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CC BY-NC-ND 4.0 · Sleep Sci 2017; 10(01): 47-54
DOI: 10.5935/1984-0063.20170008
ORIGINAL ARTICLE

Olfactory impairment is related to REM sleep deprivation in rotenone model of Parkinson's disease

Mariana F. Aurich
1   Laboratório de Neurofisiologia. Departamento de Fisiologia. Universidade Federal do Paraná, Curitiba, PR, Brazil.
,
Lais S. Rodrigues
1   Laboratório de Neurofisiologia. Departamento de Fisiologia. Universidade Federal do Paraná, Curitiba, PR, Brazil.
,
Adriano D. S. Targa
1   Laboratório de Neurofisiologia. Departamento de Fisiologia. Universidade Federal do Paraná, Curitiba, PR, Brazil.
,
Ana Carolina D. Noseda
1   Laboratório de Neurofisiologia. Departamento de Fisiologia. Universidade Federal do Paraná, Curitiba, PR, Brazil.
,
Flávia D. W. Cunha
1   Laboratório de Neurofisiologia. Departamento de Fisiologia. Universidade Federal do Paraná, Curitiba, PR, Brazil.
,
Marcelo M. S. Lima
1   Laboratório de Neurofisiologia. Departamento de Fisiologia. Universidade Federal do Paraná, Curitiba, PR, Brazil.
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Abstract

Introduction Olfactory dysfunction affects about 85-90% of Parkinson's disease (PD) patients with severe deterioration in the ability of discriminate several types of odors. In addition, studies reported declines in olfactory performances during a short period of sleep deprivation. Besides, PD is also known to strongly affect the occurrence and maintenance of rapid eye movement (REM) sleep.

Methods Therefore, we investigated the mechanisms involved on discrimination of a social odor (dependent on the vomeronasal system) and a non-social odor (related to the main olfactory pathway) in the rotenone model of PD. Also, a concomitant impairment in REM sleep was inflicted with the introduction of two periods (24 or 48 h) of REM sleep deprivation (REMSD). Rotenone promoted a remarkable olfactory impairment in both social and non-social odors, with a notable modulation induced by 24 h of REMSD for the non-social odor.

Results Our findings demonstrated the occurrence of a strong association between the density of nigral TH-ir neurons and the olfactory discrimination capacity for both odorant stimuli. Specifically, the rotenone-induced decrease of these neurons tends to elicit reductions in the olfactory discrimination ability.

Conclusions These results are consistent with the participation of the nigrostriatal dopaminergic system mainly in the olfactory discrimination of a non-social odor, probably through the main olfactory pathway. Such involvement may have produce relevant impact in the preclinical abnormalities found in PD patients.

Olfactory discrimination - Dopamine - Rotenone - REM sleep deprivation - Parkinson disease


Publication History

Received: 27 October 2016

Accepted: 19 December 2016

Article published online:
29 September 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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