CC BY-NC-ND 4.0 · Journal of Diabetes and Endocrine Practice 2021; 04(02): 83-85
DOI: 10.4103/jdep.jdep_8_21
Case Report

Clopidogrel induced autoimmune hypoglycemia

Abdulla Alnuaimi
1   Division of Endocrinology, Tawam Hospital, Alain
,
Bachar Afandi
1   Division of Endocrinology, Tawam Hospital, Alain
,
Yusra Othman
2   Department of Laboratory Medicine, Tawam Hospital, Alain
› Institutsangaben

We report insulin autoimmune syndrome in a diet-controlled type 2 diabetes mellitus patient. She developed recurrent attacks of severe hypoglycemia 1 week after the initiation of clopidogrel. The evaluation revealed high insulin and C-peptide levels consistent with hyperinsulinemic hypoglycemia. The insulin-to-C-peptide ratio was reversed and >50. Anti-insulin antibody titers were highly positive.

Financial support and sponsorship

Nil.




Publikationsverlauf

Eingereicht: 10. März 2021

Angenommen: 02. April 2021

Artikel online veröffentlicht:
06. Juli 2022

© 2021. Gulf Association of Endocrinology and Diabetes (GAED). All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Schovánek J, Cibičková U, Čtvrtlík F, Fryšák Z, Karásek D. Differential diagnosis of hypoglycemia. Vnitr Lek 2020;66:129-33.
  • 2 Bansal N, Weinstock RS. Non-Diabetic Hypoglycemia. 2020 May 20. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, et al., Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 27099902.
  • 3 Cryer PE, Axelrod L, Grossman AB, Heller SR, Montori VM, Seaquist ER, et al. Evaluation and management of adult hypoglycemic disorders: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2009;94:709-28.
  • 4 Whipple AO, Frantz VK. Adenoma of islet cell tumors with hyperinsulinism. Am Surg 1935;101:1299-335.
  • 5 Yamada E, Okada S, Saito T, Osaki A, Ozawa A, Yamada M. Insulin autoimmune syndrome during the administration of clopidogrel. J Diabetes 2016;8:588-9.
  • 6 Rajpal A, Kassem LS, Moscoso-Cordero M, Arafah BM. Clopidogrel-induced insulin autoimmune syndrome: A newly recognized cause of hypoglycemia in a patient without diabetes. J Endocr Soc 2017;1:1217-23.
  • 7 Calder GL, Ward GM, Sachithanandan N, MacIsaac RJ. Insulin autoimmune syndrome: A case of clopidogrel-induced autoimmune hypoglycemia. J Clin Endocrinol Metab 2020;105:dgz301.
  • 8 Jiang Y, Wang L, Shi F, Zhou H, Zheng J, Cai J, et al. Insulin autoimmune syndrome after exposure to clopidogrel: A case report. Endocr Metab Immune Disord Drug Targets 2020;20:1355-62.
  • 9 Almutairi MZ, Aljumah HA. Insulin autoimmune syndrome (Hirata Disease): Case report in a saudi female patient with graves' disease and literature review. J Diabetes Endocr Pract 2020;3:12-4
  • 10 Uchigata Y, Eguchi Y, Takayama-Hasumi S, Omori Y. Insulin autoimmune syndrome (Hirata disease): Clinical features and epidemiology in Japan. Diabetes Res Clin Pract 1994;22:89-94.
  • 11 Taylor SI, Barbetti F, Accili D, Roth J, Gorden P. Syndromes of autoimmunity and hypoglycemia. Autoantibodies directed against insulin and its receptor. Endocrinol Metab Clin North Am 1989;18:123-43.
  • 12 Nature S, DePrisco C, Lurie A. Severe autoimmune hypoglycemia with insulin antibodies necessitating plasmapheresis. Endocr Pract 2004;10:49-54.