Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(02): 169-172
DOI: 10.4103/ijmpo.ijmpo_83_16
Original Article

The Relationship between Serum Selenium and Zinc with Gastroesophageal Cancers in the Southeast of Iran

Seyed Mehdi Hashemi
Department of Hematology and Medical Oncology, Zahedan University of Medical Sciences, Zahedan, Iran
,
Mohamadali Mashhadi
Department of Internal Medicine, Ali-Ebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
,
Alireza Ansari Moghaddam
Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
,
Javad Yousefi
Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
,
Ahmad Dizangian Mofrad
Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
,
Masoud Sadeghi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
,
Abolghasem Allahyari
Department of Hematology and Medical Oncology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
Also available at
  PDF Download Permissions and Reprints

Abstract

Background: Selenium (Se) and zinc (Zn) have antioxidant and anticancer properties. Objective: The aim of this study was to evaluate the serum levels of Se and Zn and the correlation between the levels of these two elements with risk of incidence of esophageal cancer (EC) and gastric cancer (GC). Materials and Methods: In a case–control study, we selected sixty patients with GC or EC as the intervention group and 120 age-matched individuals as the control group. Exclusion criteria were the individuals with kidney and liver failure and the consumer of dietary supplements such as Se and Zn. Measurement of serum Se was done in a graphite furnace system and atomic absorption device of Varian and of serum Zn was done by a flame photometer system (flame) and atomic absorption device of Varian. Results: In thirty patients of ECs, 90% were squamous cell carcinoma and 10% adenocarcinoma, and out of thirty patients of GCs, 90% were intestinal type and 10% diffuse type. The level of two elements in cancer patients was lower than the control group (P < 0.05). There was no significant different between two cancer groups for level of Se and Zn, but there was a significant difference between the control group with two other groups. Conclusion: Our study confirmed the findings from previous prospective studies and randomized trials that reducing of lower levels of Se and Zn can effect on incidence of cancer.

Keywords

Case–control - esophageal cancer - gastric cancer - selenium - zinc


Publication History

Article published online:
06 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
  • 2 Kamangar F, Chow WH, Abnet CC, Dawsey SM. Environmental causes of esophageal cancer. Gastroenterol Clin North Am 2009;38:27-57, vii.
  • 3 Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol 2006;12:354-62.
  • 4 Hosseini Nezhad Z, Darvish Moghaddam S, Zahedi MJ, Hayatbakhsh M, Sharififar F, Ebrahimi Meimand F, et al. Serum selenium level in patients with gastric non-cardia cancer and functional dyspepsia. Iran J Med Sci 2015;40:214-8.
  • 5 Biesalski HK, Grimm P. Pocket Atlas of Nutrition. 3rd ed. Stuttgart: Georg Thieme Verlag; 2005.
  • 6 Ramoutar RR, Brumaghim JL. Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds. Cell Biochem Biophys 2010;58:1-23.
  • 7 Nelson WG, De Marzo AM, Isaacs WB. Prostate cancer. N Engl J Med 2003;349:366-81.
  • 8 Nouarie M, Pourshams A, Kamangar F, Sotoudeh M, Derakhshan MH, Akbari MR, et al. Ecologic study of serum selenium and upper gastrointestinal cancers in Iran. World J Gastroenterol 2004;10:2544-6.
  • 9 Prasad AS, Beck FW, Snell DC, Kucuk O. Zinc in cancer prevention. Nutr Cancer 2009;61:879-87.
  • 10 Abnet CC, Lai B, Qiao YL, Vogt S, Luo XM, Taylor PR, et al. Zinc concentration in esophageal biopsy specimens measured by x-ray fluorescence and esophageal cancer risk. J Natl Cancer Inst 2005;97:301-6.
  • 11 Mashhadi MA, Nezam K, Abdollahinejad MJ. Gastric cancer in South East of Iran. Int J Hematol Oncol Stem Cell Res 2009;3:38-42.
  • 12 Mashhadi MA, Nezam K, Bakhshipour AR, Ttorbati TF, Ansarimoghaddam AR. High prevalence of esophageal cancer in South East of Iran. Int J Hematol Oncol Stem Cell Res 2011;5:18-21.
  • 13 Islami F, Kamangar F, Aghcheli K, Fahimi S, Semnani S, Taghavi N, et al. Epidemiologic features of upper gastrointestinal tract cancers in Northeastern Iran. Br J Cancer 2004;90:1402-6.
  • 14 Rayman MP. Selenium in cancer prevention: A review of the evidence and mechanism of action. Proc Nutr Soc 2005;64:527-42.
  • 15 Lee SR, Bar-Noy S, Kwon J, Levine RL, Stadtman TC, Rhee SG. Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity. Proc Natl Acad Sci U S A 2000;97:2521-6.
  • 16 Koriyama C, Campos FI, Yamamoto M, Serra M, Carrasquilla G, Carrascal E, et al. Toenail selenium levels and gastric cancer risk in Cali, Colombia. J Toxicol Sci 2008;33:227-35.
  • 17 Goyal MM, Kalwar AK, Vyas RK, Bhati A. A study of serum zinc, selenium and copper levels in carcinoma of esophagus patients. Indian J Clin Biochem 2006;21:208-10.
  • 18 Ji JH, Shin DG, Kwon Y, Cho DH, Lee KB, Park SS, et al. Clinical correlation between gastric cancer type and serum selenium and zinc levels. J Gastric Cancer 2012;12:217-22.
  • 19 Rhee JK, Chung JH, Sakong J, Kang PS, Kim CY, Lee KS, et al. Association between cancer and selenium concentration in blood and toenails. Yeungnam Univ J Med 1992;9:29-43.
  • 20 Mark SD, Qiao YL, Dawsey SM, Wu YP, Katki H, Gunter EW, et al. Prospective study of serum selenium levels and incident esophageal and gastric cancers. J Natl Cancer Inst 2000;92:1753-63.
  • 21 Charalabopoulos K, Kotsalos A, Batistatou A, Charalabopoulos A, Peschos D, Vezyraki P, et al. Serum and tissue selenium levels in gastric cancer patients and correlation with CEA. Anticancer Res 2009;29:3465-7.
  • 22 Zhang WH, Wu XJ, Niu JX, Yan H, Wang XZ, Yin XD, et al. Serum zinc status and Helicobacter pylori infection in gastric disease patients. Asian Pac J Cancer Prev 2012;13:5043-6.