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DOI: 10.4103/ijmpo.ijmpo_276_19
Interim-Response-Adapted Therapy in Advanced Hodgkin’s Lymphoma: Current Status
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It has been 6 years after our initial publication of a phase II trial of response-adapted therapy (RAT) in advanced Hodgkin’s lymphoma (aHL), which was one of the first prospective studies published using RAT in aHL.[1] We had treated patients with aHL (defined as Stage IIB, III, and IV) with two cycles of ABVD and then performed an interim positron emission tomography/computed tomography (iPET-CT) scan iPET2. Those who had a Deauville score (DS) of 4 or 5 received four cycles of escalated BEACOPP (EB) and those with DS 1–3 continued 4 more ABVD. The disease-free survival (DFS) at 2 years was 76%, and overall survival (OS) was 88%. With more mature follow-up, the DFS at 5 years was 77%, and OS was 85% for the entire cohort of 50 patients.[2] The survival was inferior among iPET2+ (5-year DFS [50%] and OS [62%]) versus iPET2-−ve patients (5-year DFS [82%] and OS [85%]). These results have been replicated in much larger multicenter studies globally, and RAT has been accepted as one of the standard modes of treatment in aHL.
Publication History
Received: 28 December 2019
Accepted: 06 January 2020
Article published online:
03 June 2021
© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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