CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(02): 165-171
DOI: 10.4103/ijmpo.ijmpo_161_19
Editorial

Peptide Receptor Radionuclide Therapy in the Management of Neuroendocrine Tumors (Neoplasms)[*]: Fundamentals and Salient Clinical Practice Points for Medical Oncologists

Sandip Basu
Radiation Medicine Centre Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra
Homi Bhabha National Institute, DAE’s University, Mumbai, Maharashtra
,
Rahul Parghane
Radiation Medicine Centre Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra
Homi Bhabha National Institute, DAE’s University, Mumbai, Maharashtra
,
Rohit Ranade
Radiation Medicine Centre Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra
Homi Bhabha National Institute, DAE’s University, Mumbai, Maharashtra
,
Pradeep Thapa
Radiation Medicine Centre Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra
Homi Bhabha National Institute, DAE’s University, Mumbai, Maharashtra
,
Anant Ramaswamy
Homi Bhabha National Institute, DAE’s University, Mumbai, Maharashtra
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
,
Vikas Ostwal
Homi Bhabha National Institute, DAE’s University, Mumbai, Maharashtra
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
,
Bhawna Sirohi
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Department of Medical Oncology, Max Institute of Cancer Care, New Delhi, India
,
Dipanjan Panda
Department of Medical Oncology, Indraprastha Apollo Hospital, New Delhi, India
,
Shailesh V Shrikhande
Department of Surgical Oncology, Gastrointestinal and Hepato-Pancreato-Biliary Service, Tata Memorial Hospital, Mumbai, Maharashtra
› Author Affiliations
Financial support and sponsorship Nil.
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Abstract

This editorial commentary is an expert summary of “Peptide Receptor Radionuclide Therapy (PRRT),” encompassing the essential fundamentals and salient clinical practice points, deliberated and designed in a point-wise manner with theme-based subheadings. Emphasis has been laid on the topics of practical relevance to the referring oncologists with relevant finer points where necessary. A part of the presented overview has been generated from the authors' own practical experience of more than 3500 successful therapies delivered over the last 9 years at a large tertiary care PRRT setting by the joint efforts of Radiation Medicine Centre (RMC), Bhabha Atomic Research Centre (BARC), and Gastrointestinal services of Tata Memorial Hospital (TMH) at the TMH-RMC premises. While the technical indigenization is beyond the scope of this treatise, we must mention here that India had been one of the frontrunners in this treatment modality, and the PRRT services in this country were developed purely as an indigenous effort right from the production of the radionuclide (177-Lutetium) at the reactor and radiolabeling and production of the radiopharmaceutical (177Lu-DOTATATE) by the radiopharmaceutical scientists at the BARC and RMC; such an endeavor allowed this very specialized therapy to be delivered at a very affordable cost in our setting which could be viewed as a major societal contribution of the atomic energy research in this country.

* * As per the International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus recommendations in 2017, the authors would use the term “Neoplasms” rather than “Tumors” throughout the document.[1]




Publication History

Article published online:
03 June 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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