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DOI: 10.1055/a-2015-1359
Growth Hormone Signaling in Liver Diseases: Therapeutic Potentials and Controversies
Funding This work was supported by the Indiana University Health – Indiana University School of Medicine Strategic Research Initiative, the Career Scientist Award (IK6BX005226), and the VA Merit award (1I01BX003031) to H.F. from the United States Department of Veteran's Affairs, Biomedical Laboratory Research and Development Service, and NIH grants AA030107, DK108959, and DK119421 (H.F.). Portions of these studies were supported by resources at Richard L. Roudebush VA Medical Center, Indianapolis, IN. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.
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Abstract
Growth hormone (GH) and downstream insulin-like growth factor 1 (IGF1) signaling mediate growth and metabolism. GH deficiency causes short stature or dwarfism, and excess GH causes acromegaly. Although the association of GH/IGF1 signaling with liver diseases has been suggested previously, current studies are controversial and the functional roles of GH/IGF1 signaling are still undefined. GH supplementation therapy showed promising therapeutic effects in some patients, such as non-alcoholic fatty liver disease, but inhibition of GH signaling may be beneficial for other liver diseases, such as hepatocellular carcinoma. The functional roles of GH/IGF1 signaling and the effects of agonists/antagonists targeting this signaling may differ depending on the liver injury or animal models. This review summarizes current controversial studies of GH/IGF1 signaling in liver diseases and discusses therapeutic potentials of GH therapy.
Keywords
growth hormone - liver regeneration - lipid metabolism - liver fibrosis - hepatic tumorigenesisPublication History
Accepted Manuscript online:
18 January 2023
Article published online:
10 February 2023
© 2023. Thieme. All rights reserved.
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