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Exp Clin Endocrinol Diabetes 2020; 128(01): 38-42
DOI: 10.1055/a-0794-6135
Article
© Georg Thieme Verlag KG Stuttgart · New York

Dual Infection with Hepatitis B Virus and Hepatitis C Virus Correlated with Type 2 Diabetes Mellitus

Ping-Yi Lin
1   Transplant Medicine & Surgery Research Centre, Changhua Christian Hospital, Changhua, Taiwan
2   Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
,
Shu-Chu Chen
3   Public Health Bureau of Miaoli County Government, Miaoli City, Miaoli County, Taiwan
4   Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 413, Taiwan
,
Tsai-Chang Lo
3   Public Health Bureau of Miaoli County Government, Miaoli City, Miaoli County, Taiwan
,
Hsien-Wen Kuo
5   Institute of Environmental and Occupational Health Sciences, National Yang-Ming University, Taipei, Taiwan
6   School of Public Health, National Defense Medical Center, Taipei, Taiwan
› Author Affiliations
Further Information

Publication History

received06 September 2018
revised11 October 2018

accepted 09 November 2018

Publication Date:
17 January 2019 (online)

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Abstract

Background Conflicting data exist regarding the relationship between dual infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) with type 2 diabetes mellitus (T2DM). We assessed dual infection of HBV and HCV with the levels of blood glucose and development of DM.

Methods A total of 9621 participants in a community-based study were enrolled from 18 towns in Maoli county of Taiwan. Blood samples were collected and tested for hepatitis B surface antigen (HBsAg) and antibodies (HBsAb), antibodies against hepatitis C virus (anti-HCV) and fasting plasma glucose. DM was defined as fasting plasma glucose≥126 mg per 100 ml.

Results Only 0.7% of total participants had HBV/HCV coinfection. The prevalence of HBV and HCV monoinfection were 9.9  and 5.7%, respectively. Adjusted blood glucose levels and development risk of T2DM (odds ratio [OR], 2.55; p<0.001) were significantly high among HBV/HCV coinfection group using multivariate linear regression adjusted for age, gender, education, race and BMI. Furthermore, using multivariate logistic regression models adjusted for covariates, HCV mono-and HBV/ HCV coinfection significantly increased on blood glucose levels.

Conclusions Our study shows HBV/HCV coinfection was significantly correlated with blood glucose levels. A significant proportion (28%) of participants with HBV/HCV coinfection developed T2DM. Although the precise mechanisms of dual positive infection of HBV and HCV are unclear, there is increasing evidence that dual infection of HCV and HBV is strongly associated with the development of T2DM.

Key words

dual infection - hepatitis B virus - hepatitis C virus - type 2 diabetes mellitus
 

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