CC BY-NC-ND 4.0 · Sleep Sci 2019; 12(02): 110-115
DOI: 10.5935/1984-0063.20190068
REVIEW

Repercussion of medium and long treatment period with continuous positive airways pressure therapy in heart rate variability of obstructive sleep apnea

Fernanda Jesus Correia
1   Universidade Estadual do Sudoeste da Bahia, Departamento de Saúde I - Jequié - Bahia - Brazil.
,
Luiz Eduardo Barreto Martins
2   Universidade Estadual de Campinas, Departamento de Ciências do Esporte - Campinas - São Paulo - Brazil.
,
Daniel Matos Barreto
3   Universidade Estadual do Sudoeste da Bahia, Departamento de Ciências Naturais - Vitória da Conquista - Bahia - Brazil.
,
Karla Rocha Pithon
1   Universidade Estadual do Sudoeste da Bahia, Departamento de Saúde I - Jequié - Bahia - Brazil.
› Author Affiliations

Introduction Obstructive sleep apnea (OSA) is a respiratory sleep disorder. Many of these patients also exhibit autonomic alterations which can be observed through heart rate variability (HRV). Currently, one of the treatments for apnea is continuous positive airway pressure (CPAP).

Objective To observe OSA patients treated with CPAP exhibit HRV changes at medium and long treatment period.

Methods This is an integrative literature review conducted in May of 2018. The databases used for this research were PubMed, Scopus, Scielo and Pedro, the keywords used were “heart rate variability”, “obstructive sleep apnea” and “CPAP”. In this review was included original, published, randomized and non-randomized articles, released in the English language, before and up to April 2018, which specified the effects of CPAP therapy in autonomic dysfunction through the analysis of the HRV of patients diagnosed with OSA after at least one month of therapy.

Results The research of the literature produced 113 articles. After excluding duplicates and applying the inclusion and exclusion criteria, 8 articles were selected for this review.

Conclusion It was concluded that CPAP therapy is related to change in heart rate variability in patients with obstructive sleep apnea.



Publication History

Received: 30 July 2018

Accepted: 11 April 2019

Article published online:
31 October 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 
  • REFERENCES

  • 1 Pham LV, Schwartz AR. The pathogenesis of obstructive sleep apnea. J Thorac Dis. 2015;7(8):1358-72.
  • 2 Maeder MT, Schoch OD, Rickli H. A clinical approach to obstructive sleep apnea as a risk factor for cardiovascular disease. Vasc Health Risk Manag. 2016;12:85-103.
  • 3 Tufik S, Santos-Silva R, Taddei JA, Bittencourt LR. Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med. 2010;11(5):441-6.
  • 4 Ramar K, Dort LC, Katz SG, Lettieri CJ, Harrod CG, Thomas SM, et al. Clinical Practice Guideline for the Treatment of Obstructive Sleep Apnea and Snoring with Oral Appliance Therapy: An Update for 2015. J Clin Sleep Med. 2015;11(7):773-827.
  • 5 White J, Cates CJ, Wright JJ. Continuous positive airways pressure for obstructive sleep apnoea. Cochrane Database Syst Rev. 2001;(4):CD001106.
  • 6 Zamarrón C, Valdés Cuadrado L, Álvarez-Sala R. Pathophysiologic mechanisms of cardiovascular disease in obstructive sleep apnea syndrome. Pulm Med. 2013;2013:521087.
  • 7 Garvey JF, Pengo MF, Drakatos P, Kent BD. Epidemiological aspects of obstructive sleep apnea. J Thorac Dis. 2015;7(5):920-9.
  • 8 Park DH, Shin CJ, Hong SC, Yu J, Ryu SH, Kim EJ, et al. Correlation between the severity of obstructive sleep apnea and heart rate variability indices. J Korean Med Sci. 2008;23(2):226-31.
  • 9 Gammoudi N, Ben Cheikh R, Saafi MA, Sakly G, Dogui M. Cardiac autonomic control in the obstructive sleep apnea. Libyan J Med. 2015;10:26989.
  • 10 Mendes KDS, Silveira RCCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Context Enferm. 2008;17(4):758-64.
  • 11 Dal-Fabbro C, Garbuio S, D’Almeida V, Cintra FD, Tufik S, Bittencourt L. Mandibular advancement device and CPAP upon cardiovascular parameters in OSA. Sleep Breath. 2014;18(4):749-59.
  • 12 Tasali E, Chapotot F, Leproult R, Whitmore H, Ehrmann DA. Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011;96(2):365-74.
  • 13 Limphanudom P, Chierakul N, Pinyopattarakul N, Nana A, Naruman C, Tangchityongsiva S, et al. Recovery of heart rate variability in patients with moderate to severe obstructive sleep apnea after 6-month continuous positive airway pressure treatment. J Med Assoc Thai. 2007;90(8):1530-5.
  • 14 Shiina K, Tomiyama H, Takata Y, Yoshida M, Kato K, Saruhara H, et al. Effects of CPAP therapy on the sympathovagal balance and arterial stiffness in obstructive sleep apnea. Respir Med. 2010;104(6):911-6.
  • 15 Ferland A, Poirier P, Sériès F. Sibutramine versus continuous positive airway pressure in obese obstructive sleep apnoea patients. Eur Respir J. 2009;34(3):694-701.
  • 16 Roche F, Court-Fortune I, Pichot V, Duverney D, Costes F, Emonot A, et al. Reduced cardiac sympathetic autonomic tone after long-term nasal continuous positive airway pressure in obstructive sleep apnoea syndrome. Clin Physiol. 1999;19(2):127-34.
  • 17 Seaborn GEJ, Pang H, Akl SG, Redfearn DP, Simpson CS, Fitzpatrick M, et al. Autonomic profile of patients referred to a sleep disorder clinic: impact of CPAP on the autonomic nervous system. Rev Urug Cardiol. 2012;27(2):143-7.
  • 18 Chrysostomakis SI, Simantirakis EN, Schiza SE, Karalis IK, Klapsinos NC, Siafakas NM, et al. Continuous positive airway pressure therapy lowers vagal tone in patients with obstructive sleep apnoea-hypopnoea syndrome. Hellenic J Cardiol. 2006;47(1):13-20.
  • 19 Mansukhani MP, Kara T, Caples SM, Somers VK. Chemoreflexes, sleep apnea, and sympathetic dysregulation. Curr Hypertens Rep. 2014;16(9):476.
  • 20 Liang J, Zhang X, Luo Y, Wang T, Sun L, Huang S. The Impact of Respiratory Events on the Autonomic Nervous System during Sleep. Int Heart J. 2018;59(2):378-86.