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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(01): 103-105
DOI: 10.4103/ijmpo.ijmpo_31_16
Case Report

Multifocal Osseous Epithelioid Hemangioendothelioma Involving Extremities and Spine with Visceral Metastasis

Maitrayee Roy
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Rajni Yadav
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Tarun Kumar
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Epithelioid hemangioendothelioma (EH) is a rare locally aggressive intermediate grade malignant vasoformative tumor. Bone is a rarer primary site accounting for less than 1% of all malignant bone tumors. Multicentricity and/or multifocality are a relatively frequent occurrence, most commonly clustered in the bones of lower extremities. The axial skeleton is less commonly affected, and concomitant visceral involvement is rarer. We report a unique case of a 20-year-old male who presented with multiple lytic lesions in the skull vault, vertebral bones, bilateral proximal femur, and both radii and humerii with metastasis to the lungs and liver. A final diagnosis of EH was established on biopsy from the right iliac bone. He initially received multiagent chemotherapy and is currently on antiangiogenic therapy. On follow-up positron emission tomography–computerized tomography done 6 months later, marked reduction in fluoro-D-glucose avidity of the hepatic and most skeletal lesions was noted.

Keywords

Bone - epithelioid hemangioendothelioma - lower extremities - metastasis - spine


Publication History

Article published online:
23 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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