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Exp Clin Endocrinol Diabetes 2020; 128(03): 152-157
DOI: 10.1055/a-0899-5210
Article
© Georg Thieme Verlag KG Stuttgart · New York

CTRP3 is Significantly Decreased in Patients with Primary Hyperparathyroidism and Closely Related with Osteoporosis

Derya Demirtas 
1   Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey
,
Fettah Acıbucu 
2   Department of Internal Medicine, Endocrinology Division, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey
,
Filiz Alkan Baylan 
3   Department of Biochemistry, University of Sutcu Imam- Kahramanmaras, Turkey
,
Erdinc Gulumsek 
1   Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey
,
Tayyibe Saler 
1   Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey
› Author Affiliations
Further Information

Publication History

received 29 March 2019
revised 17 April 2019

accepted 24 April 2019

Publication Date:
22 May 2019 (online)

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Abstract

Background Adipokines derived from adipocytes are one of the important factors that act as circulating regulators of bone metabolism. Complement C1q/tumor necrosis factor-related protein-3 (CTRP3), a paralog of adiponectin, is are member of the CTRP superfamily. The aim of this study was to investigate the role of serum CTRP3 in the development of osteoporosis in patients with primary hyperparathyroidism.

Methods This study included 53 patients with diagnosed primary hyperparathyroidism and 30 healthy controls. Laboratory tests for the diagnosis of primary hyperparathyroidism and serum levels of CTRP3 measured for all patients. Bone mineral density was obtained on lumbar spine 1 and 4 by dual energy X-ray absorptiometry.

Results Serum CTRP3 levels were lower in patients with primary hyperparathyroidism than in the control group (p<0.001). In addition, primary hyperparathyroidism patients are were divided into two groups as, with and without osteoporosis; the levels of CTRP3 were lower in patients with osteoporosis than in patients without osteoporosis (p=0.004). In logistic regression analysis, only CTRP3 levels independently determined the patients to be osteoporosis (p<0.05). According to this analysis, decreased CTRP3 (per 1 ng/mL) levels were found to increase the risk of patients for osteoporosis by 6.9%. When the CTRP3 cut-off values were taken as 30 ng/mL, it determined osteoporosis with 76.4% sensitivity and 73.2% specificity. CTRP3 and urine calcium levels were independently associated with T score in dual energy X-ray absorptiometry.

Conclusions CTRP3 levels were significantly decreased in patients with primary hyperparathyroidism, and it is also related to osteoporosis.

Key words

adiponectin - bone mineral density - adipokine - osteopenia - dual energy X-ray absorptiometry
 

  • References

  • 1 Lumachi F, Camozzi V, Ermani M. et al. Lumbar spine bone mineral density changes in patients with primary hyperparathyroidism according to age and gender. Ann NY Acad Sci 2007; 1117: 362-366
    CrossrefPubMedGoogle Scholar
  • 2 Imanishi Y. Secondary osteoporosis. Secondary osteoporosis by primary hyperparathyroidism. Clin Calcium 2018; 28: 1627-1634
    PubMedGoogle Scholar
  • 3 Sitges-Serra A, García L, Prieto R. et al. Effect of parathyroidectomy for primary hyperparathyroidism on bone mineral density in postmenopausal women. Br J Surg 2010; 97: 1013-1019
    CrossrefPubMedGoogle Scholar
  • 4 Poulos SP, Hausman DB, Hausman GJ. The development and endocrine functions of adipose tissue. Mol Cell Endocrinol 2010; 323 pp 20-34
    CrossrefPubMedGoogle Scholar
  • 5 Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Current Biology 1998; 8: 335-340
    CrossrefPubMedGoogle Scholar
  • 6 Wong GW, Wang J, Hug C. et al. A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci USA 2004; 101: 10302-10307
    CrossrefPubMedGoogle Scholar
  • 7 Ghaib R, Waters P, Roumenina LT. et al. C1q and its growing family Immunobiology. 2007; 212: 253-266
    PubMedGoogle Scholar
  • 8 Li Y, Wright GL, Peterson JM. C1q/TNF-Related Protein 3 (CTRP3) Function and Regulation. Compr Physiol 2017; 7: 863-878
    PubMedGoogle Scholar
  • 9 Liu Y, Song CY, Wu SS. et al. Novel adipokines and bone metabolism. Int J Endocrinol 2013; 2013: 895045
    PubMedGoogle Scholar
  • 10 Maeda T, Jikko A, Abe M. et al. Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes. J Cell Physiol 2006; 206: 537-544
    CrossrefPubMedGoogle Scholar
  • 11 Yokohama-Tamaki T, Maeda T, Tanaka TS. et al. Functional analysis of CTRP3/cartducin in Meckel’s cartilage and developing condylar cartilage in the fetal mouse mandible. J Anat 218: 517-533
    PubMedGoogle Scholar
  • 12 Kim JY, Min JY, Baek JM. et al. CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. Bone 2015; 79: 242-251
    CrossrefPubMedGoogle Scholar
  • 13 Karsenty G, Wagner EF, Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development, Dev Cell. 2002; Apr 2: 389-406
    PubMedGoogle Scholar
  • 14 Xu ZH, Zhang X, Xie H. et al. Serum CTRP3 level is associated with osteoporosis in postmenopausal women. Exp Clin Endocrinol Diabetes 2018; Oct 126: 559-563
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Bilezikian JP, Brandi ML, Eastell R. et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the fourth international workshop. J Clin Endocrinol Metab 2014; Oct 99: 3561-3569
    CrossrefPubMedGoogle Scholar
  • 16 Bushinsky DA, Monk RD. Electrolyte quintet: Calcium. Lancet 1998; 352: 306-311
    CrossrefPubMedGoogle Scholar
  • 17 Li X, Jiang L, Yang M. et al. CTRP3 modulates the expression and secretion of adipokines in 3T3-L1 adipocytes. Endocr J 2014; 61: 1153-116
    CrossrefPubMedGoogle Scholar
  • 18 Kim JY, Min JY, Baek JM. et al. CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. Bone 2015; 79: 242-251
    CrossrefPubMedGoogle Scholar
  • 19 Akiyama H, Furukawa S, Wakisaka S. et al. Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways. FEBS J 2006; 273: 2257-2263
    CrossrefPubMedGoogle Scholar
  • 20 Murayama MA, Kakuta S, Maruhashi T. et al. CTRP3 plays an important role in the development of collagen-induced arthritis in mice. Biochem Biophys Res Commun 2014; 443: 42-48
    CrossrefPubMedGoogle Scholar
  • 21 Noda S, Onoda N, Ohira M. Secondary osteoporosis. Surgical treatment for patients with secondary osteoporosis. Clin Calcium 2018; 28: 1671-1677
    PubMedGoogle Scholar
  • 22 Mendoza-Moreno F, Díez-Alonso M, Ovejero-Merino E. et al. Analysis of the increase in bone mineral density after surgical treatment of primary hyperparathyroidism. J Clin Densitom 2018; Nov 9. pii S1094-S6950 30189-30186
    PubMedGoogle Scholar
  • 23 Peterson JM, Wei Z, Wong GW. C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem 2010; 285: 39691-39701
    CrossrefPubMedGoogle Scholar
  • 24 Peterson JM, Seldin MM, Wei Z. et al. CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol 2013; 305: G214-G224
    CrossrefPubMedGoogle Scholar
  • 25 Yoo HJ, Hwang SY, Hong HC. et al. Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. PLoS One 2013; 8: e55744
    CrossrefPubMedGoogle Scholar
  • 26 Sumbul HE, Koc AS. The abdominal aortic intima-media thickness increases in patients with primary hyperparathyroidism. Exp Clin Endocrinol Diabetes 2019; 127: 387-395 10.1055/a-0664-7820
    Article in Thieme ConnectPubMedGoogle Scholar