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CC BY-NC-ND 4.0 · World J Nucl Med 2020; 19(01): 78-81
DOI: 10.4103/wjnm.WJNM_92_18
Case Report

68Ga-DOTATATE positron emission tomography/computed tomography to detect the recurrence of phosphaturic mesenhcymal tumor-induced osteomalacia

Manav I. Bhalla
Department of Radiology, Froedtert Hospital and The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
,
Kennedy M. Wirtz
Department of Radiology, Froedtert Hospital and The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
,
Eric S. Fair
Department of Radiology, Froedtert Hospital and The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
,
Daniel J. Bucklan
Department of Radiology, Froedtert Hospital and The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
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Abstract

68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) has shown superiority over111Indium-octreotide scanning for the detection of phosphaturic mesenchymal tumors (PMTs). We report a case of tumor-induced osteomalacia resulting from PMT which, although initially clinically suspected, was not localized on octreotide scintigraphy performed several years prior. Subsequent surgical excision of a presumed benign osseous lesion a few years later revealed the diagnosis on pathology. Imaging assessment using 68Ga-DOTATATE PET/CT following recent clinical suspicion for recurrence revealed an intense tracer-avid lesion at the primary tumor site. DOTATATE imaging plays an important role in localizing tumors with high somatostatin receptor expression, such as neuroendocrine tumors (pheochromocytoma, paraganglioma, and neuroblastoma), meningioma, and mesenchymal tumors, causing oncogenic osteomalacia.

Keywords

68Ga-DOTATATE - phosphaturic mesenchymal tumor - positron emission tomography - somatostatin receptors - tumor-induced osteomalacia

Financial support and sponsorship

Nil.




Publication History

Received: 23 October 2011

Accepted: 09 November 2018

Article published online:
19 April 2022

© 2020. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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