RSS-Feed abonnieren
DOI: 10.5999/aps.2014.41.5.588
Lymphedema Fat Graft: An Ideal Filler for Facial Rejuvenation
Lymphedema is a chronic disorder characterized by lymph stasis in the subcutaneous tissue. Lymphatic fluid contains several components including hyaluronic acid and has many important properties. Over the past few years, significant research has been performed to identify an ideal tissue to implant as a filler. Because of its unique composition, fat harvested from the lymphedema tissue is an interesting topic for investigation and has significant potential for application as a filler, particularly in facial rejuvenation. Over a 36-month period, we treated and assessed 8 patients with lymphedematous limbs who concurrently underwent facial rejuvenation with lymphedema fat (LF). We conducted a pre- and post-operative satisfaction questionnaire survey and a histological assessment of the harvested LF fat. The overall mean general appearance score at an average of 6 months after the procedure was 7.2±0.5, demonstrating great improvement. Patients reported significant improvement in their skin texture with a reading of 8.5±0.7 and an improvement in their self-esteem. This study demonstrates that LF as an ideal autologous injectable filler is clinically applicable and easily available in patients with lymphedema. We recommend the further study and clinical use of this tissue as it exhibits important properties and qualities for future applications and research.
This paper was presented at the 24th International Society of Lymphology Conference on September 16-20, 2013, in Rome, Italy.
Publikationsverlauf
Eingereicht: 17. März 2014
Angenommen: 14. Juni 2014
Artikel online veröffentlicht:
02. Juni 2022
© 2014. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Shih YC, Xu Y, Cormier JN. et al. Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up study. J Clin Oncol 2009; 27: 2007-2014
- 2 Liu N. Metabolism of macromolecules in tissue. Lymphat Res Biol 2003; 1: 67-70
- 3 Liu NF. Trafficking of hyaluronan in the interstitium and its possible implications. Lymphology 2004; 37: 6-14
- 4 Liu NF, Zhang LR. Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema. Lymphology 1998; 31: 173-179
- 5 Coleman SR. Structural fat grafts: the ideal filler?. Clin Plast Surg 2001; 28: 111-119
- 6 Salgado CJ, Mardini S, Spanio S. et al. Radical reduction of lymphedema with preservation of perforators. Ann Plast Surg 2007; 59: 173-179
- 7 Rohrich RJ, Ghavami A, Crosby MA. The role of hyaluronic acid fillers (Restylane) in facial cosmetic surgery: review and technical considerations. Plast Reconstr Surg 2007; 120: 41S-54S
- 8 Lam SM, Glasgold RA, Glasgold MJ. Limitations, complications, and long-term sequelae of fat transfer. Facial Plast Surg Clin North Am 2008; 16: 391-399
- 9 Pinski KS, Roenigk Jr HH. Autologous fat transplantation. Long-term follow-up. J Dermatol Surg Oncol 1992; 18: 179-184
- 10 Keyhan SO, Hemmat S, Badri AA. et al. Use of platelet-rich fibrin and platelet-rich plasma in combination with fat graft: which is more effective during facial lipostructure?. J Oral Maxillofac Surg 2013; 71: 610-621
- 11 Levi B, Glotzbach JP, Sorkin M. et al. Molecular analysis and differentiation capacity of adipose-derived stem cells from lymphedema tissue. Plast Reconstr Surg 2013; 132: 580-589
- 12 Alghoul M, Mendiola A, Seth R. et al. The effect of hyaluronan hydrogel on fat graft survival. Aesthet Surg J 2012; 32: 622-633
- 13 Andre P. Hyaluronic acid and its use as a "rejuvenation" agent in cosmetic dermatology. Semin Cutan Med Surg 2004; 23: 218-222
- 14 Liu N, Shao L, Xu X. et al. Hyaluronan metabolism in rat tail skin following blockage of the lymphatic circulation. Lymphology 2002; 35: 15-22
- 15 Aschen S, Zampell JC, Elhadad S. et al. Regulation of adipogenesis by lymphatic fluid stasis: part II. Expression of adipose differentiation genes. Plast Reconstr Surg 2012; 129: 838-847