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Horm Metab Res 2022; 54(08): 556-561
DOI: 10.1055/a-1804-9561
Original Article: Endocrine Care

Subacute Thyroiditis Following SARS-CoV-2 Vaccines: Six Cases Report and Review of the Literature

Neslihan Kurtulmus 
1   Department of Endocrinology and Metabolism, Acibadem Maslak Hospital, Istanbul, Turkey
,
Kubra Kayikci
2   Medical School, Bezmialem Vakif University, Istanbul, Turkey
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Abstract

Subacute thyroiditis (SAT) is an inflammatory disease of the thyroid that develops following viral upper respiratory tract infections. SARS-CoV-2 virus, the cause of COVID-19, binds to the Angiotensin-Converting Enzyme-2 (ACE2) molecule expressed on the target cell surface. Thyroid gland shows high levels of ACE2 expression. The cases of SARS-CoV-2-related subacute thyroiditis and Graves’ disease have been reported. It has recently been noted that vaccines for SARS-CoV-2 also induce autoimmune and inflammatory reactions. We present six (4 male, 2 female) cases of SAT that developed after mRNA and inactivated SARS-CoV-2 vaccines. And we have reviewed the literature. SAT was seen in 5 patients after mRNA vaccine, in one after inactivated vaccine. Their clinic and laboratory findings suggested to SAT. They were treated with nonsteroid anti-inflamatory drugs and/or methylprednisolone.They recovered within few weeks. Out patients did not have permanent hypothyroidism after SAT. The history of SARS-CoV-2 vaccination should be questioned in patients with subacute thyroiditis in pandemic days.

Keywords

thyroiditis - thyroid - subacute thyroiditis - SARS-CoV-2 vaccines


Publikationsverlauf

Eingereicht: 06. Februar 2022

Angenommen: 22. März 2022

Accepted Manuscript online:
22. März 2022

Artikel online veröffentlicht:
11. Mai 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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