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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(06): 920-922
DOI: 10.4103/ijmpo.ijmpo_267_20
Case Report with Review of Literature

Diagnosing Primary Malignancy in Leptomeningeal Carcinomatosis by Using CSF Cytology and Immunohistochemistry: A Case Report

Navaneeth Reddy Hasthavaram
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
,
Tina Dadu
Department of Pathology, Dr BLK Hospital, New Delhi, India
,
Rajan Duggal
Department of Pathology, Dr BLK Hospital, New Delhi, India
,
Suhail Qureshi
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
,
Saphalta Baghmar
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
,
Amit Agarwal
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
,
Aseem Khurana
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
,
Aditya Sarin
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
,
Navdeep Singh
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
,
Ramesh Kumar
Department of Medical Oncology, Dr BLK Hospital, New Delhi, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

We present a rare case of recurrent carcinoma of gallbladder with leptomeningeal carcinomatosis. Cerebrospinal fluid (CSF) cytology showed atypical cells, which were suspicious for malignancy on initial reporting. Diagnosis of malignancy and primary from hepatobiliary source was confirmed by doing immunohistochemistry on CSF cell block.

Keywords

Gallbladder carcinoma - immunohistochemistry - leptomeningeal


Publication History

Received: 30 May 2020

Accepted: 23 August 2020

Article published online:
14 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Wistuba II, Gazdar AF. Gallbladder cancer: Lessons from a rare tumour. Nat Rev Cancer 2004; 4: 695-706
    CrossrefPubMedSearch in Google Scholar
  • 2 Mhatre SS, Nagrani RT, Budukh A, Chiplunkar S, Badwe R, Patil P. et al. Place of birth and risk of gallbladder cancer in India. Indian J Cancer 2016; 53: 304-8
    CrossrefPubMedSearch in Google Scholar
  • 3 Lobo L, Prasad K, Satoskar RR. Carcinoma of the gall bladder. J Clin Diagn Res 2012; 6: 692-5
    Search in Google Scholar
  • 4 Sons HU, Borchard F, Joel BS. Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature. J Surg Oncol 1985; 28: 199-206
    CrossrefPubMedSearch in Google Scholar
  • 5 Naylor AR, MacGregor JE, Hutcheon AW, Best PV. Meningeal carcinomatosis from a clinically undiagnosed signet ring cell primary in the gall bladder. Surg Neurol 1988; 29: 315-8
    CrossrefPubMedSearch in Google Scholar
  • 6 Miyagui T, Luchemback L, Teixeira GH, de Azevedo KM. Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor. Rev Hosp Clin Fac Med Sao Paulo 2003; 58: 169-72
    CrossrefPubMedSearch in Google Scholar
  • 7 Hovestadt A, Henzen-Logmans SC, Vecht CJ. Immunohistochemical analysis of the cerebrospinal fluid for carcinomatous and lymphomatous leptomeningitis. Br J Cancer 1990; 62: 653-4
    CrossrefPubMedSearch in Google Scholar
  • 8 Gleissner B, Chamberlain MC. Neoplastic meningitis. Lancet Neurol 2006; 5: 443-52
    CrossrefPubMedSearch in Google Scholar
  • 9 Mack F, Baumert BG, Schäfer N, Hattingen E, Scheffler B, Herrlinger U. et al. Therapy of leptomeningeal metastasis in solid tumors. Cancer Treat Rev 2016; 43: 83-91
    CrossrefPubMedSearch in Google Scholar
  • 10 Grossman SA, Krabak MJ. “Leptomeningeal carcinomatosis. ” Cancer Treat Rev 1999; 25: 103-19
    CrossrefPubMedSearch in Google Scholar
  • 11 Kawamata T, Kawamura H, Kubo O, Sasahara A, Yamazato M, Hori T, Sarin YK. “Central nervous system metastasis from gallbladder carcinoma mimicking a meningioma. Case illustration.”. J Neurosur 1999; 91: 1059
    CrossrefPubMedSearch in Google Scholar
  • 12 Takano S, Yoshii Y, Owada T, Shirai S, Nose T. et al. ”Central nervous system metastasis from gallbladder carcinoma. Case report.”. Neurologia Medico-Chirurgica 1991; 31: 782-6
    CrossrefPubMedSearch in Google Scholar
  • 13 Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: Geographical distribution and risk factors. Int J Cancer 2006; 118: 1591-602
    CrossrefPubMedSearch in Google Scholar