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Synthesis 2022; 54(05): 1329-1338
DOI: 10.1055/a-1672-5707
DOI: 10.1055/a-1672-5707
paper
Enantioselective Construction of Multi-Nitrogen-Containing Spirocycles: Asymmetric [3+2] Annulation of 4-Isothiocyanatopyrazolones with Azodicarboxylates
We thank the Fundamental Research Funds for the Central Universities (No. DUT21LAB134) for support of this work.
Abstract
The 4-isothiocyanatopyrazolones were exploited as a class of efficient synthons for the construction of triazoline derivatives via asymmetric [3+2] annulation with azodicarboxylates, providing a wide range of structurally diverse multi-nitrogen-containing spirocycles in excellent yields (up to 97%) with excellent enantioselectivities (up to 97% ee).
Key words
asymmetric catalysis - isothiocyanatopyrazolones - triazolines - annulation - enantioselectivitySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1672-5707.
- Supporting Information
Publication History
Received: 11 August 2021
Accepted after revision: 19 October 2021
Accepted Manuscript online:
19 October 2021
Article published online:
29 November 2021
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For selected examples, see:
For selected examples of spiroprazolones, see: