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CC BY-NC-ND 4.0 · Sleep Sci 2019; 12(02): 79-87
DOI: 10.5935/1984-0063.20190071
ORIGINAL ARTICLE

Sleepiness comorbid to musculoskeletal pain is associated with worse quality of life and mood symptoms in a general population sample

Camila Hirotsu
1   Centre Hospitalier Universitaire Vaudois, Centre Hospitalier Universitaire Vaudois - Lausanne - Lausanne - Switzerland.
,
Cristina Frange
2   Universidade Federal de São Paulo, Department of Neurology and Neurosurgery - São Paulo - São Paulo - Brazil.
,
Patricia H Hirata
3   Universidade Federal de São Paulo, Department of Psychobiology - São Paulo - São Paulo - Brazil.
,
Renata C Cremaschi
3   Universidade Federal de São Paulo, Department of Psychobiology - São Paulo - São Paulo - Brazil.
,
Fernando M Coelho
2   Universidade Federal de São Paulo, Department of Neurology and Neurosurgery - São Paulo - São Paulo - Brazil.
3   Universidade Federal de São Paulo, Department of Psychobiology - São Paulo - São Paulo - Brazil.
,
Monica L Andersen
3   Universidade Federal de São Paulo, Department of Psychobiology - São Paulo - São Paulo - Brazil.
,
Sergio Tufik
3   Universidade Federal de São Paulo, Department of Psychobiology - São Paulo - São Paulo - Brazil.
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Objectives Musculoskeletal (MSK) pain and hypersomnolence (HPS) are very disabling conditions that may share some pathophysiological factors. This study aimed to evaluate the interaction between MSK pain and HPS and its association with mood symptoms, fatigue, quality of life, and both objective and subjective sleep quality.

Design Cross-sectional study.

Setting General population based sample.

Participants 510 individuals from EPISONO cohort, São Paulo (Brazil).

Measurements All participants completed questionnaires, had clinical assessment and underwent a full-night polysomnography. HPS was defined according to Epworth Sleepiness Scale while the presence of MSK pain was defined by structured questionnaire. The sample was allocated into 4 groups: control (CTRL, n=281), HPS (n=141), MSK (n=50), and both conditions (HPS+MSK, n=38).

Results MSK pain and HPS by themselves were associated with worse mood symptoms and quality of life. However, individuals with both associated conditions (HPS+MSK) presented higher frequencies of moderate to severe depression (44.1%) and anxiety symptoms (45.7%), as well as an additional decrease in quality of life compared to the other groups. There were no differences between HPS+MSK and MSK groups in objective sleep pattern. With regard to subjective sleep, HPS+MSK presented a higher prevalence of sleep attacks and cataplexy compared to all other groups.

Conclusions The combination of MSK pain and HPS was associated with worse mood symptoms, quality of life and HPS-related features. This study suggests that sleepiness may be an important symptom to be investigated and treated in MSK pain-related conditions for a better quality of life.

Sleep - Musculoskeletal Pain - Disorders of Excessive Somnolence - Mood Disorders - Quality of Life.


Publication History

Received: 13 July 2018

Accepted: 05 February 2019

Article published online:
31 October 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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