Synfacts

Rubrik: Flow Chemistry

Zurück zu Rubrikenliste

Ausgabe 05/2024

Synthesis of Pentafluorosulfanylpyrazoles in Flow
All PDFs of this category

Ausgabe 04/2024

Asymmetric Rh-Catalyzed Reductive Enyne Cyclization Using a Continuous-Flow Setup
Development and Exploitation of a New Flow Reactor for Electrophotocatalysis (EPC)
Flow Chemistry Enables Safe, Kilogram-Scale Synthesis of 2-Hydroxypyridine-N-Oxide (HOPO)
All PDFs of this category

Ausgabe 03/2024

Continuous-Flow Heterogeneous Rhodium-Catalyzed Asymmetric Hydroacylations
All PDFs of this category

Ausgabe 02/2024

Simmons–Smith Cyclopropanation in Flow
Continuous-Flow Chemoenzymatic Enantioselective Synthesis of Chiral α-Fluoromethyl Amines
All PDFs of this category

Ausgabe 01/2024

Rapid Access to Acyl Hydrazides in Continuous Flow
All PDFs of this category

Ausgabe 12/2023

Investigating Ozone Solubility in Organic Solvents for Use in Flow Ozonolysis Protocols
Flash Thermal Racemization for Chemoenzymatic Dynamic Kinetic Resolution of Chiral Amines
All PDFs of this category

Ausgabe 11/2023

Asymmetric Transfer Hydrogenation in Flow
All PDFs of this category

Ausgabe 10/2023

Atroposelective Dual Catalysis in Flow
A Continuous-Flow Electron-Poor-Arene Dearomatization via Photocatalyzed Cycloaddition
All PDFs of this category

Ausgabe 09/2023

Rapid Access to Benzodiazepines Using Flow Chemistry
Transformation of Amides to Nitriles Catalyzed by CeO2 in Continuous-Flow Synthesis
All PDFs of this category

Ausgabe 08/2023

Photochemical [2+2] Cycloaddition between Alkynes and Maleimides Using Continuous Flow
Microwave-Assisted C–C Bond Formation to Access Fused-Ring Compounds
All PDFs of this category

Ausgabe 07/2023

Enantioselective Synthesis of α-Alkylated Aldehydes Using Continuous Flow Chemistry and Visible Light
All PDFs of this category

Ausgabe 06/2023

Enantioselective Nickel-Catalyzed 1,4-Addition of Malonates with Nitroalkenes
All PDFs of this category

Ausgabe 05/2023

Effects of Different Substituents on the Regioselectivity of a Photocascade Reaction in Continuous Flow
All PDFs of this category

Ausgabe 04/2023

Segmented Continuous Flow Allows for Convenient Synthesis of Phenyl Glucosazone
All PDFs of this category

Ausgabe 03/2023

A Safe and Mild Protocol for the Synthesis of Dithiocarbamates under Continuous Flow Conditions
All PDFs of this category

Ausgabe 02/2023

Synthesis of Fentanyl Using Photoredox Catalysis under Flow
All PDFs of this category

Ausgabe 01/2023

Benzophenone-Photocatalytic C4-Alkylation of Pyridinium Salts from C–H Bonds in Continuous Flow
Flow-Type Switchable Oxidation to Form Carboxylic Acids and Aldehydes from Primary Alcohols
All PDFs of this category

Ausgabe 12/2022

Development of Continuous Flow System for β-Keto Ester Synthesis
Synthesis of Unsymmetrical Biaryls via Photoinduced Arylation of Chloroarenes in Flow
All PDFs of this category

Ausgabe 11/2022

Synthesis of α-Aminoamides by a Photocatalytic Continuous-Flow Reaction
Scalable Photoalkylation of Carbohydrates in Flow with a Sustainable Organocatalyst
Hydrogen-Transfer Reaction Using Packed-Column Catalysts in Flow
Photochemical Approach for the Synthesis of Tetrahydroimidazo[1,2-a]pyridine 1-Oxides
All PDFs of this category

Ausgabe 10/2022

Synthesis of Ketones via a Multiphoton Tandem Photoredox Protocol in Continuous Flow
Flow Synthesis of 1,4-Benzothiazines from (E)-β-Chlorovinyl Ketones and 2,2′-Sulfanyldianilines
All PDFs of this category

Ausgabe 09/2022

Palladium-Catalyzed Hydrogenation of Nitroolefins and Three-Step Homologation of Aldehydes
Photochemical Formal [3+2] Cycloaddition for the Synthesis of Aminocyclopentanes in Flow
Horner–Wadsworth–Emmons Olefination in Flow System by Photocatalysis
All PDFs of this category

Ausgabe 08/2022

Preparation of Organosodium Compounds by Flow System
Diastereoselective Synthesis of α-Chiral Piperidines in Flow
Synthesis of Unsymmetrically Substituted Phosphites and Phosphates Using a Flow System
Synthesis of Disulfides under Flow Conditions
All PDFs of this category

Ausgabe 07/2022

Electrochemical Oxidation of Primary Alcohol in Single-Pass Continuous Flow
Photochemical Synthesis of Alkyl Zinc Sulfinates under Flow Conditions
Aerobic Oxidations of Aldehydes in Continuous Flow Catalyzed by N-Hydroxyphthalimide
All PDFs of this category

Ausgabe 06/2022

Synthesis of (R)-Tamsulosin Using Heterogeneous Catalysis in Flow
Amide Bond Formation under Flow Conditions
All PDFs of this category

Ausgabe 05/2022

Alkyl Phosphonate Synthesis in a Continuous-Flow System
Oxidative Photocyclization of N-Arylenaminones to Indoles in Flow
Continuous Flow, Cyanide-Free Cyanation Procedure via a Suzuki Coupling, [4+2] retro-[4+2] Sequence
Efficient Synthesis of AZD4635 using Oxygen in Flow
All PDFs of this category

Ausgabe 04/2022

Multistep Closed-Loop Optimization for the Synthesis of Edavarone
Synthesis of (S)-Rolipram via Continuous Flow
All PDFs of this category

Ausgabe 03/2022

Sequential Diazo Transfer and Rhodium-Catalyzed O–H Insertion Enabled by the Use of an Azide Resin
Tropylium-Catalyzed Ritter Reaction under Flow Conditions
C–H Sulfonylation of Imidazoheterocycles through Electrochemical Activation in Flow
C–H Phosphorylation of Arenes under Flow Conditions
All PDFs of this category

Ausgabe 02/2022

Synthesis of Azetidinium Salts via Continuous-Flow
Palladium-Catalyzed Reductive Amination in an Oscillatory Plug-Flow Reactor
Leucinol-Catalyzed Asymmetric Aldol Reaction of Isatin and Acetone in Flow
Electrochemical C–H Bond Activation under Flow Conditions
Selective Heterogeneous Catalytic Hydrogenation of Nitriles in a Flow System
All PDFs of this category

Ausgabe 01/2022

Enantioselective Scandium Catalyzed C–C Bond-Forming Reactions in Continuous Flow
A Scalable Flow System for the Diels–Alder Reaction of Phenylacetylenes with Dicyclopentadiene
Flow-Type C–H Amidation to Afford α-Amino Acid Derivatives
Electrochemical Cross-Coupling of Arenes under Flow Conditions
All PDFs of this category

Ausgabe 12/2021

Chlorination of Alkenes under Flow Conditions
Flow Reaction of Cross-Coupling Reaction Between Alkylarenes and Aldehydes
Preparation and Utilization of N-Chloroamines under Continuous Flow
All PDFs of this category

Ausgabe 11/2021

Synthesis of 3-(Trifluoromethyl)-3-arylcyclopropenes under Flow Conditions
Photoredox-Catalyzed α-Trifluoromethoxylation of Ketones
Flow Approach to Interrupted Curtius Rearrangement of Proline Derivatives
Copper/Rhodium-Catalyzed Flow Synthesis of Chiral Cyclopropanes
Preparation of 2-Pyrrolidone by Photocatalytic 3-Component Cyclization in Flow
All PDFs of this category

Ausgabe 10/2021

Photocatalytic C(sp3)–H Heteroarylation in Flow
Decarboxylation and Decarboxylative Deuteration of Carboxylic Acids by Using a Ag–Bi Hybrid Material
A Fixed-Bed Approach for Wittig-Type Olefinations in Continuous Flow
Ozone-Mediated Oxidation of Amines and Pyridines under Flow Conditions
All PDFs of this category

Ausgabe 09/2021

Electrochemical Fluorination Reactions in Continuous Flow Using (Difluoroiodo)arene Mediators
Synthesis of α-Amino Acids by Electrochemical Carboxylation of Aldimines in a Flow System
Copper-Catalyzed Hydrosilylation of Alkynes and Alkenes under Blue LED Irradiation
Z-Selective Olefin Metathesis in Continuous Flow
All PDFs of this category

Ausgabe 08/2021

Single-Flow System for Acid Hydrolysis and Base Condensation
Continuous-Flow Synthesis of Isocyanides for Use in a Palladium-Catalyzed Domino Reaction
Stereoselective Photocatalytic Cyclization of Bisenones
Organophotocatalytic Aerobic Oxygenation under Visible-Light Irradiation
Kinetic Resolution of C2-Symmetric (±)-Diols in Flow by Sequential Organocatalytic Acylation
All PDFs of this category

Ausgabe 07/2021

N-Arylation of Amino Acid Esters using a Pd(OH)2 Packed-Bed Reactor
Bromine–Sodium Exchange and Directed Metalations in Continuous Flow
Synthesis of Fluorinated Tertiary Alcohol Derivatives under Visible-Light Irradiation
Ru-promoted Photooxidative C–H Functionalization of Isoquinolines in a Microflow Reactor
Precise Control of cis−trans Isomerization of α-Anionic Stilbenes under Flow Conditions
All PDFs of this category

Ausgabe 06/2021

Synthesis of [1.1.1]Propellane and Subsequent Functionalization in Continuous-Flow Processes
Synthesis of Indolo[2,1-a]isoquinoline Derivatives under Visible-Light Irradiation in Flow
Superacid and Flow Chemistry Approach towards Ferrier Rearrangement
Synthesis of Glyoxal Derivatives in Continuous Flow
Electrochemical Aza-Wacker Cyclization in Flow
All PDFs of this category

Ausgabe 05/2021

Catalytic Si–H Functionalization in Flow
UV-Mediated Synthesis of 1,3,4-Oxadiazoles in Flow
Improved Flow Synthesis of Remdesivir
Zirconium Oxide Catalyzed Amidation Reactions Using Unactivated Esters in Flow
Generation and Use of Pyrylium Tetrafluoroborates in Polymerization under Continuous-Flow Conditions
Synthesis of Primary Amides by Site-Selective Hydrolysis
Photocatalytic Hydrocarboxylation in Flow for β-Lactone Synthesis
All PDFs of this category

Ausgabe 04/2021

Halogen–Lithium Exchange on Isothiocyanate-Substituted Aryl Halides
Safer Handling of Diazomethane through Continuous Generation and Consumption
Oxidative Debenzylation of Protected Carbohydrates under Flow Conditions
Synthesis of Aminoimidazo Heterocycles under Flow Conditions
Generation and Use of Lithiated 1-Azabicyclo[1.1.0]butanes in Flow Microreactors
Selective Oxidation of Alcohols under Flow Conditions
All PDFs of this category

Ausgabe 03/2021

Synthesis of Hydroxy Esters under Flow Conditions
Rhodium-Catalyzed C–H Activation of Benzylamines for Olefin Hydroarylation
Continuous-Flow Procedure for the Synthesis of Benzotriazoles via [3+2] Cycloaddition
Asymmetric Synthesis of Chloramphenicol and Related Amphenicol Antibiotics
All PDFs of this category

Ausgabe 02/2021

Reactor-Based Enhanced Productivity in a Photocatalytic Alkylation
Micellar Aqueous Photo-Fries Rearrangement
Photochemical Hydrotrifluoromethylation of Unsaturated β-Keto Esters under Flow Conditions
Continuous-Flow Nickel/Photocatalytic C–N Cross-Coupling of Aryl Halides and Hydrazine Nucleophiles
All PDFs of this category

Ausgabe 01/2021

Continuous Flow Synthesis of a Lamivudine Intermediate
Metalation in Flow for the Synthesis of Highly Functionalized Unsaturated Compounds
Continuous-Flow Synthesis and Application of Nitrogen Transfer Agent Chloramine
thia-Diels–Alder Reaction in Continuous Flow Using Photochemically Generated Thioaldehydes
Continuous-Flow Photoisomerization–Cyclization Process for Quinoline Synthesis
Continuous Cryogenic Lithium–Halogen Exchange
Synthesis of Remdesivir
Continuous Flow Photo-oxidation of Cyclopentadiene
All PDFs of this category

Ausgabe 12/2020

Rhodium-Catalyzed Hydrogenation of Enamides and α-or β-Dehydroamino Acids
Asymmetric Conjugate Addition–Oxidation Sequence in Flow Generating GABA Analogues
Preparation and Use of Halomethyl Grignard Reagents in Continuous Flow
Progress toward Fully Automated Chemical Synthesis
All PDFs of this category

Ausgabe 11/2020

Asymmetric C–H Functionalization in Flow by an Immobilized Rhodium Carboxylate Catalyst
Iodine–Lithium Exchange Reaction of Benzylic Iodides
Iridium-Photocatalyzed Formation of Tetrahydroquinolines
All PDFs of this category

Ausgabe 10/2020

Selective Monoreduction of a Pyridine Diester on a Kilogram Scale
Development of an Efficient Flow Hydroformylation in a High-Throughput Single-Droplet Reactor
Scalable Electrochemical Cyclobutane Synthesis in Continuous Flow
Photocatalytic Carbonylative Amidation in Continuous Flow
Polymer-Supported Tin-Catalyzed Synthesis of Tetrazoles in Flow
Synthesis of Heteroaryl Sulfinates in Continuous Flow for Use in Palladium-Catalyzed Cross-Coupling
Aryl Amine Synthesis in an Integrated Packed-Bed Flow System
All PDFs of this category

Ausgabe 09/2020

C–H Activation of Gaseous Alkanes
Design of Flow Reactor for Efficient Kinetic Analysis
Protein Synthesis on Demand, and Make it Snappy!
Photocatalytic α-Tertiary Amine Synthesis via C–H Alkylation of Primary Amines
Biocatalytic Reduction of Keto Esters and Heterocyclic Ketones in Continuous Flow
Nonactivated C–H Methylation with Methanol by Using a Gallium Nitride Photocatalyst
All PDFs of this category

Ausgabe 08/2020

Synthesis of Deuterodifluoromethylated Alcohols and gem-Difluoroalkenes in Continuous Flow
Synthesis of Oxindoles by a Photo-Fenton Reaction
Polystyrene-Supported Carbodiimide: A Flow Protocol for Amide/Lactam Synthesis
Synthesis of Isocyanates from Carboxylic Acids in Continuous Flow
Selective Hydroboration/Oxidation of Alkenes Using 9-BBN under Flow Conditions
Stereospecific Amination Using Sodium Azide in Continuous Flow
Kinetic Resolution of BINOLs in Continuous Flow
All PDFs of this category

Ausgabe 07/2020

Synthesis of α-Chloro Aldehydes in a Flow Microreactor
Generation and Use of Fluoroorganolithiums in Flow Microreactors
All PDFs of this category

Ausgabe 06/2020

Peptide Synthesis in Continuous Flow
Aryl Alkyl Ether Formation via Copper-Catalyzed Photoredox Driven C–O Cross-Coupling
Flow Synthesis of Anilines through Photoredox/Ni(II)-Catalyzed C–N Cross-Coupling: Tetracaine
Aryl, Heteroaryl, and Benzylic Functionalization Using Potassium Organometallics Generated in Flow
All PDFs of this category

Ausgabe 05/2020

Metallaphotoredox Cross-Coupling of Drug-Like Aryl Halides with Bicyclo[1.1.1]pentane Trifluoroborate Salts
All PDFs of this category

Ausgabe 04/2020

Synthesis of Biaryl Compounds in Flow via a Lithiation, Borylation, Suzuki–Miyaura Cross-Coupling Pathway
Ferrocenyl Azide Synthesis via Halogen–Lithium Exchange in Continuous Flow
Acylation with Grignard Reagents in Continuous Flow
All PDFs of this category

Ausgabe 03/2020

Heterogeneous Catalysis in Continuous Flow
Organocatalyzed Rauhut–Currier and [3+2] Annulation Domino Reaction under Flow Conditions
Functionalized Aryl Azides through Aryllithium Generation in Flow
Continuous Palladium-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source
All PDFs of this category

Ausgabe 02/2020

Synthesis of ACE Inhibitors in Flow
Nickel-Catalyzed Cross-Couplings of Redox-Active Esters and Aryl Halides in Flow
Hydrogenation of Cinnolines into 1,4-Dihydrocinnolines in a Continuous Flow System
Photochemical Cleavage of 2-Nitrobenzyl Esters of Uronic Acids in Continuous Flow
Biocatalytic Oxidation of Saccharides in Continuous Flow
Wolff–Kishner Reductions Using a Silicon Carbide Flow Reactor
All PDFs of this category

Ausgabe 01/2020

Iron-Catalyzed Cross-Coupling Reaction in Flow
Continuous Process for Manufacturing 5-Bromo-N-(tert-butyl)pyridine-3-sulfonamide
Hydroperfluoroalkylation of Unsaturated Systems in Continuous Flow
Strongly Lewis Acidic MOF Catalysts for Continuous-Flow Reactions
Peptide Coupling with Unprotected Amino Acids in a Micro-Flow Reactor
Benzylic Lithiation of 1,3,4-Oxadiazoles in Batch and Continuous Flow
All PDFs of this category

Ausgabe 12/2019

Automation of Flow Syntheses by AI Synthetic Route Design and Implementation
[2+2] Cycloaddition of C60 with Allene Derived from Benzil and Methyl Propiolate
Carbonyl-Olefin Metathesis of Ketones and Vinyl Ethers
Flow Rhodoelectro-Catalyzed Alkyne Annulations
Continuous Flow Synthesis of Pyrazoles
Synthesis of TAK-071 Using Flash Chemistry
All PDFs of this category

Ausgabe 11/2019

Continuous Flow Electrochemical Oxidation of Alcohols
Functionalized Alkyllithium Reagents Towards Heterotelechelic Polymers
Radical-Based Late-Stage C−H 18F-Difluoromethylation of N-Heteroaromatics
Organocatalyzed Photooxygenation of β-Dicarbonyl Compounds in Flow Photomicroreactors
One-Step Synthesis of 2-Fluoroadenine in a Continuous Flow Operation
All PDFs of this category

Ausgabe 10/2019

Ibuprofen in Continuous Flow without Headache
Synthesis of α-CF2H-Substituted Ketones from Styrenes via Photoredox Catalysis in Flow
Three-Step Streamlined Flow Synthesis of Imatinib and Analogues
Continuous-Flow Photochemical Iodoperfluoroalkylation of Alkenes
All PDFs of this category

Ausgabe 09/2019

Ruthenium-Catalyzed Continuous-Flow Photochemical Alkoxylation of Styrenes
Palladium-Catalyzed Diazo Cross-Couplings
Synthesis of a Moxifloxacin Fragment
Synthesis of Hydroquinones through Sequential and Continuous-Flow Hydrogenation-Derivatization
Visible-Light-Promoted Iron-Catalyzed Cross-Coupling in Flow
Chemo-Enzymatic Baeyer–Villiger Oxidation in Continuous Flow
All PDFs of this category

Ausgabe 08/2019

Continuous-Flow Preparation of Alkynylzinc and its Subsequent Cross-Coupling Reaction
Continuous-Flow Electrochemical Oxidation with Hypervalent Iodine Reagents
Syntheses of Sulfilimines and Sulfoximines in a Flow System
Flow Synthesis of Vaborbactam
Flow Synthesis of Ceramide d-erythro-CER[NDS]
Synthesis of Sialic Acid Derivatives in a Continuous-Flow Enzymic Reactor
Cascade Oxidation over Contiguous Dual Catalyst Beds in Continuous Flow
All PDFs of this category

Ausgabe 07/2019

A Rapid Flow Synthesis of Linezolid
Scandium-Catalyzed Electrochemical Intramolecular Cross-Coupling
Continuous-Flow Diastereoselective Synthesis of Substituted Tetrahydrofurans
Ynones and Pyrazoles in Continuous Flow
Thermolytic Deprotection of N-Boc Groups
Continuous-Flow Production of 5-(Hydroxymethyl)furfural
All PDFs of this category

Ausgabe 06/2019

Light-Induced Beckmann Rearrangement in Continuous Flow
Continuous-Flow Friedel–Crafts Acylation by Zirconium–β-Zeolite Catalysis
Aldol Condensation Catalyzed by an Immobilized Base in Continuous Flow
An Immobilized Palladium Catalyst for Cross-Couplings in Continuous Flow
Gas/Liquid-Phase Microflow Trifluoromethylation with Fluoroform
All PDFs of this category

Ausgabe 05/2019

Continuous-Flow, Michaelis−Arbuzov Rearrangement
DFT Guides the Optimization of Photosensitized [2+2] Cycloadditions in Flow
Synthesis of Ketones from Organolithium Reagents in Continuous Flow
Flow Synthesis of Ciprofloxacin
Flow Synthesis of Lomustine
All PDFs of this category

Ausgabe 04/2019

Automated Titration of Organometallic Reagents in Continuous Flow
Oxidation of Csp3–H Bonds in Flow Using Methyl(trifluoromethyl)dioxirane
Continuous-Flow Chemoenzymatic Dynamic Kinetic Resolution of Amines
Continuous-Flow Diazotization
All PDFs of this category

Ausgabe 03/2019

Flow Synthesis of 3-(Mesitylthio)-1H-1,2,4-triazole
Flow Production of Anhydrous tert-Butyl Hydroperoxide
Homologation of Ketones and Aryl Aldehydes in Flow
A Laser-Driven Flow-Chemistry Platform for Scaling Photochemical Reactions
Heterogenous Platinum-Catalyzed Direct Reductive Amination
All PDFs of this category

Ausgabe 02/2019

Photoredox Arylation of Enol Acetates via Porphyrin Catalysis
C–H Functionalization of Aldehydes with Photolabile Diazo Precursors
Continuous Alcohol Amination by a Hydrogen-Borrowing Protocol
Generation and Cross-Coupling of Organozinc Reagents in Flow
Morita–Baylis–Hillman Reaction under Continuous-Flow Conditions
All PDFs of this category

Ausgabe 01/2019

Synthesis of Substituted Allylic Alcohols in Continuous Flow under UV-Light
A Catalytic Hydrogenation of Arenes: Batch versus Flow
Versatile Flow-Based Automatic Reaction Optimization Platform
Continuous Flow Synthesis of Eflornithine
Continuous-Flow Synthesis of Amines and Hydroxylamines
Chloroacetate Claisen Reactions in Continuous Flow
All PDFs of this category

Ausgabe 12/2018

Synthesis of N-Carboxyanhydrides in a Microflow Reactor
Combined Photoredox/Hydrogen Transfer for Functionalization of Nonactivated Alkanes
Iron-Catalyzed Arylhydroxylation in Continuous Flow
Light Absorption of a Palladium–Zinc Complex allows Negishi Cross-Couplings
Enantioselective Synthesis of Quaternary α-Amino Acids in Flow
Flow Synthesis of a Doravirine Fragment
All PDFs of this category

Ausgabe 11/2018

Asymmetric Synthesis of Isoxazolidines on a Polymeric Organocatalyst
Continuous Process for the Preparation of Thiazoles
All PDFs of this category