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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2021; 31(S 01): S178-S181
DOI: 10.4103/ijri.IJRI_944_20
Case Series

The utility of HRCT in the initial diagnosis of COVID-19 pneumonia—An Indian perspective

Rohan Kashyape
Medall Spark Diagnostics, Nashik, Maharashtra
,
Richa Jain
Aster CMI Hospital New Airport Road, NH-7, Outer Ring Rd, Sahakar Nagar, Bengaluru, Karnataka, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

A total of 1,499 patients who underwent High Resolution Computed tomography (HRCT) chest in the duration of 2 months for suspected COVID-19 pneumonia were included. Subjects included were those who had tested positive for the virus on RT-PCR, those with symptoms suspicious for COVID-19 infection awaiting results for the RT-PCR test or with negative result but strong clinical suspicion as well as those with exposure to proven patients based on contact tracing. Thus, both symptomatic as well as asymptomatic patients were included. The positive predictive value of HRCT was 85%, sensitivity was 73% for all patients. Overall, accuracy was 68%. There was no significant difference in these values for symptomatic and asymptomatic individuals. These results were also independent of the time of scan from the onset of symptoms or contact. Thus, we propose that HRCT is an excellent adjunct for initial diagnosis of COVID-19 pneumonia in both symptomatic and asymptomatic individuals in addition to the role of prognostic indicator for COVID-19 pneumonia.

Keywords

COVID-19 - diagnosis - high resolution computed tomography


Publication History

Received: 15 December 2020

Accepted: 15 December 2020

Article published online:
13 July 2021

© 2021. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Kucirka L, Lauer S, Laeyendecker O, Boon D, Lessler J. Variation in false-negative rate of reverse transcriptase polymerase chain reaction-based SARS-Cov-2 tests by time since exposure. Ann Intern Med. 2020; 173: 262-7
    CrossrefPubMedGoogle Scholar
  • 2 Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P. et al. Sensitivity of chest CT for COVID-19: Comparison to RT-PCR. Radiology 2020; 296: E115-7
    CrossrefPubMedGoogle Scholar
  • 3 Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z. et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics Pediatrics 2020; doi: 10.1542/peds.2020-0702
  • 4 Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19): A systematic review of imaging findings in 919 patients. AJR Am J Roentgenol 2020; 215: 87-93
    CrossrefPubMedGoogle Scholar
  • 5 Parry AH, Wani AH, Yaseen M, Jehangir M, Choh NA, Dar KA. Spectrum of chest computed tomographic (CT) findings in coronavirus disease-19 (COVID-19) patients in India. Eur J Radiol 2020; 129: 109147
    CrossrefPubMedGoogle Scholar
  • 6 Pan Y, Guan H, Zhou S, Wang Y, Li Q, Zhu T. et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): A study of 63 patients in Wuhan, China. Eur Radiol 2020; 30: 3306-9
    CrossrefPubMedGoogle Scholar
  • 7 Caruso D, Zerunian M, Polici M, Pucciarelli F, Polidori T, Rucci C. et al. Chest CT features of COVID-19 in Rome, Italy. Radiology 2020; 296: E79-85
    CrossrefPubMedGoogle Scholar
  • 8 Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): A pictorial review. Eur Radiol 2020; 30: 4381-9
    CrossrefPubMedGoogle Scholar
  • 9 Li R, Pei S, Chen B, Song Y, Zhang T, Yang W. et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARSCoV2). Science Science 2020; 368: 489-93
    PubMedGoogle Scholar
  • 10 West CP, Montori VM, Sampathkumar P. COVID-19 testing: The threat of false-negative results. Mayo Clin Proc 2020; 95: 1127-9
    CrossrefPubMedGoogle Scholar
  • 11 Real-time RT-PCR in COVID-19 detection: Issues affecting the results dx.doi.org/10.1080%2F14737159.2020.1757437.
  • 12 Kucirka LM, Lauer SA, Laeyendecker O, Boon D, Lessler J. Variation in false-negative rate of reverse transcriptase polymerase chain reaction–based SARS-CoV-2 tests by time since exposure. Ann Intern Med 2020:M20-1495. doi.org/10.7326/M20-1495.
  • 13 SUMMARY COVID-19 RT-PCR TEST – FDA.www.fda.gov/media/136151/download. [Last accessed on 2020 Apr 15].
  • 14 Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DKW. et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill 2020; 25: 2000045
    CrossrefPubMedGoogle Scholar
  • 15 Ooi EE, Low JG. Asymptomatic SARS-CoV-2 infection. Lancet Infect Dis 2020; 20: 996-8
    CrossrefPubMedGoogle Scholar
  • 16 Altschul DJ, Unda SR, Benton J, de la Garza Ramos R, Cezayirli P, Mehler M. et al. A novel severity score to predict inpatient mortality in COVID-19 patients. Sci Rep 2020; 10: 16726
    CrossrefPubMedGoogle Scholar
  • 17 Larke FJ, Kruger RL, Cagnon CH, Flynn MJ, McNitt-Gray MM, Wu X. et al. Estimated radiation dose associated with low-dose chest CT of average-size participants in the national lung screening trial 3. AJR Am J Roentgenol 2011; 197: 1165-9
    CrossrefPubMedGoogle Scholar
  • 18 Ravenel JG, Scalzetti EM, Huda W, Garrisi W. Radiation exposure and image quality in chest CT examinations. AJR Am J Roentgenol 2001; 177: 279-84
    CrossrefPubMedGoogle Scholar
  • 19 Worldometers.info, release date November 2020.