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Exp Clin Endocrinol Diabetes 2021; 129(07): 535-541
DOI: 10.1055/a-0929-6072
Article

Circulating CTRP6 Levels are Increased in Overweight or Obese Chinese Individuals and Associated with Insulin Resistance Parameters: A Pilot Study

Xin Liao‡
1   Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China
,
Sha Liu‡
1   Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China
,
Xuejiao Tang‡
2   Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
,
Dan Yang
1   Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China
,
Hua Liu
3   Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA
,
Lin Gao
1   Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China
,
Gangyi Yang
1   Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China
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Abstract

Aims CTRP6, a newly discovered adipokine, has been found to be a regulator for energy homeostasis. However, the association between circulating CTRP6 and obesity in humans is still unclear.

Methods 256 individuals, including 185 overweight/obese (OW/OB) and 71 normal weight adults, were recruited for this study. Circulating concentrations of CTRP6 and adiponectin (Adipoq) were examined by ELISA.

Results Serum CTRP6 levels in obese individuals were significantly increased compared with those in healthy individuals (506.1±134.9 vs.363.3±80.5 ng/mL, P<0.01). Conversely, serum Adipoq concentrations in OW/OB individuals were markedly decreased compared with healthy controls [20.8 (12.1–29.3) vs. 14.1 ( 8.61–17.7) ; P<0.01]. Correlation analysis revealed that there was a positive relationship between circulating CTRP6 and age, BMI, Fat%, LDL-C, TG, WHR, TC, FBG, FIns, HOMA-IR and HbA1c, but there was an inverse correlation with Adipoq and HDL-C. Logistic regression analysis revealed that high serum CTRP6 levels are markedly associated with OW/OB. Finally, ROC curve analysis showed that the cut-off value for serum CTRP6 for prediction of IR is 518 ng/mL.

Conclusions CTRP6 may be a marker related to OW/OB.

Key words

Adipokine - CTRP-6 - overweight/obesity - Insulin resistance

Supplementary Material



Publication History

Received: 08 January 2019
Received: 04 April 2019

Accepted: 21 May 2019

Article published online:
14 August 2019

© 2019. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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