Exp Clin Endocrinol Diabetes 2020; 128(12): 777-787
DOI: 10.1055/a-0767-6361
Article

Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey

Dirk Müller-Wieland
1   Department of Medicine I, University Hospital Aachen, Aachen, Germany
,
Christiane Altenburg
2   Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Heiko Becher
3   Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Janine Burchard
4   Asklepios Medical School Campus Hamburg, Semmelweis University, Hamburg, Germany
,
Anett Frisch
4   Asklepios Medical School Campus Hamburg, Semmelweis University, Hamburg, Germany
,
Jan Gebhard
5   Aeromedical Center Lufthansa, Hamburg, Germany
,
Jutta Haas
4   Asklepios Medical School Campus Hamburg, Semmelweis University, Hamburg, Germany
,
Volker Harth
6   Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Jörg Heeren
7   Department of Biochjemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Johannes Hengelbrock
3   Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Maximilian von Karais
5   Aeromedical Center Lufthansa, Hamburg, Germany
,
Birgit Knebel
8   Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Düsseldorf, Leibniz Center for Diabetes Research, Düsseldorf, Germany
,
Jörg Kotzka
8   Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Düsseldorf, Leibniz Center for Diabetes Research, Düsseldorf, Germany
,
Bernd Löwe
9   Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Nikolaus Marx
1   Department of Medicine I, University Hospital Aachen, Aachen, Germany
,
Hans Pinnschmidt
3   Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Alexandra Preisser
6   Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Matthias Rose
10   Department of Psychosomatic Medicine, Charite University Medical Center, Berlin, Germany
,
Barbara Sawitzky-Rose
11   Diabetes Center Berlin Rose, Berlin, Germany
,
Ludger Scheja
7   Department of Biochjemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Claudia Terschüren
6   Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Monika Töller
12   Department of Endocrinology, Diabetology and Rheeumatology, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany
,
Eik Vettorazzi
3   Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Karl Wegscheider
3   Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
› Author Affiliations

Abstract

The Lufthansa Prevention Study (LUPS) study is a prospective observation of a healthy worker cohort to identify early changes in metabolism leading to the Metabolic Syndrome (MetS) and to analyze their relation to behavioral factors like nutrition, physical activity, psychological status, and to underlying genetic conditions. The LUPS study recruited a sample of 1.962 non-diabetic healthy adults between 25–60 years, employed at a flight base of Lufthansa Technik GmbH in Hamburg, Germany. Baseline assessments included anthropometric measures, blood and urine samples and medical history. Psychosocial variables, dietary habits and life-style risk factors were assessed via self-reported questionnaires.

In this report we describe the study design and present baseline parameters including the prevalence of the MetS using different classification criteria. The MetS was present in 20% of male and 12% of female subjects according to the ‘Harmonizing the metabolic syndrome’ definition. The prevalence varies between 2.6% in male and 2.3% in female subjects up to 48% in male and 41% in female subjects according to different classification criteria of MetS.

In conclusion, this first cross-sectional view on the LUPS data confirms the expectation that this cohort is rather healthy and thus provides the opportunity to analyze early changes associated with the development of the MetS. The LUPS study is registered as a clinical trial NCT01313156.



Publication History

Received: 06 August 2018
Received: 16 October 2018

Accepted: 22 October 2018

Article published online:
26 November 2018

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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