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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(03): 440-444
DOI: 10.4103/ijmpo.ijmpo_246_17
Case Report

Metaplastic Carcinoma of Breast: Case Series with Cytohistological Correlation

Neelam Sood
Department of Pathology and Lab Medicine, Deen Dayal Upadhyay Hospital, Government of NCT, Hari Nagar, New Delhi, India
,
Sanjay Gupta
Division of Cytopathology, National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India
,
Soin Navmeet
Department of Pathology, Deen Dayal Upadhyay Hospital, New Delhi, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Metaplastic carcinoma of breast (MCB) is a rare breast malignancy. It is important to differentiate metaplastic carcinoma from malignant phyllodes and primary breast sarcomas because of their differing biological behavior and prognosis. We report four cases of MCB diagnosed over the past 15 years. Retrospective review of patient records in a tertiary care setting to retrieve cases diagnosed as MCB. Patient records of the past 15 years (2002–2015) were retrieved. Four histopathologically diagnosed cases of metaplastic carcinoma out of a total of 880 archived cases of breast carcinoma were studied along with their cytopathology. Immunohistochemistry was performed on sections. MCB comprised 0.45% of all breast malignancies. The four cases of MCB included MCB with chondroid metaplasia, spindle cell carcinoma, adenosquamous carcinoma, and carcinosarcoma. All the tumors were invariably triple negative (estrogen receptor, progesterone receptor, and Her2/Neu negative) and expression of other epithelial and mesenchymal markers was variable. MCB is a rare breast malignancy. Differential diagnosis is related to the presence of heterologous elements and degree of atypia seen in the lesion. It is important to be aware of this entity as it carries a poor prognosis.

Keywords

Breast - carcinoma - fine-needle aspiration cytology - histopathology - immunohistochemistry - metaplastic


Publication History

Received: 12 December 2017

Accepted: 19 April 2019

Article published online:
03 June 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Huvos AG, Lucas Jr. JC, Foote Jr. FW. Metaplastic breast carcinoma. Rare form of mammary cancer. N Y State J Med 1973; 73: 1078-82
    PubMedGoogle Scholar
  • 2 Ellis IO, Schnitt SJ, Sastre-Garau X, Bussolati G, Tavassoli FA, Eusebi V. et al. Invasive breast carcinoma. In Tavassoli FA, Devilee P. editors WHO Classification of Tumors of the Breast. Lyon, France: IARC; 2003: 37-40
    Google Scholar
  • 3 Tavassoli FA. Classification of metaplastic carcinomas of the breast. Pathol Annu 1992; 27 Pt 2 89-119
    PubMedGoogle Scholar
  • 4 Al Sayed AD, El Weshi AN, Tulbah AM, Rahal MM, Ezzat AA. Metaplastic carcinoma of the breast clinical presentation, treatment results and prognostic factors. Acta Oncol 2006; 45: 188-95
    CrossrefPubMedGoogle Scholar
  • 5 Rossi L, Paglicci C, Caprio G, Barberi S, Ranieri E, Zancla S. et al. Matrix-producing carcinoma of the breast: A case report. Case Rep Oncol 2013; 6: 245-9
    CrossrefPubMedGoogle Scholar
  • 6 Rungta S, Kleer CG. Metaplastic carcinomas of the breast: Diagnostic challenges and new translational insights. Arch Pathol Lab Med 2012; 136: 896-900
    CrossrefPubMedGoogle Scholar
  • 7 Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast: V. Metaplastic carcinoma with osteoclastic giant cells. Hum Pathol 1990; 21: 1142-50
    PubMedGoogle Scholar
  • 8 Graziano L, Filho GP, Bitencourt AG, Soto DB, Hiro A, Nunes CC. et al. Metaplastic squamous cell carcinoma of the breast: A case report and literature review. Rev Assoc Med Bras (1992) 2016; 62: 618-21
    CrossrefPubMedGoogle Scholar
  • 9 Joshi D, Singh P, Zonunfawni Y, Gangane N. Metaplastic carcinoma of the breast: Cytological diagnosis and diagnostic pitfalls. Acta Cytol 2011; 55: 313-8
    CrossrefPubMedGoogle Scholar
  • 10 Papazian M, Kalantzis I, Galanopoulos G, Mani I, Tzaida O, Iacovidou I. et al. Malignant myoepithelioma of the breast: A case report and review of the literature. Mol Clin Oncol 2016; 4: 723-7
    CrossrefPubMedGoogle Scholar
  • 11 Niu Y, Liao X, Li X, Zhao L. Breast carcinoma with osteoclastic giant cells: Case report and review of the literature. Int J Clin Exp Pathol 2014; 7: 1788-91
    PubMedGoogle Scholar
  • 12 Neelam S, Sanjay G. Invasive duct carcinoma of the breast with multinucleated osteoclast-like giant cells: A rare case diagnosed on fine needle aspiration cytology. Breast J 2012; 18: 596-7
    CrossrefPubMedGoogle Scholar
  • 13 Adem C, Reynolds C, Ingle JN, Nascimento AG. Primary breast sarcoma: Clinicopathologic series from the mayo clinic and review of the literature. Br J Cancer 2004; 91: 237-41
    CrossrefPubMedGoogle Scholar
  • 14 Tse GM, Tan PH, Putti TC, Lui PC, Chaiwun B, Law BK. et al. Metaplastic carcinoma of the breast: A clinicopathological review. J Clin Pathol 2006; 59: 1079-83
    CrossrefPubMedGoogle Scholar
  • 15 Altaf FJ, Mokhtar GA, Emam E, Bokhary RY, Mahfouz NB, Al Amoudi S. et al. Metaplastic carcinoma of the breast: An immunohistochemical study. Diagn Pathol 2014; 9: 139
    CrossrefPubMedGoogle Scholar