Download PDF
CC BY-NC-ND 4.0 · World J Nucl Med 2020; 19(01): 69-71
DOI: 10.4103/wjnm.WJNM_5_19
Case Report

Incidental breast lesion detected by technetium-99m sestamibi scintigraphy in a patient with primary hyperparathyroidism

Sakditad Saowapa
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
,
Wichana Chamroonrat
1   Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
,
Ronnarat Suvikapakornkul
2   Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
,
Chutintorn Sriphrapradang
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Nuclear scintigraphy is functional imaging and can be combined with anatomical imaging to improve diagnostic yield. Detection of parathyroid lesion by technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) can facilitate an appropriate operative approach in a patients with primary hyperparathyroidism. Tc-99m MIBI is concentrated in highly cellular or metabolically active tissues, which have abundant mitochondria. False-positive scintigraphic findings could be from head-and-neck carcinomas, thyroid neoplasm, and multinodular goiter. In addition, multiple organs outside of the neck region, such as lung and breast, can take up the Tc-99m MIBI. Herein, we report the occurrence of abnormal focal uptake in the breast region during the preoperative localization of parathyroid adenoma and later discovered breast carcinoma.

Keywords

Breast neoplasms - incidental findings - parathyroid neoplasm - radionuclide imaging

Financial support and sponsorship

Nil.




Publication History

Received: 14 January 2019

Accepted: 30 January 2019

Article published online:
19 April 2022

© 2020. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Hruska CB, Phillips SW, Whaley DH, Rhodes DJ, O'Connor MK. Molecular breast imaging: Use of a dual-head dedicated gamma camera to detect small breast tumors. AJR Am J Roentgenol 2008;191:1805-15.
  • 2 Gellett LR, Farmer KD, Vivian GC. Tc-99m sestamibi uptake in a patient with gynecomastia: A potential pitfall in the diagnosis of breast cancer. Clin Nucl Med 1999;24:466.
  • 3 Sutter CW, Stadalnik RC. Noncardiac uptake of technetium-99m sestamibi: An updated gamut. Semin Nucl Med 1996;26:135-40.
  • 4 Karacavus S, Ede H, Sarikaya S, Delibas N, Kaya E, Erbay AR, et al. The importance of the incidental thyroid gland uptake during Tc-99m MIBI myocardial perfusion scintigraphy. Eur Rev Med Pharmacol Sci 2015;19:2781-5.
  • 5 Homma T, Manabe O, Ichinokawa K, Yamashita H, Oyama-Manabe N, Kato F, et al. Breast cancer detected as an incidental finding on 99mTc-MIBI scintigraphy. Acta Radiol Open 2017;6:2058460117715665.
  • 6 Kao CH, Wang SJ, Chen CY, Yeh SH. Detection of esophageal carcinoma using Tc-99m MIBI SPECT imaging. Clin Nucl Med 1994;19:1069-74.
  • 7 Caner B, Kitapçl M, Unlü M, Erbengi G, Calikoǧlu T, Göǧüş T, et al. Technetium-99m-MIBI uptake in benign and malignant bone lesions: A comparative study with technetium-99m-MDP. J Nucl Med 1992;33:319-24.
  • 8 Sutter CW, Shelton DK. Tc-99m sestamibi uptake and retention in a large hepatoma. Clin Nucl Med 1995;20:1091.
  • 9 Cohen MC, Rastegar JK, DeSilva RA, Hill TC. Demonstration of non-Hodgkin's lymphoma by dual radionuclide myocardial perfusion imaging. J Nucl Cardiol 1996;3:186-7.