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CC BY-NC-ND 4.0 · Sleep Sci 2022; 15(03): 297-304
DOI: 10.5935/1984-0063.20220054
ORIGINAL ARTICLES

The association between narcolepsy during pregnancy and maternal-fetal risk factors/outcomes

Annise Wilson
1   Baylor College of Medicine, Center of Excellence in Health Equity, Training, and Research - Houston - TX - United States
,
Deepa Dongarwar
1   Baylor College of Medicine, Center of Excellence in Health Equity, Training, and Research - Houston - TX - United States
,
Krystal Carter
1   Baylor College of Medicine, Center of Excellence in Health Equity, Training, and Research - Houston - TX - United States
,
Maricarmen Marroquin
1   Baylor College of Medicine, Center of Excellence in Health Equity, Training, and Research - Houston - TX - United States
,
Hamisu M Salihu
1   Baylor College of Medicine, Center of Excellence in Health Equity, Training, and Research - Houston - TX - United States
2   Baylor College of Medicine, Department of Family Medicine - Houston - TX - United States
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Objective We sought to determine whether narcolepsy in pregnancy is associated with adverse maternal-fetal outcomes.

Material and Methods A retrospective, cross-sectional analysis was performed using the nationwide inpatient sample (NIS) for the period 2008-2017. The primary exposure was narcolepsy with cataplexy, narcolepsy type 1 (NT1), and without cataplexy, narcolepsy type 2 (NT2), and the endpoints were a composite of maternal-fetal outcomes or risk factors.

Results A total of 7,742 hospitalizations among pregnant women with narcolepsy were identified (prevalence = 17.6 per 100,000), of which 6,769 (88%) were diagnosed with NT2. Statistically significant positive associations were found between narcolepsy and the following conditions: obesity (odds ratio (OR): 2.99, confidence interval (CI): 2.4-3.74), anemia (OR=1.41, CI: 1.13-1.77), pre-pregnancy hypertension (OR=1.93, CI: 1.37-2.7), pre-pregnancy diabetes (OR=1.7, CI: 1.08-2.84), and gestational hypertension (OR=1.58, CI: 1.13-2.20) in the ICD-9 group. Similar findings were noted in the ICD-10 group with the exception of gestational hypertension, gestational diabetes, and anemia.

Conclusion Given these important findings, we propose a global approach of screening for narcolepsy among women of reproductive age with pre-existing risk factors prior to conception to minimize pregnancy complications.

Narcolepsy - Cataplexy - Pregnancy - Delivery - Obstetric - Morbidity - Hospitalization


Publication History

Received: 05 October 2021

Accepted: 10 January 2022

Article published online:
01 December 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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