due to being observed (the Hawthorne effect).
An important limitation of our study is the lack of randomization, which potentially introduces selection bias. Nonetheless, the lack of randomization is secondary to the nature of the study, which was designed to be observational to better reflect the real-world practice. In addition, the lack of a comparator group in our study did not allow comparison of the performance of 1L PEG-Asc with other bowel preparations that may be used in clinical practice. Furthermore, due the retrospective design of the study, high rates of missing data for some endpoints were observed. Thus, our analysis focused mainly on procedure endpoints consistently collected in daily practice. Another important limitation of the current study is the difference in the data collection methodology adopted in different centers. To demonstrate clinically meaningful differences between regimens in terms of bowel preparation quality, future studies of large patient cohorts might benefit from including patient-outcome endpoints, such as the rate of post-colonoscopy colorectal cancer (i.e., missed lesions). Finally, while some statistically significant differences were observed between subgroups (i.e., dosing regimens and age), the clinical relevance of these differences is unclear and needs to be further studied.
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Conclusions
In conclusion, results from this large-scale, multicenter study confirmed the effectiveness of 1L PEG + Asc in real-world settings with regard to high rates of overall colon cleansing success, high-quality cleansing in the right colon and high PDRs across different subgroups, including challenging populations such as elderly patients. This is associated with optimization of quality indicators in colonoscopy that, despite being a retrospective study in which endoscopists did not feel monitored, is broadly in line with the standards of the ESGE. These data also showed that 1L PEG + Asc is well tolerated overall, with a low incidence of AEs.
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Conflict of Interest
S. Rodríguez and E. Pérez Arellano have received a speaker’s fee from Norgine. F. Akriche and C. Turbí Disla are employees of Norgine. All other authors have no conflict of interest.
Acknowledgement
The authors thank all the participating patients, investigators, and study personnel for their contributions to this observational study. Medical writing assistance was provided by TVF Communications and mXm Medical Communications and funded by Norgine.
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- 27 Cheng YL, Huang KW, Liao WC. et al. Same-day versus split-dose bowel preparation before colonoscopy: a meta-analysis. J Clin Gastroenterol 2018; 52: 392-400 DOI: 10.1097/MCG.0000000000000860 .
- 28 Halphen M, Tayo B, Flanagan S. et al. Pharmacodynamic and Clinical evaluation of low-volume polyethylene glycol (PEG)-based bowel cleansing solutions (ner1006) using split dosing in healthy and screening colonoscopy subjects: 655. Am J Gastroenterol 2014; 109: S189 DOI: 10.1016/j.gie.2017.07.047.
- 29 Johnson DA, Barkun AN, Cohen LB. et al. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology 2014; 147: 903-924 DOI: 10.1053/j.gastro.2014.07.002.
- 30 Radaelli F, Meucci G, Sgroi G. et al. Technical performance of colonoscopy: the key role of sedation/analgesia and other quality indicators. Am J Gastroenterol 2008; 103: 1122-1130 DOI: 10.1111/j.1572-0241.2007.01778.x. (PMID: 18445096)
- 31 Hassan C, Manning J, Álvarez González MA. et al. Improved detection of colorectal adenomas by high-quality colon cleansing. Endosc Int Open 2020; 08: E928-E937 DOI: 10.1055/s-0043-103411.
- 32 Kaminski MF, Thomas-Gibson S, Bugajski M. et al. Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative. Endoscopy 2017; 49: 378-97 DOI: 10.1055/s-0043-103411.
- 33 Spada C, Koulaouzidis A, Hassan C. et al. Colonoscopy quality across Europe: a report of the European Colonoscopy Quality Investigation (ECQI) Group. Endosc Int Open 2021; 9: E1456-E1462 DOI: 10.1055/a-1486-6729. (PMID: 34540535)
- 34 Manno M, Biancheri P, Bonura GF. et al. Safety of a novel 1L-polyethylene glycol ascorbate solution for colonoscopy cleansing (REAL Study). Dig Liver Dis 2022; 54: 1508-1512 DOI: 10.1016/j.dld.2022.04.014.
Correspondence
Publication History
Received: 11 January 2023
Accepted after revision: 23 June 2023
Article published online:
16 August 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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- 27 Cheng YL, Huang KW, Liao WC. et al. Same-day versus split-dose bowel preparation before colonoscopy: a meta-analysis. J Clin Gastroenterol 2018; 52: 392-400 DOI: 10.1097/MCG.0000000000000860 .
- 28 Halphen M, Tayo B, Flanagan S. et al. Pharmacodynamic and Clinical evaluation of low-volume polyethylene glycol (PEG)-based bowel cleansing solutions (ner1006) using split dosing in healthy and screening colonoscopy subjects: 655. Am J Gastroenterol 2014; 109: S189 DOI: 10.1016/j.gie.2017.07.047.
- 29 Johnson DA, Barkun AN, Cohen LB. et al. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology 2014; 147: 903-924 DOI: 10.1053/j.gastro.2014.07.002.
- 30 Radaelli F, Meucci G, Sgroi G. et al. Technical performance of colonoscopy: the key role of sedation/analgesia and other quality indicators. Am J Gastroenterol 2008; 103: 1122-1130 DOI: 10.1111/j.1572-0241.2007.01778.x. (PMID: 18445096)
- 31 Hassan C, Manning J, Álvarez González MA. et al. Improved detection of colorectal adenomas by high-quality colon cleansing. Endosc Int Open 2020; 08: E928-E937 DOI: 10.1055/s-0043-103411.
- 32 Kaminski MF, Thomas-Gibson S, Bugajski M. et al. Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative. Endoscopy 2017; 49: 378-97 DOI: 10.1055/s-0043-103411.
- 33 Spada C, Koulaouzidis A, Hassan C. et al. Colonoscopy quality across Europe: a report of the European Colonoscopy Quality Investigation (ECQI) Group. Endosc Int Open 2021; 9: E1456-E1462 DOI: 10.1055/a-1486-6729. (PMID: 34540535)
- 34 Manno M, Biancheri P, Bonura GF. et al. Safety of a novel 1L-polyethylene glycol ascorbate solution for colonoscopy cleansing (REAL Study). Dig Liver Dis 2022; 54: 1508-1512 DOI: 10.1016/j.dld.2022.04.014.
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