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Int J Sports Med 2023; 44(03): 159-168
DOI: 10.1055/a-1929-0295
Review

Prescription of High-intensity Aerobic Interval Training Based on Oxygen Uptake Kinetics

Raúl Ricardo Festa
1   Laboratorio de Fisiología del Ejercicio y Metabolismo, Escuela de Kinesiología, Universidad Finis Terrae, Santiago, Chile
,
Matías Monsalves-Álvarez
2   Instituto de Ciencias de la Salud, Universidad de O’Higgins, Rancagua, Chile
,
Jorge Cancino
1   Laboratorio de Fisiología del Ejercicio y Metabolismo, Escuela de Kinesiología, Universidad Finis Terrae, Santiago, Chile
,
Sebastián Jannas-Vela 
2   Instituto de Ciencias de la Salud, Universidad de O’Higgins, Rancagua, Chile
› Author Affiliations Funding This work was supported by Fondecyt, Chile under Grant awarded to SJ-V [#11220333]
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Abstract

Endurance training results in diverse adaptations that lead to increased performance and health benefits. A commonly measured training response is the analysis of oxygen uptake kinetics, representing the demand of a determined load (speed/work) on the cardiovascular, respiratory, and metabolic systems, providing useful information for the prescription of constant load or interval-type aerobic exercise. There is evidence that during high-intensity aerobic exercise some interventions prescribe brief interval times (<1-min), which may lead to a dissociation between the load prescribed and the oxygen uptake demanded, potentially affecting training outcomes. Therefore, this review explored the time to achieve a close association between the speed/work prescribed and the oxygen uptake demanded after the onset of high-intensity aerobic exercise. The evidence assessed revealed that at least 80% of the oxygen uptake amplitude is reached when phase II of oxygen uptake kinetics is completed (1 to 2 minutes after the onset of exercise, depending on the training status). We propose that the minimum work-time during high-intensity aerobic interval training sessions should be at least 1 minute for athletes and 2 minutes for non-athletes. This suggestion could be used by coaches, physical trainers, clinicians and sports or health scientists for the prescription of high-intensity aerobic interval training.

Key words

endurance training - high-intensity aerobic exercise - oxygen uptake demanded - running - cycling


Publication History

Received: 16 March 2022

Accepted: 19 August 2022

Accepted Manuscript online:
22 August 2022

Article published online:
09 December 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Hawley J.. Adaptations of skeletal muscle to prolonged, intense endurance training. Clin Exp Pharmacol Physiol 2002; 29: 218-222
    CrossrefPubMedGoogle Scholar
  • 2 Holloszy J, Coyle E.. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol Respir Env Exerc Physiol 1984; 56: 831-838
    PubMedGoogle Scholar
  • 3 Jones A, Carter H.. The effect of endurance training on parameters of aerobic fitness. Sports Med 2000; 29: 373-386
    CrossrefPubMedGoogle Scholar
  • 4 Seiler S, Tønnessen E.. Intervals, thresholds, and long slow distance: the role of intensity and duration in endurance training. Sportscience 2009; 13: 32-53
    PubMedGoogle Scholar
  • 5 Wenger HA, Bell GJ.. The interactions of intensity, frequency and duration of exercise training in altering cardiorespiratory fitness. Sports Med 1986; 3: 346-356
    CrossrefPubMedGoogle Scholar
  • 6 Lambert MI.. Quantification of endurance training and competition loads. In: Mujika I (Ed). Endurance Training - Science and Practice: Vitoria-Gasteiz (Basque Country); 2012: 23-28
    Google Scholar
  • 7 Impellizzeri FM, Marcora SM, Coutts AJ.. Internal and external training load: 15 years on. Int J Sports Physiol Perform 2019; 14: 270-273
    CrossrefPubMedGoogle Scholar
  • 8 Jeukendrup A, Diemen A.. Heart rate monitoring during training and competition in cyclists. J Sports Sci 1998; 16: 91-99
    CrossrefPubMedGoogle Scholar
  • 9 Jones AM, Doust JH.. A 1% treadmill grade most accurately reflects the energetic cost of outdoor running. J Sports Sci 1996; 14: 321-327
    CrossrefPubMedGoogle Scholar
  • 10 Jones AM, Kirby BS, Clark IE. et al. Physiological demands of running at 2-hour marathon race pace. J Appl Physiol (1985) 2021; 130: 369-379
    CrossrefPubMedGoogle Scholar
  • 11 Halson SL.. Monitoring training load to understand fatigue in athletes. Sports Med 2014; 44: 139-147
    CrossrefPubMedGoogle Scholar
  • 12 Mujika I.. Quantification of training and competition loads in endurance sports: methods and applications. Int J Sports Physiol Perform 2017; 12: S29-S217
    CrossrefPubMedGoogle Scholar
  • 13 Poole D, Jones A.. Oxygen uptake kinetics. Compr Physiol 2012; 2: 933-996
    CrossrefPubMedGoogle Scholar
  • 14 Rossiter HB.. Exercise: Kinetic considerations for gas exchange. Compr Physiol 2011; 1: 203-244
    CrossrefPubMedGoogle Scholar
  • 15 Mezzani A, Hamm LF, Jones AM. et al. Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: A joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitat. Eur J Prev Cardiol 2013; 20: 442-467
    CrossrefPubMedGoogle Scholar
  • 16 Burnley M, Jones A.. Oxygen uptake kinetics as a determinant of sports performance. Eur J Sports Sci 2007; 7: 63-79
    CrossrefPubMedGoogle Scholar
  • 17 Wilkerson DP, Koppo K, Barstow TJ. et al. Effect of work rate on the functional „gain“ of Phase II pulmonary O2 uptake response to exercise. Respir Physiol Neurobiol 2004; 142: 211-223
    CrossrefPubMedGoogle Scholar
  • 18 Whipp B, Ward S.. Pulmonary gas exchange dynamics and the tolerance to muscular exercise: effects of fitness and training. Ann Physiol Anthr 1992; 11: 207-214
    CrossrefPubMedGoogle Scholar
  • 19 Poole D, Rossiter H, Brooks G. et al. The anaerobic threshold : 50 + years of controversy. J Physiol 2021; 3: 737-767
    CrossrefPubMedGoogle Scholar
  • 20 Beaver WL, Wasserman K, Whipp BJ.. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol (1985) 1986; 60: 2020-2027
    CrossrefPubMedGoogle Scholar
  • 21 Adami A, Pogliaghi S, De Roia G. et al. Oxygen uptake, cardiac output and muscle deoxygenation at the onset of moderate and supramaximal exercise in humans. Eur J Appl Physiol 2011; 111: 1517-1527
    CrossrefPubMedGoogle Scholar
  • 22 Barstow T, Mole P.. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J Appl Physiol (1985) 1991; 71: 2099-2106
    CrossrefPubMedGoogle Scholar
  • 23 Burnley M, Jones A, Carter H. et al. Effects of prior heavy exercise on phase II pulmonary oxygen uptake kinetics during heavy exercise. J Appl Physiol (1985) 2000; 89: 1387-1396
    CrossrefPubMedGoogle Scholar
  • 24 Carter H, Jones A, Barstow TJ. et al. Oxygen uptake kinetics in treadmill running and cycle ergometry: A comparison. J Appl Physiol (1985) 2000; 89: 899-907
    CrossrefPubMedGoogle Scholar
  • 25 Cleuziou C, Perrey S, Borrani F. et al. V̇O2 and EMG activity kinetics during moderate and severe constant work rate exercise in trained cyclists. Can J Appl Physiol 2004; 29: 758-772
    CrossrefPubMedGoogle Scholar
  • 26 Cleuziou C, Perrey S, Borrani F. et al. Dynamic responses of oxygen uptake at the onset and end of moderate and heavy exercise in trained subjects. Can J Appl Physiol 2004; 29: 32-44
    CrossrefPubMedGoogle Scholar
  • 27 Faisal A, Beavers KR, Robertson AD. et al. Prior moderate and heavy exercise accelerate oxygen uptake and cardiac output kinetics in endurance athletes. J Appl Physiol (1985) 2009; 106: 1553-1563
    CrossrefPubMedGoogle Scholar
  • 28 Koga S, Shiojiri T, Shibasaki M. et al. Kinetics of oxygen uptake during supine and upright heavy exercise. J Appl Physiol (1985) 1999; 87: 253-260
    CrossrefPubMedGoogle Scholar
  • 29 Koppo K, Bouckaert J, Jones AM.. Effects of training status and exercise intensity on phase II V̇O 2 kinetics. Med Sci Sports Exerc 2004; 36: 225-232
    CrossrefPubMedGoogle Scholar
  • 30 Perrey S, Betik A, Candau R. et al. Comparison of oxygen uptake kinetics during concentric and eccentric cycle exercise. J Appl Physiol (1985) 2001; 91: 2135-2142
    CrossrefPubMedGoogle Scholar
  • 31 Carter H, Jones AM, Barstow TJ. et al. Effect of endurance training on oxygen uptake kinetics during treadmill running. J Appl Physiol (1985) 2000; 89: 1744-1752
    CrossrefPubMedGoogle Scholar
  • 32 Carter H, Pringle JSM, Jones AM. et al. Oxygen uptake kinetics during treadmill running across exercise intensity domains. Eur J Appl Physiol 2002; 86: 347-354
    CrossrefPubMedGoogle Scholar
  • 33 Carter H, Jones AM, Maxwell NS. et al. The effect of interdian and diurnal variation on oxygen uptake kinetics during treadmill running. J Sports Sci 2002; 20: 901-909
    CrossrefPubMedGoogle Scholar
  • 34 Pringle J, Carter H, Doust J. et al. Oxygen uptake kinetics during horizontal and uphill treadmill running in humans. Eur J Appl Physiol 2002; 88: 163-169
    CrossrefPubMedGoogle Scholar
  • 35 Williams CA, Carter H, Jones AM. et al. Oxygen uptake kinetics during treadmill running in boys and men. J Appl Physiol (1985) 2001; 90: 1700-1706
    CrossrefPubMedGoogle Scholar
  • 36 Colosio AL, Caen K, Bourgois JG. et al. Bioenergetics of the VO2 slow component between exercise intensity domains. Pflugers Arch 2020; 472: 1447-1456
    CrossrefPubMedGoogle Scholar
  • 37 Jones A, Grassi B, Christensen PM. et al. Slow component of VO2 kinetics: Mechanistic bases and practical applications. Med Sci Sports Exerc 2011; 43: 2046-2062
    CrossrefPubMedGoogle Scholar
  • 38 Vanhatalo A, Poole DC, DiMenna FJ. et al. Muscle fiber recruitment and the slow component of O2 uptake: Constant work rate vs. all-out sprint exercise. Am J Physiol Regul Integr Comp Physiol 2011; 300: R700-R707
    CrossrefPubMedGoogle Scholar
  • 39 Bräuer EK, Smekal G.. VO2 steady state at and just above maximum lactate steady state intensity. Int J Sports Med 2020; 41: 574-581
    Article in Thieme ConnectPubMedGoogle Scholar
  • 40 Nixon RJ, Kranen SH, Vanhatalo A. et al. Steady-state VO2 above MLSS : evidence that critical speed better represents maximal metabolic steady state in well‑trained runners. Eur J Appl Physiol 2021; 121: 3133-3144
    CrossrefPubMedGoogle Scholar
  • 41 Poole D, Ward S, Gardner G. et al. Metabolic and respiratory profile of the upper limit for prolonged exercise in man. Ergonomics 1988; 31: 1265-1279
    CrossrefPubMedGoogle Scholar
  • 42 Bernard O, Maddio F, Ouattara S. et al. Influence of the oxygen uptake slow component on the aerobic energy cost of high-intensity submaximal treadmill running in humans. Eur J Appl Physiol Occup Physiol 1998; 78: 578-585
    CrossrefPubMedGoogle Scholar
  • 43 Hill D, Halcomb JN, Stevens EC.. Oxygen uptake kinetics during severe intensity running and cycling. Eur J Appl Physiol 2003; 89: 612-618
    CrossrefPubMedGoogle Scholar
  • 44 Jones AM, Wilkerson DP, DiMenna F. et al. Muscle metabolic responses to exercise above and below the „critical power“ assessed using 31P-MRS. Am J Physiol Regul Integr Comp Physiol 2008; 294: R585-R593
    CrossrefPubMedGoogle Scholar
  • 45 Guellich A, Seiler S.. Lactate profile changes in relation to training characteristics in junior elite cyclists. Int J Sports Physiol Perform 2010; 5: 316-327
    CrossrefPubMedGoogle Scholar
  • 46 Billat V, Lepretre P, Heugas A. et al. Training and bioenergetic characteristics in elite male and female Kenyan runners. Med Sci Sports Exerc 2003; 35: 297-304
    CrossrefPubMedGoogle Scholar
  • 47 Haugen T, Sandbakk Ø, Seiler S. et al. The training characteristics of world-class distance runners: an integration of scientific literature and results-proven practice. Sports Med Open 2022; 8: 46
    CrossrefPubMedGoogle Scholar
  • 48 Haugen T, Sandbakk Ø, Enoksen E. et al. Crossing the golden training divide: the science and practice of training world-class 800- and 1500-m runners. Sports Med 2021; 51: 1835-1854
    CrossrefPubMedGoogle Scholar
  • 49 Rozenek R, Funato K, Kubo J. et al. Physiological responses to interval training sessions at velocities associated with VO2max. J Strength Cond Res 2007; 21: 188-192
    PubMedGoogle Scholar
  • 50 Turner AP, Cathcart AJ, Parker ME. et al. Oxygen uptake and muscle desaturation kinetics during intermittent cycling. Med Sci Sports Exerc 2006; 38: 492-503
    CrossrefPubMedGoogle Scholar
  • 51 Davies MJ, Benson AP, Cannon DT. et al. Dissociating external power from intramuscular exercise intensity during intermittent bilateral knee-extension in humans. J Physiol 2017; 595: 6673-6686
    CrossrefPubMedGoogle Scholar
  • 52 Combes A, Dekerle J, Bougault V. et al. Effect of work:rest cycle duration on fluctuations during intermittent exercise. J Sports Sci 2017; 35: 7-13
    CrossrefPubMedGoogle Scholar
  • 53 Rosenblat M, Perrotta A, Thomas S.. Effect of high-intensity interval training versus sprint interval training on time-trial performance: a systematic review and meta-analysis. Sports Med 2020; 50: 1145-1161
    CrossrefPubMedGoogle Scholar
  • 54 Spriet LL, Howlett RA, Heigenhauser GJF.. An enzymatic approach to lactate production in human skeletal muscle during exercise. Med Sci Sports Exerc 2000; 32: 756-763
    CrossrefPubMedGoogle Scholar
  • 55 Hargreaves M, Spriet LL.. Skeletal muscle energy metabolism during exercise. Nat Metab 2020; 2: 817-828
    CrossrefPubMedGoogle Scholar
  • 56 Jones AM., Burnley M.. Oxygen uptake kinetics: An underappreciated determinant of exercise performance. Int J Sports Physiol Perform 2009; 4: 524-532
    CrossrefPubMedGoogle Scholar
  • 57 Di Prampero PE, Mahler PB, Giezendanner D. et al. Effects of priming exercise on V̇O2 kinetics and O2 deficit at the onset of stepping and cycling. J Appl Physiol (1985) 1989; 66: 2023-2031
    CrossrefPubMedGoogle Scholar
  • 58 Whipp BJ, Wasserman K.. Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol 1972; 33: 351-356
    CrossrefPubMedGoogle Scholar
  • 59 Wasserman K, Hansen J, Sue D. et al. Exercise testing and interpretation. In: Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications: Fifth edition. Philadelphia (US): Lippincott Williams & Wilkins; 2012: 1-8
    Google Scholar
  • 60 Whipp B, Ward S, Rossiter H.. Pulmonary O2 uptake during exercise: Conflating muscular and cardiovascular responses. Med Sci Sports Exerc 2005; 37: 1574-1585
    CrossrefPubMedGoogle Scholar
  • 61 Jones A, Poole D.. Introduction to oxygen uptake kinetics and historical development of the discipline. In: Jones Andrew M. & Poole David C., Eds. Oxygen Uptake Kinetics in Sport, Exercise and Medicine: Research and Practical Applications. London (U.K.) and New York (U.S.): Routledge by Taylor & Francis Group; 2005. pp 3-35
    Google Scholar
  • 62 Jones A, Poole D.. Oxygen uptake dynamics: From muscle to mouth - An introduction to the symposium. Med Sci Sports Exerc 2005; 37: 1542-1550
    CrossrefPubMedGoogle Scholar
  • 63 Seiler K, Kjerland G.. Quantifying training intensity distribution in elite endurance athletes: Is there evidence for an „optimal“ distribution?. Scand J Med Sci Sport 2006; 16: 49-56
    CrossrefPubMedGoogle Scholar
  • 64 Whipp BJ, Rossiter HB.. The kinetics of oxygen uptake. Physiological inferences from the parameters. In: Jones AM PD, Eds. Oxygen Uptake Kinetics in Sport, Exercise and Medicine: Research and Practical Applications. London (U.K.) and New York (U.S.): Routledge by Taylor & Francis Group; 2005: 62-94
    Google Scholar
  • 65 Caputo F, Denadai BS.. Effects of aerobic endurance training status and specificity on oxygen uptake kinetics during maximal exercise. Eur J Appl Physiol 2004; 93: 87-95
    CrossrefPubMedGoogle Scholar
  • 66 Jones A, McConnell A.. Effect of exercise modality on oxygen uptake kinetics during heavy exercise. Eur J Appl Physiol 1999; 80: 213-219
    CrossrefPubMedGoogle Scholar
  • 67 Bull AJ, Housh TJ, Johnson GO. et al. Effect of mathematical modeling on the estimation of critical power. Med Sci Sports Exerc 2000; 32: 526-530
    CrossrefPubMedGoogle Scholar
  • 68 Lucia A, Sánchez O, Carvajal A. et al. Analysis of the aerobic-anaerobic transition in elite cyclists during incremental exercise with the use of electromyography. Br J Sports Med 1999; 33: 178-185
    CrossrefPubMedGoogle Scholar
  • 69 Conde Alonso S, Gajanand T, Ramos JS. et al. The metabolic profiles of different fiber type populations under the emergence of the slow component of oxygen uptake. J Physiol Sci 2020; 70: 27
    CrossrefPubMedGoogle Scholar
  • 70 Nilsson A, Björnson E, Flockhart M. et al. Complex I is bypassed during high intensity exercise. Nat Commun 2019; 10: 5072
    CrossrefPubMedGoogle Scholar
  • 71 Willis W, Jackman M.. Mitochondrial function during heavy exercise. Med Sci Sports Exerc 1994; 26: 1347-1353
    CrossrefPubMedGoogle Scholar
  • 72 Szentesi P, Zaremba R, Van Mechelen W. et al. ATP utilization for calcium uptake and force production in different types of human skeletal muscle fibres. J Physiol 2001; 531: 393-403
    CrossrefPubMedGoogle Scholar
  • 73 Laursen P, Shing C, Jenkins D.. Temporal Aspects of the VO2 response at the power output associated with VO2peak in well trained cyclists—implications for interval training prescription. Res Q Exerc Sport 2004; 75: 423-428
    CrossrefPubMedGoogle Scholar
  • 74 Hill D, Rowell A.. Responses to exercise at the velocity associated with VO2max. Med Sci Sports Exerc 1997; 29: 113-116
    CrossrefPubMedGoogle Scholar
  • 75 Barbosa LF, Denadai BS, Greco CC.. Endurance performance during severe-intensity intermittent cycling: Effect of exercise duration and recovery type. Front Physiol 2016; 7: 602
    CrossrefPubMedGoogle Scholar
  • 76 Billat L.. Interval training for performance: A scientific and empirical practice. Special recommendations for middle- and long-distance running. Part I: Aerobic interval training. Sports Med 2001; 31: 13-31
    CrossrefPubMedGoogle Scholar
  • 77 Buchheit M, Laursen PB.. High-intensity interval training, solutions to the programming puzzle: Part I: Cardiopulmonary emphasis. Sports Med 2013; 43: 313-338
    CrossrefPubMedGoogle Scholar
  • 78 Casado A, Hanley B, Ruiz-Pérez LM.. Deliberate practice in training differentiates the best Kenyan and Spanish long-distance runners. Eur J Sport Sci 2020; 20: 887-895
    CrossrefPubMedGoogle Scholar
  • 79 Schumacher Y, Mueller P.. The 4000-m team pursuit cycling world record: Theoretical and practical aspects. Med Sci Sports Exerc 2002; 34: 1029-1036
    CrossrefPubMedGoogle Scholar
  • 80 Ito S.. High-intensity interval training for health benefits and care of cardiac diseases - The key to an efficient exercise protocol. World J Cardiol 2019; 11: 171-188
    CrossrefPubMedGoogle Scholar
  • 81 Astrand I, Astrand P, Christense E. et al. Intermittent muscular work. Acta Physiol Scand 1960; 48: 448-453
    CrossrefPubMedGoogle Scholar
  • 82 Seiler S, Sjursen J.. Effect of work duration on physiological and rating scale of perceived exertion responses during self-paced interval training. Scand J Med Sci Sports 2004; 14: 318-325
    CrossrefPubMedGoogle Scholar
  • 83 Franch J, Madsen K, Djurhuus MS. et al. Improved running economy following intensified training correlates with reduced ventilatory demands. Med Sci Sports Exerc 1998; 30: 1250-1256
    CrossrefPubMedGoogle Scholar
  • 84 Seiler S, Jøranson K, Olesen BV.. et al. Adaptations to aerobic interval training: Interactive effects of exercise intensity and total work duration. Scand J Med Sci Sports 2013; 23: 74-83
    CrossrefPubMedGoogle Scholar
  • 85 Vuorimaa T, Vasankari T, Rusko H.. Comparison of physiological strain and muscular performance of athletes during two intermittent running exercises at the velocity associated with VO2max. Int J Sports Med 2000; 21: 96-101
    Article in Thieme ConnectPubMedGoogle Scholar
  • 86 Millet GP, Candau R, Fattori P. et al. V̇O2 responses to different intermittent runs at velocity associated with V̇O2max. Can J Appl Physiol 2003; 28: 410-423
    CrossrefPubMedGoogle Scholar
  • 87 Stepto N, Hawley J, Dennis S. et al. Effects of different interval-training programs on cycling time-trial performance. Med Sci Sports Exerc 1999; 31: 736-741
    CrossrefPubMedGoogle Scholar
  • 88 Esfarjani F, Laursen PB.. Manipulating high-intensity interval training: Effects on over VO2 max, the lactate threshold and 3000 m running performance in moderately trained males. J Sci Med Sport 2007; 10: 27-35
    CrossrefPubMedGoogle Scholar
  • 89 Bacon AP, Carter RE, Ogle EA. et al. VO2max trainability and high intensity interval training in humans: a meta-analysis. PLoS One 2013; 8: e73182
    CrossrefPubMedGoogle Scholar
  • 90 Kodama S, Saito K, Tanaka S. et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. J Am Med Assoc 2009; 301: 2024-2035
    CrossrefPubMedGoogle Scholar
  • 91 Rønnestad BR, Hansen J, Nygaard H. et al. Superior performance improvements in elite cyclists following short-interval vs effort-matched long-interval training. Scand J Med Sci Sport 2020; 30: 849-857
    CrossrefPubMedGoogle Scholar
  • 92 Almquist NW, Nygaard H, Vegge G. et al. Systemic and muscular responses to effort-matched short intervals and long intervals in elite cyclists. Scand J Med Sci Sport 2020; 30: 1140-1150
    CrossrefPubMedGoogle Scholar
  • 93 Özyener F, Rossiter HB, Ward SA. et al. Influence of exercise intensity on the on- and off- transient kinetics of pulmonary oxygen uptake in humans. J Physiol 2001; 533: 891-902
    CrossrefPubMedGoogle Scholar
  • 94 Paterson DH, Whipp BJ.. Asymmetries of oxygen uptake transients at the on- and offset of heavy exercise in humans. J Physiol 1991; 443: 575-586
    CrossrefPubMedGoogle Scholar
  • 95 Scheuermann BW, Hoelting BD, Larry Noble M. et al. The slow component of O2 uptake is not accompanied by changes in muscle EMG during repeated bouts of heavy exercise in humans. J Physiol 2001; 531: 245-256
    CrossrefPubMedGoogle Scholar
  • 96 Vaccari F, Giovanelli N, Lazzer S.. High-intensity decreasing interval training (HIDIT) increases time above 90% V˙O2peak. Eur J Appl Physiol 2020; 120: 2397-2405
    CrossrefPubMedGoogle Scholar
  • 97 Stoøren O, Bratland-Sanda S, Haave M. et al. Improved VO2max and time trial performance with more high aerobic intensity interval training and reduced training volume: A case study on an elite national cyclist. J Strength Cond Res 2012; 26: 2705-2711
    CrossrefPubMedGoogle Scholar
  • 98 Smilios I, Myrkos A, Zafeiridis A. et al. The effects of recovery duration during high-intensity interval exercise on time spent at high rates of oxygen consumption, oxygen kinetics, and blood lactate. J Strength Cond Res 2018; 32: 2183-2189
    CrossrefPubMedGoogle Scholar
  • 99 Schoenmakers PPJM, Reed KE.. The effects of recovery duration on physiological and perceptual responses of trained runners during four self-paced HIIT sessions. J Sci Med Sports 2019; 22: 462-466
    CrossrefPubMedGoogle Scholar
  • 100 Seiler S, Hetlelid KJ.. The impact of rest duration on work intensity and RPE during interval training. Med Sci Sports Exerc 2005; 37: 1601-1607
    CrossrefPubMedGoogle Scholar
  • 101 Fennell CRJ, Hopker JG.. The acute physiological and perceptual effects of recovery interval intensity during cycling-based high-intensity interval training. Eur J Appl Physiol 2021; 121: 425-434
    CrossrefPubMedGoogle Scholar
  • 102 Kemi OJ, Fowler E, McGlynn K. et al. Intensity-dependence of exercise and active recovery in high-intensity interval training. J Sports Med Phys Fitness 2019; 59: 1937-1943
    PubMedGoogle Scholar
  • 103 Burke LM, Jones AM, Jeukendrup AE. et al. Contemporary nutrition strategies to optimize performance in distance runners and race walkers. Int J Sport Nutr Exerc Metab 2019; 29: 117-129
    CrossrefPubMedGoogle Scholar
  • 104 Padilla S, Mujika I, Angulo F. et al. Scientific approach to the 1-h cycling world record: A case study. J Appl Physiol (1985) 2000; 89: 1522-1527
    CrossrefPubMedGoogle Scholar
  • 105 Lucia A, Hoyos J, Chicharro JL.. Physiology of professional road cycling. Sports Med 2001; 31: 325-337
    Google Scholar
  • 106 Díaz JJ, Fernández-Ozcorta EJ, Santos-Concejero J.. The influence of pacing strategy on marathon world records. Eur J Sports Sci 2018; 18: 781-786
    CrossrefPubMedGoogle Scholar
  • 107 Tucker R, Lambert MI, Noakes TD.. An analysis of pacing strategies during men’s world-record performances in track athletics. Int J Sports Physiol Perform 2006; 1: 233-245
    CrossrefPubMedGoogle Scholar
  • 108 Jeukendrup AE, Craig NP, Hawley JA.. The bioenergetics of world class cycling. J Sci Med Sport 2000; 3: 414-433
    Google Scholar
  • 109 Costill DL.. Physiology of marathon running. JAMA 1972; 221: 1024-1029
    CrossrefPubMedGoogle Scholar
  • 110 Coyle EF.. Physiological regulation of marathon performance. Sports Med 2007; 37: 306-311
    CrossrefPubMedGoogle Scholar
  • 111 Jones AM, Vanhatalo A, Burnley M. et al. Critical power: Implications for determination of VO2max and exercise tolerance. Med Sci Sports Exerc 2010; 42: 1876-1890
    CrossrefPubMedGoogle Scholar
  • 112 Joyner MJ, Dominelli PB.. Central cardiovascular system limits to aerobic capacity. Exp Physiol 2021; 106: 2299-2303
    CrossrefPubMedGoogle Scholar
  • 113 Del Coso J, Fernández D, Abián-Vicen J. et al. Running pace decrease during a marathon is positively related to blood markers of muscle damage. PLoS One 2013; 8: e57602
    CrossrefPubMedGoogle Scholar
  • 114 Billat V, Pycke J, Vitiello D. et al. Race analysis of the world’s best female and male marathon runners. Int J Environ Res Public Health 2020; 17: 1177
    CrossrefPubMedGoogle Scholar
  • 115 Jones AM, Vanhatalo A.. The ‘critical power’ concept: applications to sports performance with a focus on intermittent high-intensity exercise. Sports Med 2017; 47: 65-78
    CrossrefPubMedGoogle Scholar
  • 116 Laukkanen J, Zaccardi F, Khan H. et al. Long-term change in cardiorespiratory fitness and all-cause mortality: a population-based follow-up study. Mayo Clin Proc 2016; 91: 1183-1188
    CrossrefPubMedGoogle Scholar
  • 117 Wen D, Utesch T, Wu J. et al. Effects of different protocols of high intensity interval training for VO2max improvements in adults: A meta-analysis of randomised controlled trials. J Sci Med Sport 2019; 22: 941-947
    CrossrefPubMedGoogle Scholar
  • 118 Hearon CM, Sarma S, Dias KA. et al. Impaired oxygen uptake kinetics in heart failure with preserved ejection fraction. Heart 2019; 105: 1552-1558
    CrossrefPubMedGoogle Scholar
  • 119 Li F, Kong Z, Zhu X. et al. High-intensity interval training elicits more enjoyment and positive affective valence than moderate-intensity training over a 12-week intervention in overweight young women. J Exerc Sci Fit 2022; 20: 249-255
    CrossrefPubMedGoogle Scholar
  • 120 Rosenblat M, Lin E, da Costa B. et al. Programming interval training to optimize time-trial performance: a systematic review and metaanalysis. Sports Med 2021; 51: 1687-1714
    CrossrefPubMedGoogle Scholar
  • 121 Goulding RP, Rossiter HB, Marwood S. et al. Bioenergetic mechanisms linkingV̇O2 kinetics and exercise tolerance. Exerc Sport Sci Rev 2021; 49: 274-283
    CrossrefPubMedGoogle Scholar
  • 122 Laursen P.B.. Laursen PB. Interval training for endurance. In: Mujika I (Ed). Endurance Training – Science and Practice. Vitoria-Gasteiz (Basque Country). 2012: 42-50
    Google Scholar
  • 123 Stepto NK, Martin DT, Fallon KE. et al. Metabolic demands of intense aerobic interval training in competitive cyclists. Med Sci Sports Exerc 2001; 33: 303-310
    CrossrefPubMedGoogle Scholar
  • 124 Caputo F, Denadai BS.. The highest intensity and the shortest duration permitting attainment of maximal oxygen uptake during cycling: effects of different methods and aerobic fitness level. Eur J Appl Physiol 2008; 103: 47-57
    CrossrefPubMedGoogle Scholar