Consider Role of Glutamatergic Habenula-projecting Globus Pallidus in OCD

Abstract

Recently, in a review article in this journal, Vlček and colleagues described the putative role played by the glutamatergic system in obsessive-compulsive disorder (OCD) and how this might explain the effects of certain treatments. They describe a neuroanatomical model, which includes a specific role of the amygdala-hippocampus complex (AHC) and would complete the classic cortico-striatal-thalamo-cortical (CSTC) mechanism of OCD. The role of the AHC can perhaps be better understood when considering its ancient relationship to the rest of the forebrain of mammals. This leads to distinguishing between primary (lamprey-like), secondary (amphibian-like) and tertiary (mammal-like) parts of the forebrain including amygdaloid, ventral extrapyramidal and dorsal extrapyramidal systems, respectively. A specific role in OCD may be played by the habenula-projecting part of the pallidum, which evaluated the result of behaviour in human’s earliest vertebrate ancestors. The addition of these primary relationship to the authors’ description could be fruitful when planning the future research, as suggested by them.

Key words

habenula - amygdala - CSTC circuitry - OCD - habenula-projecting Globus pallidus

• References

• 1 Vlček P, Polak J, Brunovsky M. et al. Role of glutamatergic system in obsessive-compulsive disorder with possible therapeutic implications. Pharmacopsychiatry 2018; 51: 229-242
• 2 Loonen AJM, Ivanova SA. Circuits regulating pleasure and happiness: The evolution of reward-seeking and misery-fleeing behavioral mechanisms in vertebrates. Front Neurosci 2015; 9: 394
• 3 Loonen AJM, Ivanova SA. Circuits regulating pleasure and happiness: the evolution of the amygdalar-hippocampal-habenular connectivity in vertebrates. Front Neurosci 2016; 22: 539
• 4 Loonen AJ, Ivanova SA. The evolutionary old forebrain as site of action to develop new psychotropic drugs. J Psychopharmacol 2018; 32: 1277-1285
• 5 Loonen AJM, Ivanova SA. Circuits regulating pleasure and happiness in major depression. Med Hypotheses 2016; 87: 14-21
• 6 Heilbronner SR, Rodriguez-Romaguera J, Quirk GJ. et al. Circuit-based corticostriatal homologies between rat and primate. Biol Psychiatry 2016; 80: 509-521
• 7 Stephenson-Jones M, Kardamakis AA, Robertson B. et al. Independent circuits in the basal ganglia for the evaluation and selection of actions. Proc Natl Acad Sci USA 2013; 110: E3670-E3679
• 8 Stephenson-Jones M, Yu K, Ahrens S. et al. A basal ganglia circuit for evaluating action outcomes. Nature 2016; 539: 289-293
• 9 Batalla A, Homberg JR, Lipina TV. et al. The role of the habenula in the transition from reward to misery in substance use and mood disorders. Neurosci Biobehav Rev 2017; 80: 276-285
• 10 Cano M, Alonso P, Martinez-Zalacain I. et al. Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder. Psychol Med 2018; 48: 919-928