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DOI: 10.4103/ijri.IJRI_341_16
Sequential MR imaging (with diffusion-weighted imaging) changes in metronidazole-induced encephalopathy
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Abstract
Metronidazole-induced neuro-toxicity, though rare, is known. A characteristic spatial distribution of lesions in cerebellar dentate nuclei and dorsal pons is known. However, temporal progression of lesions on magnetic resonance imaging (MRI) has not been described previously. We describe two such cases which presented initially with splenial hyperintesity and showed progression to characterstic lesions. Both cases improved with stoppage of metronidazole.
Keywords
Magnetic resonance imaging - metronidazole - metronidazole-induced encephalopathy - splenial hyperintensityPublication History
Article published online:
27 July 2021
© 2017. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Ahmed A, Loes DJ, Bressler EL. Reversible magnetic resonance imaging findings in metronidazole induced encephalopahty. Neurology 1995;45:588-9.
- 2 Kim E, Na DG, Kim EY, Kim JH, Son KR, Chang KH. Imaging of metronidazole induced encephalopathy: Lesion distribution and diffusion-weighted imaging findings. Am J Neuroradiol 2007;28:1652-8.
- 3 Lee SS, Cha SH, Lee SY, Song CJ. Reversible inferior colliculus lesion in metronidazole induced encephalopathy: Magnetic resonance findings on diffusion-weighted and Fluid Attenuated Inversion Recovery Imaging. J Comput Assist Tomogr 2009;33:305-8.
- 4 Kalia V, Vibhuti, Saggar K. Case report: MRI of the brain in metronidazole toxicity. Indian J Radiol Imaging 2010;20:195-7.
- 5 Hardeep M S, Ravindra GK, Mukund VR, Pawan KS. Boomerang sign: Clinical significance of transient lesion in splenium of corpus callosum. Ann Indian Acad Neurol 2012;15:151-7.
- 6 Conti M, Salis A, Urigo C, Canalis L, Frau S, Canalis GC. Transient focal lesion in the splenium of the corpus callosum: MR imaging with an attempt to clinical-physiopathological explanation and review of the literature. Radiol Med 2007;112:921-35.
- 7 Cohen-Gadol AA, Britton JW, Jack CR, Jr, Friedman JA, Marsh WR. Transient postictal magnetic resonance imaging abnormality of the corpus callosum in a patient with epilepsy. Case report and review of the literature. J Neurosurg 2002;97:714-7.
- 8 Oster J, Doherty C, Grant PE, Simon M, Cole AJ. Diffusion-weighted imaging abnormalities in the splenium after seizures. Epilepsia 2003;44:852-4.