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TumorDiagnostik & Therapie 2021; 42(08): 599-608
DOI: 10.1055/a-1593-7868
Thieme Onkologie aktuell

Chirurgie bei gutartigen soliden Lebertumoren

Maximilian Stanley Jusufi
  Asklepios Campus Hamburg, Medizinische Fakultät der Semmelweis Universität, Hamburg, Germany
,
Victoria Susanne Antonia Habbel
  Asklepios Campus Hamburg, Medizinische Fakultät der Semmelweis Universität, Hamburg, Germany
,
Karl J. Oldhafer
  Asklepios Campus Hamburg, Medizinische Fakultät der Semmelweis Universität, Hamburg, Germany
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Zusammenfassung

Diese Übersicht konzentriert sich auf die 3 häufigsten gutartigen Lebertumoren – hepatische Hämangiome, fokale noduläre Hyperplasien und hepatozelluläre Adenome – und bietet einen Überblick über die klinischen Präsentationen, das diagnostische Vorgehen, das konservative Management sowie die interventionelle und chirurgische Behandlung.



Publikationsverlauf

Artikel online veröffentlicht:
04. Oktober 2021

© 2021. Thieme. All rights reserved.

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  • Literatur

  • 1 de Knegt RJ, Potthoff A, Wirth T. Management benigner Lebertumoren. Internist 2020; 61: 140-146
    CrossrefPubMedSuche in Google Scholar
  • 2 European Association for the Study of the Liver. EASL Clinical Practice Guidelines on the management of benign liver tumours. J Hepatol 2016; 65: 386-398
    CrossrefPubMedSuche in Google Scholar
  • 3 Marrero JA, Ahn J, Rajender Reddy K. et al ACG clinical guideline: the diagnosis and management of focal liver lesions. Am J Gastroenterol 2014; 109: 1328-1347 ; quiz 1348.
    CrossrefPubMedSuche in Google Scholar
  • 4 Buetow PC, Pantongrag-Brown L, Buck JL. et al. Focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Radiographics 1996; 16: 369-388
    CrossrefPubMedSuche in Google Scholar
  • 5 Vilgrain V, Flejou JF, Arrive L. et al. Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients. Radiology 1992; 184: 699-703
    CrossrefPubMedSuche in Google Scholar
  • 6 Brancatelli G, Federle MP, Grazioli L. et al. Focal nodular hyperplasia: CT findings with emphasis on multiphasic helical CT in 78 patients. Radiology 2001; 219: 61-68
    CrossrefPubMedSuche in Google Scholar
  • 7 Dietrich CF, Schuessler G, Trojan J. et al. Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrastenhanced ultrasound. Br J Radiol 2005; 78: 704-707
    CrossrefPubMedSuche in Google Scholar
  • 8 Kim MJ, Lim HK, Kim SH. et al. Evaluation of hepatic focal nodular hyperplasia with contrast-enhanced gray scale harmonic sonography: initial experience. J Ultrasound Med 2004; 23: 297-305
    CrossrefPubMedSuche in Google Scholar
  • 9 Stark DD, Felder RC, Wittenberg J. et al. Magnetic resonance imaging of cavernous hemangioma of the liver: tissue-specific characterization. Am J Roentgenol 1985; 145: 213-222
    CrossrefPubMedSuche in Google Scholar
  • 10 Kehagias D, Moulopoulos L, Antoniou A. et al. Focal nodular hyperplasia: imaging findings. Eur Radiol 2001; 11: 202-212
    CrossrefPubMedSuche in Google Scholar
  • 11 Mortele KJ, Praet M, Van Vlierberghe H. et al. CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Am J Roentgenol 2000; 175: 687-692
    CrossrefPubMedSuche in Google Scholar
  • 12 Laumonier H, Bioulac-Sage P, Laurent C. et al. Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology 2008; 48: 808-818
    CrossrefPubMedSuche in Google Scholar
  • 13 Ronot M, Bahrami S, Calderaro J. et al. Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology 2011; 53: 1182-1191
    CrossrefPubMedSuche in Google Scholar
  • 14 Toro A, Mahfouz AE, Ardiri A. et al. What is changing in indications and treatment of hepatic hemangiomas. A review. Ann Hepatol 2014; 13: 327-339
    CrossrefPubMedSuche in Google Scholar
  • 15 Glinkova V, Shevah O, Boaz M. et al. Hepatic haemangiomas: possible association with female sex hormones. Gut 2004; 53: 1352-1355
    CrossrefPubMedSuche in Google Scholar
  • 16 Ozakyol A, Kebapci M. Enhanced growth of hepatic hemangiomatosis in two adults after postmenopausal estrogen replacement therapy. Tohoku J Exp Med 2006; 210: 257-261
    CrossrefPubMedSuche in Google Scholar
  • 17 Donati M, Stavrou GA, Donati A. et al. The risk of spontaneous rupture of liver hemangiomas: a critical review of the literature. J Hepatobiliary Pancreat Sci 2011; 18: 797-805
    CrossrefPubMedSuche in Google Scholar
  • 18 Kasabach HH, Merritt KK. Capillary hemangioma with extensive purpura: report of a case. Am J Dis Child 1940; 59: 1063-1070
    CrossrefPubMedSuche in Google Scholar
  • 19 Srivastava DN, Gandhi D, Seith A. et al. Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study. Abdom Imag 2001; 26: 510-514
    CrossrefPubMedSuche in Google Scholar
  • 20 Furumaya A, van Rosmalen BV, Takkenberg RB. et al. Transarterial (Chemo-)Embolization and Lipiodolization for Hepatic Haemangioma. Cardiovasc Intervent Radiol 2019; 42: 800-811
    CrossrefPubMedSuche in Google Scholar
  • 21 Hoffmann K, Schemmer P. Benigne solide Tumoren der Leber. Allgemein- und Viszeralchirurgie up2date 2011; 5: 135-146
    Thieme ConnectPubMedSuche in Google Scholar
  • 22 Rubin RA, Mitchell DG. Evaluation of the solid hepatic mass. Med Clin North Am 1996; 80: 907-928
    CrossrefPubMedSuche in Google Scholar
  • 23 Sempoux C, Paradis V, Komuta M. et al. Hepatocellular nodules expressing markers of hepatocellular adenomas in Budd-Chiari syndrome and other rare hepatic vascular disorders. J Hepatol 2015; 63: 1173-1180
    CrossrefPubMedSuche in Google Scholar
  • 24 Bioulac-Sage P, Cubel G, Balabaud C. et al. Revisiting the pathology of resected benign hepatocellular nodules using new immunohistochemical markers. Sem Liver Dis 2011; 31: 91-103
    Thieme ConnectPubMedSuche in Google Scholar
  • 25 Roche V, Pigneur F, Tselikas L. et al. Differentiation of focal nodular hyperplasia from hepatocellular adenomas with low-mechanical-index contrast-enhanced sonography (CEUS): effect of size on diagnostic confidence. Eur Radiol 2015; 25: 186-195
    CrossrefPubMedSuche in Google Scholar
  • 26 Bertin C, Egels S, Wagner M. et al. Contrast-enhanced ultrasound of focal nodular hyperplasia: a matter of size. Eur Radiol 2014; 24: 2561-2571
    CrossrefPubMedSuche in Google Scholar
  • 27 Ramirez-Fuentes C, Marti-Bonmati L, Torregrosa A. et al. Variations in the size of focal nodular hyperplasia on magnetic resonance imaging. Radiologia 2013; 55: 499-504
    CrossrefPubMedSuche in Google Scholar
  • 28 Rifai K, Mix H, Krusche S. et al. No evidence of substantial growth progression or complications of large focal nodular hyperplasia during pregnancy. Scand J Gastroenterol 2013; 48: 88-92
    CrossrefPubMedSuche in Google Scholar
  • 29 Baum JK, Bookstein JJ, Holtz F. et al. Possible association between benign hepatomas and oral contraceptives. Lancet 1973; 2: 926-929
    CrossrefPubMedSuche in Google Scholar
  • 30 Ribeiro A, Burgart LJ, Nagorney DM. et al. Management of liver adenomatosis: results with a conservative surgical approach. Liver Transplant Surg 1998; 4: 388-398
    CrossrefPubMedSuche in Google Scholar
  • 31 Rooks JB, Ory HW, Ishak KG. et al. Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA 1979; 242: 644-648
    CrossrefPubMedSuche in Google Scholar
  • 32 Steinbrecher UP, Lisbona R, Huang SN. et al. Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives. Digest Dis Sci 1981; 26: 1045-1050
    CrossrefPubMedSuche in Google Scholar
  • 33 Martin NM, Abu Dayyeh BK, Chung RT. Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage. World J Gastroenterol 2008; 14: 4573-4575
    CrossrefPubMedSuche in Google Scholar
  • 34 Bunchorntavakul C, Bahirwani R, Drazek D. et al. Clinical features and natural history of hepatocellular adenomas: the impact of obesity. Aliment Pharmacol Ther 2011; 34: 664-674
    CrossrefPubMedSuche in Google Scholar
  • 35 Nault JC, Paradis V, Cherqui D. et al. Molecular classification of hepatocellular adenoma in clinical practice. J Hepatol 2017; 67: 1074-1083
    CrossrefPubMedSuche in Google Scholar
  • 36 Dokmak S, Paradis V, Vilgrain V. et al. A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology 2009; 137: 1698-1705
    CrossrefPubMedSuche in Google Scholar
  • 37 Pilati C, Letouze E, Nault JC. et al. Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. Cancer Cell 2014; 25: 428-441
    CrossrefPubMedSuche in Google Scholar
  • 38 Zheng J, Sadot E, Vigidal JA. et al. Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. PLoS One 2018; 13: e0200776
    CrossrefPubMedSuche in Google Scholar
  • 39 Bajenaru N, Balaban V, Savulescu F. et al. Hepatic hemangioma-review. J Med Life 2015; 8 Spec Issue: 4-11
    PubMedSuche in Google Scholar
  • 40 Weimann A, Ringe B, Klempnauer J. et al Benign liver tumors: differential diagnosis and indications for surgery. World J Surg 1997; 21: 983-990 ; discussion 990-981.
    CrossrefPubMedSuche in Google Scholar
  • 41 Vogl TJ, Own A, Hammerstingl R. et al. Transarterial embolization as a therapeutic option for focal nodular hyperplasia in four patients. Eur Radiol 2006; 16: 670-675
    CrossrefPubMedSuche in Google Scholar
  • 42 van Rosmalen BV, de Graeff JJ, van der Poel MJ. et al. Impact of open and minimally invasive resection of symptomatic solid benign liver tumours on symptoms and quality of life: a systematic review. HPB (Oxford) 2019; 21: 1119-1130
    CrossrefPubMedSuche in Google Scholar
  • 43 Agrawal S, Agarwal S, Arnason T. et al. Management of Hepatocellular Adenoma: Recent Advances. Clin Gastroenterol Hepatol 2015; 13: 1221-1230
    CrossrefPubMedSuche in Google Scholar
  • 44 Di Sandro S, Slim AO, Lauterio A. et al. Liver adenomatosis: a rare indication for living donor liver transplantation. Transplant Proc 2009; 41: 1375-1377
    CrossrefPubMedSuche in Google Scholar
  • 45 Chiche L, David A, Adam R. et al. Liver transplantation for adenomatosis: European experience. Liver Transplant 2016; 22: 516-526
    CrossrefPubMedSuche in Google Scholar
  • 46 Prodromidou A, Machairas N, Garoufalia Z. et al. Liver Transplantation for giant hepatic hemangioma: a systematic review. Transplant Proc 2019; 51: 440-442
    CrossrefPubMedSuche in Google Scholar