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CC BY-NC-ND 4.0 · South Asian J Cancer 2018; 07(03): 163-166
DOI: 10.4103/sajc.sajc_82_18
ORIGINAL ARTICLE: Breast Cancer

Breast-conserving radiotherapy with simultaneous integrated boost; field-in-field three-dimensional conformal radiotherapy versus inverse intensity-modulated radiotherapy – A dosimetric comparison: Do we need intensity-modulated radiotherapy?

Bindhu Joseph
Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Nisma Farooq
Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Sabari Kumar
Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
C.R Vijay
Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Kurian J. Puthur
Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
C. Ramesh
Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Vishwanath Lokesh
Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
› Author Affiliations Source of Support: Nill.
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Abstract

Background and Purpose: To examine the feasibility of improving breast-conserving radiotherapy with simultaneous integrated boost (SIB) and analyzing the efficiency of forward versus inverse intensity-modulated radiotherapy (IMRT) techniques in providing the same. Materials and Methods: Three-dimensional conformal radiotherapy (3DCRT) field-in-field (FIF) plans with simultaneous and sequential boost and IMRT SIB plans were generated for the datasets of 20 patients who had undergone breast-conserving surgery. The 3 plans were compared dosimetrically for efficiency in terms of planning target volume (PTV) coverage (PTV 95%), homogeneity and conformity, dose delivered to ipsilateral/contralateral lungs (I/L: V10, V20, C/L: Vmean, V5), heart and contralateral breast (Vmean, V30 for heart and Vmean, V1, V5 for C/L breast). Results: The FIF 3DCRT plan with SIB (PLAN B) was more homogeneous than the classical technique with sequential boost (PLAN A). There were less hot spots in terms of Dmax (63.7 ± 1.3) versus Dmax (68.9 ± 1), P < 0.001 and boost V107%, B (0.3 ± 0.7) versus A (3.5 ± 5.99), P = 0.001. The IMRT SIB (PLAN C) did not provide any significant dosimetric advantage over the 3DCRT SIB technique. IMRT SIB plan C was associated with increased dose to contralateral lung in-terms of V5 (10.35 +/- 18.23) vs. (1.13 +/- 4.24), P = 0.04 and Vmean (2.12 ± 2.18) versus Vmean (0.595 ± 0.89), P = 0.008. There was 3-fold greater exposure in terms of Monitor Unit (MU) (1024.9 ± 298.32 versus 281.05 ± 20.23, P < 0.001) and treatment delivery time. Conclusions: FIF 3DCRT SIB provides a dosimetrically acceptable and technically feasible alternative to the classical 3DCRT plan with sequential boost for breast-conserving radiotherapy. It reduces treatment time by 2 weeks. IMRT SIB does not appear to have any dosimetric advantage; it is associated with significantly higher doses to contralateral lung and heart and radiation exposure in terms of MU.

Key words

Field-in-field three-dimensional conformal radiotherapy breast - intensity-modulated radiotherapy breast - simultaneous integrated boost


Publication History

Article published online:
22 December 2020

© 2018. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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